FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019686079> ?p ?o ?g. }

• W2019686079 endingPage "85" @default.
• W2019686079 startingPage "79" @default.
• W2019686079 abstract "The present study focused on investigating the antidepressant potential of tetrandrine and its possible mechanisms of action. Forced swimming test (FST) and tail suspension test (TST) were used to reveal the antidepressant-like effect of tetrandrine. Potential mechanisms were explored applying reserpine-induced ptosis and hypothermia in mice, as well as using the chronic unpredictable mild stress (CUMS) induced depression model in rats. Tetrandrine reduced immobility time in both the FST and TST and antagonized reserpine-induced ptosis and hypothermia in mice. The concentrations of 5-hydroxytryptamine (5-HT) and norepinephrine (NE) in mice hippocampi decreased after the administration of reserpine. However, pre-treatments with tetrandrine significantly increased the concentrations of 5-HT and NE in mice hippocampi. In the CUMS-induced depressive rats, bodyweight, 1% sucrose consumption and the concentrations of 5-HT and NE in hippocampi decreased significantly compared with the normal control group. However, these changes could be significantly reversed by tetrandrine application. Furthermore, the levels of the brain-derived neurotrophic factor (BDNF) in hippocampi increased in the tetrandrine-treated rats exposed to CUMS. In summary, our findings suggest that the antidepressant-like effect of tetrandrine is involved in the regulation of the central monoaminergic neurotransmitter system and the levels of BDNF." @default.
• W2019686079 created "2016-06-24" @default.
• W2019686079 creator A5007726323 @default.
• W2019686079 creator A5036697924 @default.
• W2019686079 creator A5082117229 @default.
• W2019686079 creator A5091392771 @default.
• W2019686079 date "2013-02-01" @default.
• W2019686079 modified "2023-10-18" @default.
• W2019686079 title "Tetrandrine exerts antidepressant-like effects in animal models: Role of brain-derived neurotrophic factor" @default.
• W2019686079 cites W1971045606 @default.
• W2019686079 cites W1976194465 @default.
• W2019686079 cites W1982619661 @default.
• W2019686079 cites W1988704615 @default.
• W2019686079 cites W1988904708 @default.
• W2019686079 cites W1989624492 @default.
• W2019686079 cites W1995556701 @default.
• W2019686079 cites W2000273941 @default.
• W2019686079 cites W2004118951 @default.
• W2019686079 cites W2005594217 @default.
• W2019686079 cites W2014394457 @default.
• W2019686079 cites W2033314153 @default.
• W2019686079 cites W2035421865 @default.
• W2019686079 cites W2036114299 @default.
• W2019686079 cites W2041252693 @default.
• W2019686079 cites W2041352084 @default.
• W2019686079 cites W2043563630 @default.
• W2019686079 cites W2044154925 @default.
• W2019686079 cites W2050836998 @default.
• W2019686079 cites W2075620663 @default.
• W2019686079 cites W2086656730 @default.
• W2019686079 cites W2086702415 @default.
• W2019686079 cites W2107277218 @default.
• W2019686079 cites W2128837905 @default.
• W2019686079 cites W2129579709 @default.
• W2019686079 cites W2142786903 @default.
• W2019686079 cites W2150640010 @default.
• W2019686079 cites W2152306843 @default.
• W2019686079 cites W2167815351 @default.
• W2019686079 cites W2168080346 @default.
• W2019686079 cites W2793634050 @default.
• W2019686079 doi "https://doi.org/10.1016/j.bbr.2012.10.015" @default.
• W2019686079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23085478" @default.
• W2019686079 hasPublicationYear "2013" @default.
• W2019686079 type Work @default.
• W2019686079 sameAs 2019686079 @default.
• W2019686079 citedByCount "40" @default.
• W2019686079 countsByYear W20196860792013 @default.
• W2019686079 countsByYear W20196860792014 @default.
• W2019686079 countsByYear W20196860792015 @default.
• W2019686079 countsByYear W20196860792016 @default.
• W2019686079 countsByYear W20196860792017 @default.
• W2019686079 countsByYear W20196860792019 @default.
• W2019686079 countsByYear W20196860792020 @default.
• W2019686079 countsByYear W20196860792021 @default.
• W2019686079 countsByYear W20196860792022 @default.
• W2019686079 countsByYear W20196860792023 @default.
• W2019686079 crossrefType "journal-article" @default.
• W2019686079 hasAuthorship W2019686079A5007726323 @default.
• W2019686079 hasAuthorship W2019686079A5036697924 @default.
• W2019686079 hasAuthorship W2019686079A5082117229 @default.
• W2019686079 hasAuthorship W2019686079A5091392771 @default.
• W2019686079 hasConcept C126322002 @default.
• W2019686079 hasConcept C134018914 @default.
• W2019686079 hasConcept C136569192 @default.
• W2019686079 hasConcept C142724271 @default.
• W2019686079 hasConcept C160539049 @default.
• W2019686079 hasConcept C170493617 @default.
• W2019686079 hasConcept C185592680 @default.
• W2019686079 hasConcept C204787440 @default.
• W2019686079 hasConcept C2776219046 @default.
• W2019686079 hasConcept C2777390192 @default.
• W2019686079 hasConcept C2777842393 @default.
• W2019686079 hasConcept C2778790584 @default.
• W2019686079 hasConcept C2778875871 @default.
• W2019686079 hasConcept C2779145073 @default.
• W2019686079 hasConcept C2779177272 @default.
• W2019686079 hasConcept C2779305415 @default.
• W2019686079 hasConcept C2779934757 @default.
• W2019686079 hasConcept C2781001258 @default.
• W2019686079 hasConcept C2781161787 @default.
• W2019686079 hasConcept C71924100 @default.
• W2019686079 hasConcept C98274493 @default.
• W2019686079 hasConceptScore W2019686079C126322002 @default.
• W2019686079 hasConceptScore W2019686079C134018914 @default.
• W2019686079 hasConceptScore W2019686079C136569192 @default.
• W2019686079 hasConceptScore W2019686079C142724271 @default.
• W2019686079 hasConceptScore W2019686079C160539049 @default.
• W2019686079 hasConceptScore W2019686079C170493617 @default.
• W2019686079 hasConceptScore W2019686079C185592680 @default.
• W2019686079 hasConceptScore W2019686079C204787440 @default.
• W2019686079 hasConceptScore W2019686079C2776219046 @default.
• W2019686079 hasConceptScore W2019686079C2777390192 @default.
• W2019686079 hasConceptScore W2019686079C2777842393 @default.
• W2019686079 hasConceptScore W2019686079C2778790584 @default.
• W2019686079 hasConceptScore W2019686079C2778875871 @default.
• W2019686079 hasConceptScore W2019686079C2779145073 @default.
• W2019686079 hasConceptScore W2019686079C2779177272 @default.
• W2019686079 hasConceptScore W2019686079C2779305415 @default.

• next