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- W2019663984 abstract "Using sea urchin early embryos as a pertinent model, chromium(III) provoked cell cycle arrest and induced apoptosis. The molecular machinery of translation initiation was investigated. Chromium provoked a time- and dose-dependent increase in the level of 4E-BP protein, the natural regulator of the cap-dependent initiation factor 4E (eIF4E). The 4E-BP increase was the result of 4E-BP stabilization and appeared functional for physiological eIF4E binding, removal of eIF4E from the initiation factor eIF4G, and almost full inhibition of cap-dependent translation in vivo. The protein 4E-BP may be involved in the biological pathway of apoptosis associated with the activation of the DNA-damaged checkpoint of the cell cycle." @default.
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- W2019663984 date "2008-01-16" @default.
- W2019663984 modified "2023-10-12" @default.
- W2019663984 title "Chromium(III) Triggers the DNA-Damaged Checkpoint of the Cell Cycle and Induces a Functional Increase of 4E-BP" @default.
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- W2019663984 doi "https://doi.org/10.1021/tx700244h" @default.
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