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• W2019672317 abstract "Objective: To identify baseline characteristics predictive of a sustained virological response (SVR) in patients with HIV–hepatitis C virus (HCV) co-infection treated with interferon-based therapy. Design/methods: A stepwise multiple logistic regression analysis was used to explore the prognostic factors associated with SVR [undetectable HCV-RNA (< 50 IU/ml) at the end of untreated follow-up in week 72]. Results: In all patients (n = 853), in addition to the HCV therapy received, the factors most predictive of SVR were baseline HCV-RNA [≤ versus > 400 000 IU/ml; odds ratio (OR) 4.77; 95% confidence interval (CI) 3.15–7.22; P < 0.0001] and HCV genotype (OR 2.87; 95% CI 2.00–4.12; P < 0.0001). HIV treatment (with a protease inhibitor or non-nucleoside reverse transcriptase inhibitor; P = 0.034), race (P = 0.027), and body mass index (P = 0.039) were also weak predictors of HCV treatment response. Conclusions: In the AIDS PEGASYS Ribavirin International Co-infection Trial (APRICOT), the predictors of SVR among HIV–HCV co-infected patients treated with peginterferon alfa-2a plus ribavirin were similar to those in patients with HCV mono-infection. The HCV genotype and pretreatment HCV-RNA level had the greatest influence on SVR." @default.
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• W2019672317 date "2007-07-31" @default.
• W2019672317 modified "2023-10-18" @default.
• W2019672317 title "Baseline factors prognostic of sustained virological response in patients with HIV–hepatitis C virus co-infection" @default.
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• W2019672317 doi "https://doi.org/10.1097/qad.0b013e328216f2c7" @default.
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