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- W2019663496 abstract "Here we describe features of the first non-mammalian T-type calcium channel (LCa(v)3) expressed in vitro. This molluscan channel possesses combined biophysical properties that are reminiscent of all mammalian T-type channels. It exhibits T-type features such as transient kinetics, but the tiny label, usually associated with Ba(2+) conductance, is hard to reconcile with the bigness of this channel in many respects. LCa(v)3 is 25% larger than any voltage-gated ion channel expressed to date. It codes for a massive, 322-kDa protein that conducts large macroscopic currents in vitro. LCa(v)3 is also the most abundant Ca(2+) channel transcript in the snail nervous system. A window current at typical resting potentials appears to be at least as large as that reported for mammalian channels. This distant gene provides a unique perspective to analyze the structural, functional, drug binding, and evolutionary aspects of T-type channels." @default.
- W2019663496 created "2016-06-24" @default.
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- W2019663496 date "2010-03-01" @default.
- W2019663496 modified "2023-10-14" @default.
- W2019663496 title "Transient and Big Are Key Features of an Invertebrate T-type Channel (LCa3) from the Central Nervous System of Lymnaea stagnalis" @default.
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- W2019663496 doi "https://doi.org/10.1074/jbc.m109.090753" @default.
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