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- W2019674668 abstract "Background: Chromosomal aneuploidy and segmental copy number changes (deletions and duplications) are a source of human diversity. This is called copy number variation (CNV). CNVs are contained in genomes of healthy individuals. And it has also revealed that some CNVs are related to disease, including several cancers. A number of studies have revealed the association various types of CNVs and breast cancer. In this study, we aimed to identify true somatic copy number change in breast cancer patients by comparing to the germline DNA of corresponding patients. Methods: Array comparative genomic hybridization (CGH) was used to examine 20 breast cancer patients. Test DNA was extracted from breast cancer tumors, and the DNA derived from peripheral blood of corresponding patient was used as reference DNA. Results: A total of 4162 CNVs were detected, and 3263(78.3%) overlapped one or more gene coding legions. Some of those showed the copy number change of part of gene including exons, and some involved whole gene or whole chromosome. A number of copy number breakpoints were found within a gene, which might have gene fusions. Chromosomal regions at 1q44 and 8q23.3, where TRPS1 located in, were most frequently gained (75%).In our laboratory, the CGH analysis of bladder cancer and cholangiocarcinoma samples have been performed, and more, head and neck cancer samples are currently under analysis. We are continuing analyze the data and the result, which includes the detail of CNVs of breast cancer and comparison of CNVs among these cancers, will be reported." @default.
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- W2019674668 date "2013-11-01" @default.
- W2019674668 modified "2023-10-01" @default.
- W2019674668 title "Analysis of Copy Number Aberration in Breast Cancer" @default.
- W2019674668 doi "https://doi.org/10.1093/annonc/mdt459.87" @default.
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