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- W2019656556 abstract "Common architecture of cytokine receptors and G-protein coupled receptors (GPCRs) may underlie pathological receptor heteromer formation and signaling. Here, we clarify how chemokines and cytokines can participate in pathogenic processes of Parkinson's disease, especially in dopaminergic neurons of substantia nigra. Possible common architecture of GPCRs and cytokine receptors suggests that they may act as molecular switches similar to the prototypical innate immune receptors: Toll-like receptors. Thus, pathological signaling (as well as trafficking and internalization) of receptors may be initiated by their incorrect dimerization depending on direct or indirect (via adaptor proteins) receptor-receptor interactions, leading to neuroinflammatory responses." @default.
- W2019656556 created "2016-06-24" @default.
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- W2019656556 date "2008-08-01" @default.
- W2019656556 modified "2023-10-02" @default.
- W2019656556 title "A new road to neuroinflammation in Parkinson's disease?" @default.
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- W2019656556 doi "https://doi.org/10.1016/j.brainresrev.2008.04.003" @default.
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