FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019675656> ?p ?o ?g. }

• W2019675656 endingPage "146" @default.
• W2019675656 startingPage "140" @default.
• W2019675656 abstract "The failure of HIV-1 to escape at some cytotoxic T-lymphocyte (CTL) epitopes has generally been explained in terms of viral fitness costs or ineffective or attenuated CTL responses. Relatively little attention has been paid to the evolutionary time required for escape mutants to be detected. This time is significantly affected by selection, mutation rates, the presence of other advantageous mutations, and the effective population size of HIV-1 in vivo (typically estimated to be approximately 10(3) in chronically infected patients, though one study has estimated it to be approximately 10(5)). Here, we use a forward simulator with experimentally estimated HIV-1 parameters to show that these delays can be substantial. For an effective population size of 10(3), even highly advantageous mutants (s = 0.5) may not be detected for a couple of years in chronically infected patients, while moderately advantageous escape mutants (s = 0.1) may not be detected for up to 10 years. Even with an effective population size of 10(5), a moderately advantageous escape mutant (s = 0.1) may not be detected in the population within 2 years if it has to compete with other selectively advantageous mutants. Stochastic evolutionary forces, therefore, in addition to viral fitness costs and ineffective or attenuated CTL responses, must be taken into account when assessing the selection of CTL escape mutations." @default.
• W2019675656 created "2016-06-24" @default.
• W2019675656 creator A5008659449 @default.
• W2019675656 creator A5018660762 @default.
• W2019675656 creator A5028336562 @default.
• W2019675656 date "2006-03-01" @default.
• W2019675656 modified "2023-10-18" @default.
• W2019675656 title "Waiting times for the appearance of cytotoxic T-lymphocyte escape mutants in chronic HIV-1 infection" @default.
• W2019675656 cites W1655510925 @default.
• W2019675656 cites W1847861803 @default.
• W2019675656 cites W1955688637 @default.
• W2019675656 cites W1974839791 @default.
• W2019675656 cites W1982200480 @default.
• W2019675656 cites W1986152436 @default.
• W2019675656 cites W2017172508 @default.
• W2019675656 cites W2022098233 @default.
• W2019675656 cites W2037450520 @default.
• W2019675656 cites W2041469490 @default.
• W2019675656 cites W2048560524 @default.
• W2019675656 cites W2058047903 @default.
• W2019675656 cites W2060382143 @default.
• W2019675656 cites W2063485002 @default.
• W2019675656 cites W2079504777 @default.
• W2019675656 cites W2085919513 @default.
• W2019675656 cites W2088567145 @default.
• W2019675656 cites W2089573804 @default.
• W2019675656 cites W2095983332 @default.
• W2019675656 cites W2099182602 @default.
• W2019675656 cites W2103182811 @default.
• W2019675656 cites W2107138643 @default.
• W2019675656 cites W2107786521 @default.
• W2019675656 cites W2108504053 @default.
• W2019675656 cites W2112601022 @default.
• W2019675656 cites W2117623876 @default.
• W2019675656 cites W2120011479 @default.
• W2019675656 cites W2120915945 @default.
• W2019675656 cites W2129114331 @default.
• W2019675656 cites W2129672006 @default.
• W2019675656 cites W2133402813 @default.
• W2019675656 cites W2139185068 @default.
• W2019675656 cites W2142316620 @default.
• W2019675656 cites W2149492547 @default.
• W2019675656 cites W2154283429 @default.
• W2019675656 cites W2168736565 @default.
• W2019675656 cites W2170219825 @default.
• W2019675656 cites W2171463101 @default.
• W2019675656 cites W4295837538 @default.
• W2019675656 doi "https://doi.org/10.1016/j.virol.2005.11.036" @default.
• W2019675656 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16387340" @default.
• W2019675656 hasPublicationYear "2006" @default.
• W2019675656 type Work @default.
• W2019675656 sameAs 2019675656 @default.
• W2019675656 citedByCount "21" @default.
• W2019675656 countsByYear W20196756562013 @default.
• W2019675656 countsByYear W20196756562014 @default.
• W2019675656 countsByYear W20196756562015 @default.
• W2019675656 crossrefType "journal-article" @default.
• W2019675656 hasAuthorship W2019675656A5008659449 @default.
• W2019675656 hasAuthorship W2019675656A5018660762 @default.
• W2019675656 hasAuthorship W2019675656A5028336562 @default.
• W2019675656 hasBestOaLocation W20196756561 @default.
• W2019675656 hasConcept C104317684 @default.
• W2019675656 hasConcept C143065580 @default.
• W2019675656 hasConcept C144024400 @default.
• W2019675656 hasConcept C147969180 @default.
• W2019675656 hasConcept C149923435 @default.
• W2019675656 hasConcept C154317977 @default.
• W2019675656 hasConcept C159047783 @default.
• W2019675656 hasConcept C202751555 @default.
• W2019675656 hasConcept C203014093 @default.
• W2019675656 hasConcept C2908647359 @default.
• W2019675656 hasConcept C2910387474 @default.
• W2019675656 hasConcept C2988562018 @default.
• W2019675656 hasConcept C501734568 @default.
• W2019675656 hasConcept C54355233 @default.
• W2019675656 hasConcept C86803240 @default.
• W2019675656 hasConcept C98638677 @default.
• W2019675656 hasConceptScore W2019675656C104317684 @default.
• W2019675656 hasConceptScore W2019675656C143065580 @default.
• W2019675656 hasConceptScore W2019675656C144024400 @default.
• W2019675656 hasConceptScore W2019675656C147969180 @default.
• W2019675656 hasConceptScore W2019675656C149923435 @default.
• W2019675656 hasConceptScore W2019675656C154317977 @default.
• W2019675656 hasConceptScore W2019675656C159047783 @default.
• W2019675656 hasConceptScore W2019675656C202751555 @default.
• W2019675656 hasConceptScore W2019675656C203014093 @default.
• W2019675656 hasConceptScore W2019675656C2908647359 @default.
• W2019675656 hasConceptScore W2019675656C2910387474 @default.
• W2019675656 hasConceptScore W2019675656C2988562018 @default.
• W2019675656 hasConceptScore W2019675656C501734568 @default.
• W2019675656 hasConceptScore W2019675656C54355233 @default.
• W2019675656 hasConceptScore W2019675656C86803240 @default.
• W2019675656 hasConceptScore W2019675656C98638677 @default.
• W2019675656 hasIssue "1" @default.
• W2019675656 hasLocation W20196756561 @default.
• W2019675656 hasLocation W20196756562 @default.
• W2019675656 hasOpenAccess W2019675656 @default.
• W2019675656 hasPrimaryLocation W20196756561 @default.

• next