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• W2019677428 endingPage "352" @default.
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• W2019677428 abstract "• AgNO 3 and bare AgNPs have similar toxicities whereas PVP-coating reduces the toxicity. • Different responses of mutants suggest the distinct toxic mechanism of AgNO 3 and AgNPs. • AgNO 3 and AgNPs induce oxidative stress-related mitochondrial DNA damage. This study examined the effects of polyvinylpyrrolidone (PVP) surface coating and size on the organismal and molecular toxicity of silver nanoparticles (AgNPs) on the nematode, Caenorhabditis elegans . The toxicity of bare AgNPs and 8 and 38 nm PVP-coated AgNPs (PVP8-AgNPs, PVP38-AgNPs) were compared. The toxicity of AgNO 3 was also tested because ion dissolution and particle-specific effects are often important characteristics determining Ag nanotoxicity. Comparative toxicity across AgNO 3 and the three different types of AgNPs was first evaluated using a C. elegans mortality test by a direct comparison of the LC 50 values. Subsequently, mutant screening followed by oxidative stress, mitochondrial toxicity and DNA damage assays were carried out at equitoxic (LC 10 and LC 50 ) concentrations to further assess the toxicity mechanism of AgNO 3 and AgNPs. AgNO 3 and bare AgNPs had similar toxicities, whereas PVP coating reduced the toxicity of the AgNPs significantly. Of the PVP-AgNPs, the smaller NPs were more toxic. Different groups of mutants responded differently to AgNO 3 and AgNPs, which indicates that their toxicity mechanism might be different. AgNO 3 and bare AgNPs induced mitochondrial membrane damage. None of the silver materials tested caused detectable polymerase-inhibiting DNA lesions in either the nucleus or mitochondria as measured by a quantitative PCR assay, but AgNO 3 , bare AgNPs and PVP8-AgNPs induced oxidative DNA damage. These results show that coatings on the AgNPs surface and the particle size make a clear contribution to the toxicity of the AgNPs, and oxidative stress-related mitochondrial and DNA damage appear to be potential mechanisms of toxicity." @default.
• W2019677428 created "2016-06-24" @default.
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• W2019677428 date "2014-08-01" @default.
• W2019677428 modified "2023-10-16" @default.
• W2019677428 title "Comparative toxicity of silver nanoparticles on oxidative stress and DNA damage in the nematode, Caenorhabditis elegans" @default.
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• W2019677428 doi "https://doi.org/10.1016/j.chemosphere.2014.01.078" @default.
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