Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019651009> ?p ?o ?g. }
- W2019651009 endingPage "58" @default.
- W2019651009 startingPage "54" @default.
- W2019651009 abstract "Heart failure is the most common cause of mortality in β-thalassaemia major. However, the management of this disease, apart from chelation therapy, is largely empirical. Therefore, we decided to evaluate the effect of metoprolol succinate on patients with thalassaemia cardiomyopathy (TCM).In this clinical trial, 45 patients with TCM were randomised to receive either metoprolol (n=26) or placebo (n=19). Echocardiography and a 6 min walk test were performed at baseline and repeated after 6 months and the values compared.In the metoprolol group, left ventricular ejection fraction (LVEF) rose from 38.65% to 42.84% (p<0.001), while it decreased in the placebo group from 37.89% to 35.84% (p=0.01); the difference between the two groups was significant (p<0.001). Left ventricular (LV) mass in the metoprolol group decreased from 154.31 to 144.26 g (p=0.02), while in the placebo group it increased from 174.32 to 200.15 g (p=0.68); the difference between the two groups was significant (p<0.001). End systolic volume (ESV) decreased in the metoprolol group from 42.19 to 36.73 cm(3) (p<0.001) but increased from 47.37 to 57.42 cm(3) in the placebo group (p=0.144); the difference between the groups was significant (p<0.001). No differences in exercise capacity or pulmonary capillary wedge pressure were seen between the two groups (p=0.268 and p=0.535, respectively).Metoprolol succinate as a β-blocker may have the potential to significantly improve systolic function in patients with TCM and reverse LV remodelling to the same extent as in other types of cardiomyopathy.NCT01863173." @default.
- W2019651009 created "2016-06-24" @default.
- W2019651009 creator A5032331674 @default.
- W2019651009 creator A5042283668 @default.
- W2019651009 creator A5066938582 @default.
- W2019651009 creator A5076683606 @default.
- W2019651009 creator A5087884270 @default.
- W2019651009 date "2014-04-17" @default.
- W2019651009 modified "2023-10-14" @default.
- W2019651009 title "The effect of metoprolol succinate on the cardiac function of patients with thalassaemia cardiomyopathy: a double-blind randomised study" @default.
- W2019651009 cites W1513300725 @default.
- W2019651009 cites W1548375036 @default.
- W2019651009 cites W1551617732 @default.
- W2019651009 cites W1602804702 @default.
- W2019651009 cites W1979973214 @default.
- W2019651009 cites W1983640769 @default.
- W2019651009 cites W1985491842 @default.
- W2019651009 cites W2000650260 @default.
- W2019651009 cites W2001173102 @default.
- W2019651009 cites W2009557907 @default.
- W2019651009 cites W2013110668 @default.
- W2019651009 cites W2018278587 @default.
- W2019651009 cites W2023372983 @default.
- W2019651009 cites W2023606650 @default.
- W2019651009 cites W2025189399 @default.
- W2019651009 cites W2031158961 @default.
- W2019651009 cites W2043054489 @default.
- W2019651009 cites W2052240301 @default.
- W2019651009 cites W2077380630 @default.
- W2019651009 cites W2082283198 @default.
- W2019651009 cites W2083867296 @default.
- W2019651009 cites W2109712401 @default.
- W2019651009 cites W2120271642 @default.
- W2019651009 cites W2121448254 @default.
- W2019651009 cites W2122984949 @default.
- W2019651009 cites W2128195071 @default.
- W2019651009 cites W2153506007 @default.
- W2019651009 cites W2155366163 @default.
- W2019651009 cites W2159216142 @default.
- W2019651009 cites W2186805710 @default.
- W2019651009 cites W2412781077 @default.
- W2019651009 cites W2547764458 @default.
- W2019651009 cites W2614343168 @default.
- W2019651009 cites W3187992181 @default.
- W2019651009 cites W4246277767 @default.
- W2019651009 cites W53968479 @default.
- W2019651009 doi "https://doi.org/10.1136/heartasia-2013-010460" @default.
- W2019651009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4832708" @default.
- W2019651009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27326168" @default.
- W2019651009 hasPublicationYear "2014" @default.
- W2019651009 type Work @default.
- W2019651009 sameAs 2019651009 @default.
- W2019651009 citedByCount "3" @default.
- W2019651009 countsByYear W20196510092016 @default.
- W2019651009 countsByYear W20196510092020 @default.
- W2019651009 countsByYear W20196510092021 @default.
- W2019651009 crossrefType "journal-article" @default.
- W2019651009 hasAuthorship W2019651009A5032331674 @default.
- W2019651009 hasAuthorship W2019651009A5042283668 @default.
- W2019651009 hasAuthorship W2019651009A5066938582 @default.
- W2019651009 hasAuthorship W2019651009A5076683606 @default.
- W2019651009 hasAuthorship W2019651009A5087884270 @default.
- W2019651009 hasBestOaLocation W20196510091 @default.
- W2019651009 hasConcept C111566952 @default.
- W2019651009 hasConcept C126322002 @default.
- W2019651009 hasConcept C142724271 @default.
- W2019651009 hasConcept C164705383 @default.
- W2019651009 hasConcept C204787440 @default.
- W2019651009 hasConcept C27081682 @default.
- W2019651009 hasConcept C2778198053 @default.
- W2019651009 hasConcept C2778797674 @default.
- W2019651009 hasConcept C2781280847 @default.
- W2019651009 hasConcept C71924100 @default.
- W2019651009 hasConcept C78085059 @default.
- W2019651009 hasConceptScore W2019651009C111566952 @default.
- W2019651009 hasConceptScore W2019651009C126322002 @default.
- W2019651009 hasConceptScore W2019651009C142724271 @default.
- W2019651009 hasConceptScore W2019651009C164705383 @default.
- W2019651009 hasConceptScore W2019651009C204787440 @default.
- W2019651009 hasConceptScore W2019651009C27081682 @default.
- W2019651009 hasConceptScore W2019651009C2778198053 @default.
- W2019651009 hasConceptScore W2019651009C2778797674 @default.
- W2019651009 hasConceptScore W2019651009C2781280847 @default.
- W2019651009 hasConceptScore W2019651009C71924100 @default.
- W2019651009 hasConceptScore W2019651009C78085059 @default.
- W2019651009 hasIssue "1" @default.
- W2019651009 hasLocation W20196510091 @default.
- W2019651009 hasLocation W20196510092 @default.
- W2019651009 hasLocation W20196510093 @default.
- W2019651009 hasLocation W20196510094 @default.
- W2019651009 hasOpenAccess W2019651009 @default.
- W2019651009 hasPrimaryLocation W20196510091 @default.
- W2019651009 hasRelatedWork W1548375036 @default.
- W2019651009 hasRelatedWork W2167036398 @default.
- W2019651009 hasRelatedWork W2351059507 @default.
- W2019651009 hasRelatedWork W2363366439 @default.
- W2019651009 hasRelatedWork W2364230676 @default.
- W2019651009 hasRelatedWork W2380680365 @default.