FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019647562> ?p ?o ?g. }

• W2019647562 endingPage "821" @default.
• W2019647562 startingPage "803" @default.
• W2019647562 abstract "Abstract In eukaryotic cells, phosphatidylserine (PS) is predominantly located in the cytosolic leaflet of the plasma membrane; this asymmetry is generated by an unknown mechanism. In this study, we used the PS‐specific probe mRFP ‐Lact‐C2 to investigate the possible involvement of type 4 P‐type ATPases, also called phospholipid flippases, in the generation of this asymmetry in Saccharomyces cerevisiae . PS was not found in the trans ‐Golgi Network in wild‐type cells, but it became exposed when vesicle formation was compromised in the sec7 mutant, and it was also exposed on secretory vesicles (SVs), as reported previously. However, flippase mutations did not reduce the exposure of PS in either case, even at low levels that would only be detectable by quantitative analysis of mRFP ‐Lact‐C2 fluorescence in isolated SVs. Furthermore, no reduction in the PS level was observed in a mutant with multiple flippase mutations. Because PS was not exposed in a mutant that accumulates ER or cis /medial‐Golgi membranes, Golgi maturation seems to be a prerequisite for PS translocation. Our results suggest that an unknown mechanism, possibly a protein with flippase‐like activity, acts in conjunction with known flippases to regulate PS translocation." @default.
• W2019647562 created "2016-06-24" @default.
• W2019647562 creator A5019046629 @default.
• W2019647562 creator A5051875550 @default.
• W2019647562 creator A5065435169 @default.
• W2019647562 date "2014-09-13" @default.
• W2019647562 modified "2023-10-07" @default.
• W2019647562 title "Asymmetric distribution of phosphatidylserine is generated in the absence of phospholipid flippases in<i>Saccharomyces cerevisiae</i>" @default.
• W2019647562 cites W126794640 @default.
• W2019647562 cites W1483456869 @default.
• W2019647562 cites W1501088201 @default.
• W2019647562 cites W1515820929 @default.
• W2019647562 cites W1965688791 @default.
• W2019647562 cites W1966072209 @default.
• W2019647562 cites W1971859508 @default.
• W2019647562 cites W1975080081 @default.
• W2019647562 cites W1976264442 @default.
• W2019647562 cites W1989126866 @default.
• W2019647562 cites W2002292732 @default.
• W2019647562 cites W2003709444 @default.
• W2019647562 cites W2009863454 @default.
• W2019647562 cites W2012810176 @default.
• W2019647562 cites W2013541506 @default.
• W2019647562 cites W2015588017 @default.
• W2019647562 cites W2022598996 @default.
• W2019647562 cites W2025234694 @default.
• W2019647562 cites W2025260671 @default.
• W2019647562 cites W2030015485 @default.
• W2019647562 cites W2046138985 @default.
• W2019647562 cites W2046189032 @default.
• W2019647562 cites W2048735103 @default.
• W2019647562 cites W2049004271 @default.
• W2019647562 cites W2054697729 @default.
• W2019647562 cites W2055055808 @default.
• W2019647562 cites W2055321959 @default.
• W2019647562 cites W2059775037 @default.
• W2019647562 cites W2061539000 @default.
• W2019647562 cites W2081126382 @default.
• W2019647562 cites W2086449873 @default.
• W2019647562 cites W2087031102 @default.
• W2019647562 cites W2089860059 @default.
• W2019647562 cites W2100138389 @default.
• W2019647562 cites W2101441813 @default.
• W2019647562 cites W2105782873 @default.
• W2019647562 cites W2114519069 @default.
• W2019647562 cites W2115245133 @default.
• W2019647562 cites W2116970732 @default.
• W2019647562 cites W2117655042 @default.
• W2019647562 cites W2119905730 @default.
• W2019647562 cites W2124650255 @default.
• W2019647562 cites W2130255848 @default.
• W2019647562 cites W2134104591 @default.
• W2019647562 cites W2135465645 @default.
• W2019647562 cites W2135585405 @default.
• W2019647562 cites W2137943169 @default.
• W2019647562 cites W2138952800 @default.
• W2019647562 cites W2141612710 @default.
• W2019647562 cites W2145530482 @default.
• W2019647562 cites W2148231248 @default.
• W2019647562 cites W2152567230 @default.
• W2019647562 cites W2153405295 @default.
• W2019647562 cites W2155955312 @default.
• W2019647562 cites W2157513547 @default.
• W2019647562 cites W2159516959 @default.
• W2019647562 cites W2161438543 @default.
• W2019647562 cites W2166840071 @default.
• W2019647562 cites W2168159711 @default.
• W2019647562 cites W2170280114 @default.
• W2019647562 cites W2300552860 @default.
• W2019647562 cites W2344804693 @default.
• W2019647562 cites W4255794096 @default.
• W2019647562 doi "https://doi.org/10.1002/mbo3.211" @default.
• W2019647562 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4234269" @default.
• W2019647562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25220349" @default.
• W2019647562 hasPublicationYear "2014" @default.
• W2019647562 type Work @default.
• W2019647562 sameAs 2019647562 @default.
• W2019647562 citedByCount "14" @default.
• W2019647562 countsByYear W20196475622015 @default.
• W2019647562 countsByYear W20196475622016 @default.
• W2019647562 countsByYear W20196475622017 @default.
• W2019647562 countsByYear W20196475622018 @default.
• W2019647562 countsByYear W20196475622019 @default.
• W2019647562 countsByYear W20196475622020 @default.
• W2019647562 countsByYear W20196475622021 @default.
• W2019647562 crossrefType "journal-article" @default.
• W2019647562 hasAuthorship W2019647562A5019046629 @default.
• W2019647562 hasAuthorship W2019647562A5051875550 @default.
• W2019647562 hasAuthorship W2019647562A5065435169 @default.
• W2019647562 hasBestOaLocation W20196475622 @default.
• W2019647562 hasConcept C104317684 @default.
• W2019647562 hasConcept C119062480 @default.
• W2019647562 hasConcept C12554922 @default.
• W2019647562 hasConcept C130316041 @default.
• W2019647562 hasConcept C143065580 @default.
• W2019647562 hasConcept C158617107 @default.
• W2019647562 hasConcept C185592680 @default.
• W2019647562 hasConcept C188810444 @default.

• next