Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019681640> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2019681640 endingPage "726a" @default.
- W2019681640 startingPage "726a" @default.
- W2019681640 abstract "Filopodia are thin actin-rich plasma membrane structures found at the leading edge of migrating cells. Filopodia protrusions are regulated in part by myosin X, an unconventional myosin with a FERM domain that interacts with the adhesion factor integrin-β.We have previously found the long filopodia needed for cell adhesion were produced by having filopodia repeat cycles of short (∼3um) extensions and retractions (phased elongation). This phased elongation could be suppressed by deleting the FERM domain. This result indicates that filopodia protrusion mediated by myosin-X is strongly responsible for cell adhesion.To further investigate the importance of the FERM domain, we have examined the effects of substrate coating on filopodia. Two types of substrate coating, fibronectin and poly-lysine, were used. Fibronectin is an extracellular matrix glycoprotein that binds to integrins (integrin dependent), while poly-lysine is a synthetic molecules used to enhance cell attachment to plastic and glass surfaces (integrin independent). We found that the protrusion velocity of filopodia on fibronectin was less than that on poly-lysine, which is likely due to friction between the FERM domain and integrin.Also, the filopodia length of one elongation (one extension and retraction) on fibronectin was 1.5 fold longer than that on poly-lysine. However, this was compensated for by the number of phased elongation resulting in approximately equal filopodia lengths regardless of the substrate coating.We are now observing the movement of myosin-X lacking FERM domain using the same substrate coatings. At this meeting, we will compare these results with the above in detail." @default.
- W2019681640 created "2016-06-24" @default.
- W2019681640 creator A5000190356 @default.
- W2019681640 creator A5062493641 @default.
- W2019681640 creator A5083605341 @default.
- W2019681640 creator A5091114288 @default.
- W2019681640 date "2010-01-01" @default.
- W2019681640 modified "2023-09-28" @default.
- W2019681640 title "The Effect of the Interaction Between the Myosin-X Ferm Domain and Integrin on Filopodia Protrusion" @default.
- W2019681640 doi "https://doi.org/10.1016/j.bpj.2009.12.3977" @default.
- W2019681640 hasPublicationYear "2010" @default.
- W2019681640 type Work @default.
- W2019681640 sameAs 2019681640 @default.
- W2019681640 citedByCount "0" @default.
- W2019681640 crossrefType "journal-article" @default.
- W2019681640 hasAuthorship W2019681640A5000190356 @default.
- W2019681640 hasAuthorship W2019681640A5062493641 @default.
- W2019681640 hasAuthorship W2019681640A5083605341 @default.
- W2019681640 hasAuthorship W2019681640A5091114288 @default.
- W2019681640 hasBestOaLocation W20196816401 @default.
- W2019681640 hasConcept C12554922 @default.
- W2019681640 hasConcept C125705527 @default.
- W2019681640 hasConcept C144647389 @default.
- W2019681640 hasConcept C1491633281 @default.
- W2019681640 hasConcept C161200384 @default.
- W2019681640 hasConcept C178790620 @default.
- W2019681640 hasConcept C185592680 @default.
- W2019681640 hasConcept C189165786 @default.
- W2019681640 hasConcept C195687474 @default.
- W2019681640 hasConcept C200342125 @default.
- W2019681640 hasConcept C41625074 @default.
- W2019681640 hasConcept C55493867 @default.
- W2019681640 hasConcept C6997183 @default.
- W2019681640 hasConcept C84416704 @default.
- W2019681640 hasConcept C85789140 @default.
- W2019681640 hasConcept C86492073 @default.
- W2019681640 hasConcept C86803240 @default.
- W2019681640 hasConcept C90301020 @default.
- W2019681640 hasConcept C95444343 @default.
- W2019681640 hasConceptScore W2019681640C12554922 @default.
- W2019681640 hasConceptScore W2019681640C125705527 @default.
- W2019681640 hasConceptScore W2019681640C144647389 @default.
- W2019681640 hasConceptScore W2019681640C1491633281 @default.
- W2019681640 hasConceptScore W2019681640C161200384 @default.
- W2019681640 hasConceptScore W2019681640C178790620 @default.
- W2019681640 hasConceptScore W2019681640C185592680 @default.
- W2019681640 hasConceptScore W2019681640C189165786 @default.
- W2019681640 hasConceptScore W2019681640C195687474 @default.
- W2019681640 hasConceptScore W2019681640C200342125 @default.
- W2019681640 hasConceptScore W2019681640C41625074 @default.
- W2019681640 hasConceptScore W2019681640C55493867 @default.
- W2019681640 hasConceptScore W2019681640C6997183 @default.
- W2019681640 hasConceptScore W2019681640C84416704 @default.
- W2019681640 hasConceptScore W2019681640C85789140 @default.
- W2019681640 hasConceptScore W2019681640C86492073 @default.
- W2019681640 hasConceptScore W2019681640C86803240 @default.
- W2019681640 hasConceptScore W2019681640C90301020 @default.
- W2019681640 hasConceptScore W2019681640C95444343 @default.
- W2019681640 hasIssue "3" @default.
- W2019681640 hasLocation W20196816401 @default.
- W2019681640 hasOpenAccess W2019681640 @default.
- W2019681640 hasPrimaryLocation W20196816401 @default.
- W2019681640 hasRelatedWork W1844137891 @default.
- W2019681640 hasRelatedWork W1963502181 @default.
- W2019681640 hasRelatedWork W1964265166 @default.
- W2019681640 hasRelatedWork W1975367470 @default.
- W2019681640 hasRelatedWork W1986561157 @default.
- W2019681640 hasRelatedWork W1988911023 @default.
- W2019681640 hasRelatedWork W1999515737 @default.
- W2019681640 hasRelatedWork W1999707554 @default.
- W2019681640 hasRelatedWork W2004753542 @default.
- W2019681640 hasRelatedWork W2017784555 @default.
- W2019681640 hasRelatedWork W2069199145 @default.
- W2019681640 hasRelatedWork W2072058530 @default.
- W2019681640 hasRelatedWork W2113491370 @default.
- W2019681640 hasRelatedWork W2479401215 @default.
- W2019681640 hasRelatedWork W2580005421 @default.
- W2019681640 hasRelatedWork W2595854251 @default.
- W2019681640 hasRelatedWork W2925642273 @default.
- W2019681640 hasRelatedWork W3082410354 @default.
- W2019681640 hasRelatedWork W3138722636 @default.
- W2019681640 hasRelatedWork W41353385 @default.
- W2019681640 hasVolume "98" @default.
- W2019681640 isParatext "false" @default.
- W2019681640 isRetracted "false" @default.
- W2019681640 magId "2019681640" @default.
- W2019681640 workType "article" @default.