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• W2019655306 abstract "Context Fluid methylated DNA may be a suitable biomarker for cancer patients. Objective To investigate whether circulating methylated tissue inhibitor of metalloproteinase 3 (TIMP-3) DNA in body fluids is a useful prognostic biomarker in gastric cancer (GC). Design TIMP-3 methylation was detected by real-time methylation-specific polymerase chain reaction in tumor tissues, paired preoperative peritoneal washes (PPWs), and paired serum samples from 92 GC patients. Results The frequency of TIMP-3 methylation was significantly elevated in GC tissues (63.04%; 58 of 92) compared with that in paired adjacent normal tissue (4.3%; 4 of 92) (P &lt; .001). TIMP-3 methylation correlated closely with peritoneal metastasis and TNM stage (all P &lt; .001). The frequency of TIMP-3 methylation in preoperative peritoneal washes and serum samples was 53.3% (49 of 92) and 58.7% (54 of 92), respectively. The Aζ values of the receiver operator characteristic curve for methylated TIMP-3 were 0.966 and 0.922 for serum and preoperative peritoneal washes, respectively, compared with those in GC tissues. The patients with elevated methylated TIMP-3 levels in body fluids had poorer disease-free survival rates than those without (all P &lt; .001). Cox regression analysis showed that detection of methylated TIMP-3 DNA in body fluids was an independent risk factor for GC patients, with a remarkable decrease in disease-free survival 30 months after surgical resection of the gastric tumor. Conclusion Presence of methylated TIMP-3 DNA in body fluids is a useful biomarker for predicting the progression and prognosis of GC patients." @default.
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• W2019655306 date "2014-11-01" @default.
• W2019655306 modified "2023-09-25" @default.
• W2019655306 title "Methylated TIMP-3 DNA in Body Fluids Is an Independent Prognostic Factor for Gastric Cancer" @default.
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• W2019655306 doi "https://doi.org/10.5858/arpa.2013-0285-oa" @default.
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