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• W2019671935 abstract "Epstein-Barr virus (EBV) is associated with the development of a variety of highly metastatic carcinomas, including nasopharyngeal carcinoma (NPC). EBV-encoded latent membrane protein 1 (LMP1) is essential for B-cell transformation. In this study, we used two-dimensional differential gel electrophoresis (2D-DIGE) and liquid chromatography-tandem mass spectrometry (LC/MS/MS) to study the mechanism behind tumor invasion and metastasis. Eight proteins, including Vimentin and Ezrin, were identified from the alteration of expressed proteins in HEK-293 cells responding to LMP1 gene transfection. Vimentin is a major protein of the mesenchymal intermediate filament, which maintains the cytoskeleton conformation. Ezrin is also an essential protein that links the cell membrane to the actin cytoskeleton. The up-regulation of Vimentin and Ezrin in the LMP1 gene-transfected cells suggests that EBV LMP1 is involved in the progression and metastasis of NPC." @default.
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• W2019671935 date "2007-01-01" @default.
• W2019671935 modified "2023-09-24" @default.
• W2019671935 title "The Up-regulation of Vimentin and Ezrin in the Epstein-Barr Virus LMP1 Gene Transfected Cells" @default.
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• W2019671935 doi "https://doi.org/10.3950/jibiinkoka.110.24" @default.
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