FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019653755> ?p ?o ?g. }

• W2019653755 endingPage "111" @default.
• W2019653755 startingPage "106" @default.
• W2019653755 abstract "Phospholipase Cε (PLCε) is a unique class of PLC regulated by both Ras family small GTPases and heterotrimeric G proteins. We previously showed by using mice bearing its null or transgenic allele that PLCε plays a crucial role in various forms of skin inflammation through upregulation of proinflammatory cytokine production from keratinocytes. However, molecular mechanisms how PLCε augments cytokine production were largely unknown. We show here using cultured human keratinocyte PHK16-0b cells that induction of the expression of chemokine (C-C motif) ligand 2 (CCL2) following stimulation with tumor necrosis factor (TNF)α, which primarily depends on the activation of the NF-κB pathway, is abrogated by small interfering RNA-mediated knockdown of PLCε. Enforced expression of PLCε causes substantial CCL2 expression and cooperates with low level TNFα stimulation to induce marked overexpression of CCL2, both of which are only partially blocked by pharmacological inhibition of the NF-κB signaling. However, PLCε knockdown exhibits no effect on both the NF-κB-cis-element-mediated transcription per se and the post-translational modifications of NF-κB implicated in transcriptional regulation, suggesting that PLCε constitutes a yet unknown signaling pathway distinct from the NF-κB pathway. This pathway can cooperate with the NF-κB pathway to achieve a synergistic TNFα-stimulated CCL2 induction in keratinocytes." @default.
• W2019653755 created "2016-06-24" @default.
• W2019653755 creator A5029408141 @default.
• W2019653755 creator A5054301688 @default.
• W2019653755 creator A5060617351 @default.
• W2019653755 date "2011-10-01" @default.
• W2019653755 modified "2023-10-18" @default.
• W2019653755 title "PLCε cooperates with the NF-κB pathway to augment TNFα-stimulated CCL2/MCP1 expression in human keratinocyte" @default.
• W2019653755 cites W1575383081 @default.
• W2019653755 cites W1598297922 @default.
• W2019653755 cites W1822745879 @default.
• W2019653755 cites W2001916228 @default.
• W2019653755 cites W2018011543 @default.
• W2019653755 cites W2019342271 @default.
• W2019653755 cites W2038725731 @default.
• W2019653755 cites W2046208657 @default.
• W2019653755 cites W2052489712 @default.
• W2019653755 cites W2055211034 @default.
• W2019653755 cites W2055725649 @default.
• W2019653755 cites W2066954006 @default.
• W2019653755 cites W2073535369 @default.
• W2019653755 cites W2073816668 @default.
• W2019653755 cites W2074740965 @default.
• W2019653755 cites W2095013915 @default.
• W2019653755 cites W2104688235 @default.
• W2019653755 cites W2116903886 @default.
• W2019653755 cites W2150589615 @default.
• W2019653755 cites W2155849087 @default.
• W2019653755 cites W2161579926 @default.
• W2019653755 cites W2164499356 @default.
• W2019653755 cites W2168959650 @default.
• W2019653755 cites W2170909470 @default.
• W2019653755 doi "https://doi.org/10.1016/j.bbrc.2011.09.032" @default.
• W2019653755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21951843" @default.
• W2019653755 hasPublicationYear "2011" @default.
• W2019653755 type Work @default.
• W2019653755 sameAs 2019653755 @default.
• W2019653755 citedByCount "19" @default.
• W2019653755 countsByYear W20196537552012 @default.
• W2019653755 countsByYear W20196537552013 @default.
• W2019653755 countsByYear W20196537552014 @default.
• W2019653755 countsByYear W20196537552015 @default.
• W2019653755 countsByYear W20196537552016 @default.
• W2019653755 countsByYear W20196537552017 @default.
• W2019653755 countsByYear W20196537552019 @default.
• W2019653755 countsByYear W20196537552021 @default.
• W2019653755 countsByYear W20196537552022 @default.
• W2019653755 crossrefType "journal-article" @default.
• W2019653755 hasAuthorship W2019653755A5029408141 @default.
• W2019653755 hasAuthorship W2019653755A5054301688 @default.
• W2019653755 hasAuthorship W2019653755A5060617351 @default.
• W2019653755 hasConcept C104317684 @default.
• W2019653755 hasConcept C127561419 @default.
• W2019653755 hasConcept C13373296 @default.
• W2019653755 hasConcept C164027704 @default.
• W2019653755 hasConcept C173396325 @default.
• W2019653755 hasConcept C17991360 @default.
• W2019653755 hasConcept C190283241 @default.
• W2019653755 hasConcept C203014093 @default.
• W2019653755 hasConcept C22615655 @default.
• W2019653755 hasConcept C2776914184 @default.
• W2019653755 hasConcept C2777730290 @default.
• W2019653755 hasConcept C54009773 @default.
• W2019653755 hasConcept C54355233 @default.
• W2019653755 hasConcept C55493867 @default.
• W2019653755 hasConcept C62478195 @default.
• W2019653755 hasConcept C81885089 @default.
• W2019653755 hasConcept C86803240 @default.
• W2019653755 hasConcept C95444343 @default.
• W2019653755 hasConceptScore W2019653755C104317684 @default.
• W2019653755 hasConceptScore W2019653755C127561419 @default.
• W2019653755 hasConceptScore W2019653755C13373296 @default.
• W2019653755 hasConceptScore W2019653755C164027704 @default.
• W2019653755 hasConceptScore W2019653755C173396325 @default.
• W2019653755 hasConceptScore W2019653755C17991360 @default.
• W2019653755 hasConceptScore W2019653755C190283241 @default.
• W2019653755 hasConceptScore W2019653755C203014093 @default.
• W2019653755 hasConceptScore W2019653755C22615655 @default.
• W2019653755 hasConceptScore W2019653755C2776914184 @default.
• W2019653755 hasConceptScore W2019653755C2777730290 @default.
• W2019653755 hasConceptScore W2019653755C54009773 @default.
• W2019653755 hasConceptScore W2019653755C54355233 @default.
• W2019653755 hasConceptScore W2019653755C55493867 @default.
• W2019653755 hasConceptScore W2019653755C62478195 @default.
• W2019653755 hasConceptScore W2019653755C81885089 @default.
• W2019653755 hasConceptScore W2019653755C86803240 @default.
• W2019653755 hasConceptScore W2019653755C95444343 @default.
• W2019653755 hasFunder F4320320912 @default.
• W2019653755 hasIssue "1" @default.
• W2019653755 hasLocation W20196537551 @default.
• W2019653755 hasLocation W20196537552 @default.
• W2019653755 hasOpenAccess W2019653755 @default.
• W2019653755 hasPrimaryLocation W20196537551 @default.
• W2019653755 hasRelatedWork W1563693098 @default.
• W2019653755 hasRelatedWork W1987600894 @default.
• W2019653755 hasRelatedWork W2043283213 @default.
• W2019653755 hasRelatedWork W2071810716 @default.
• W2019653755 hasRelatedWork W2136400813 @default.

• next