Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019670585> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2019670585 endingPage "35" @default.
- W2019670585 startingPage "23" @default.
- W2019670585 abstract "This article reviews the fundamentals of myocardial energy metabolism and selectively outlines the use of several metabolically active drug therapies in the treatment of ischemic heart disease. These drugs — ranolazine, trimetazidine, dichloroacetate (DCA), glucose-insulin-potassium (GIK) solutions, and L-carnitine — have mechanisms of action distinct from traditional anti-ischemic drugs. These agents work by shifting myocardial energy metabolism away from fatty acids toward glucose as a source of fuel. Because these agents are well tolerated and do not affect heart rate or blood pressure, they conceivably could supplement traditional anti-ischemic drug therapy with little risk. The background, rationale for use, and published literature on each agent is reviewed, and the outcomes of pertinent clinical trials are discussed. In the case of ranolazine, data suggest benefit in the treatment of stable angina pectoris, particularly with sustained release formulations. Trimetazidine appears to have similar physiologic effects to ranolazine, and it is effective as monotherapy and as additive therapy in patients with chronic ischemic heart disease. DCA improves acidosis in critically ill patients and, likewise, improves myocardial hemodynamics in those with chronic coronary artery disease and congestive heart failure; however, its metabolism is variable and clinical data on its use in chronic ischemic heart disease are limited. GIK solutions have been shown to be beneficial in animal and human models of ischemia and acute myocardial infarction, and they offer an inexpensive means by which to improve the oxidation of glucose in the heart. Lastly, a large body of literature suggests a benefit with L-carnitine in a number of cardiovascular illnesses, including ischemic heart disease. Clinical trial data in acute myocardial infarction are promising and have prompted the initiation of a large-scale mortality trial." @default.
- W2019670585 created "2016-06-24" @default.
- W2019670585 creator A5055003172 @default.
- W2019670585 creator A5065481567 @default.
- W2019670585 date "2001-01-01" @default.
- W2019670585 modified "2023-10-06" @default.
- W2019670585 title "Role of Metabolically Active Drugs in the Management of Ischemic Heart Disease" @default.
- W2019670585 cites W148373708 @default.
- W2019670585 cites W1745842455 @default.
- W2019670585 cites W1974372282 @default.
- W2019670585 cites W2014260144 @default.
- W2019670585 cites W2019745630 @default.
- W2019670585 cites W2028238948 @default.
- W2019670585 cites W2040722761 @default.
- W2019670585 cites W2052129674 @default.
- W2019670585 cites W2066206978 @default.
- W2019670585 cites W2081870933 @default.
- W2019670585 cites W2148998072 @default.
- W2019670585 cites W303812557 @default.
- W2019670585 cites W50124930 @default.
- W2019670585 doi "https://doi.org/10.2165/00129784-200101010-00003" @default.
- W2019670585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14728049" @default.
- W2019670585 hasPublicationYear "2001" @default.
- W2019670585 type Work @default.
- W2019670585 sameAs 2019670585 @default.
- W2019670585 citedByCount "34" @default.
- W2019670585 countsByYear W20196705852012 @default.
- W2019670585 countsByYear W20196705852015 @default.
- W2019670585 countsByYear W20196705852016 @default.
- W2019670585 countsByYear W20196705852021 @default.
- W2019670585 countsByYear W20196705852022 @default.
- W2019670585 crossrefType "journal-article" @default.
- W2019670585 hasAuthorship W2019670585A5055003172 @default.
- W2019670585 hasAuthorship W2019670585A5065481567 @default.
- W2019670585 hasBestOaLocation W20196705851 @default.
- W2019670585 hasConcept C126322002 @default.
- W2019670585 hasConcept C164705383 @default.
- W2019670585 hasConcept C2777927741 @default.
- W2019670585 hasConcept C2778198053 @default.
- W2019670585 hasConcept C2778213512 @default.
- W2019670585 hasConcept C2778425758 @default.
- W2019670585 hasConcept C2778435403 @default.
- W2019670585 hasConcept C2779177932 @default.
- W2019670585 hasConcept C500558357 @default.
- W2019670585 hasConcept C541997718 @default.
- W2019670585 hasConcept C71924100 @default.
- W2019670585 hasConcept C98274493 @default.
- W2019670585 hasConceptScore W2019670585C126322002 @default.
- W2019670585 hasConceptScore W2019670585C164705383 @default.
- W2019670585 hasConceptScore W2019670585C2777927741 @default.
- W2019670585 hasConceptScore W2019670585C2778198053 @default.
- W2019670585 hasConceptScore W2019670585C2778213512 @default.
- W2019670585 hasConceptScore W2019670585C2778425758 @default.
- W2019670585 hasConceptScore W2019670585C2778435403 @default.
- W2019670585 hasConceptScore W2019670585C2779177932 @default.
- W2019670585 hasConceptScore W2019670585C500558357 @default.
- W2019670585 hasConceptScore W2019670585C541997718 @default.
- W2019670585 hasConceptScore W2019670585C71924100 @default.
- W2019670585 hasConceptScore W2019670585C98274493 @default.
- W2019670585 hasIssue "1" @default.
- W2019670585 hasLocation W20196705851 @default.
- W2019670585 hasLocation W20196705852 @default.
- W2019670585 hasOpenAccess W2019670585 @default.
- W2019670585 hasPrimaryLocation W20196705851 @default.
- W2019670585 hasRelatedWork W1864361583 @default.
- W2019670585 hasRelatedWork W2024094649 @default.
- W2019670585 hasRelatedWork W2048992380 @default.
- W2019670585 hasRelatedWork W2104371670 @default.
- W2019670585 hasRelatedWork W2352428042 @default.
- W2019670585 hasRelatedWork W2790353319 @default.
- W2019670585 hasRelatedWork W2964563167 @default.
- W2019670585 hasRelatedWork W4312186513 @default.
- W2019670585 hasRelatedWork W2094336700 @default.
- W2019670585 hasRelatedWork W2181599931 @default.
- W2019670585 hasVolume "1" @default.
- W2019670585 isParatext "false" @default.
- W2019670585 isRetracted "false" @default.
- W2019670585 magId "2019670585" @default.
- W2019670585 workType "article" @default.