FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019688051> ?p ?o ?g. }

• W2019688051 endingPage "5434" @default.
• W2019688051 startingPage "5423" @default.
• W2019688051 abstract "Abstract Purpose: Non–small cell lung cancers (NSCLC) that express EGF receptor with activating mutations frequently develop resistance to EGFR kinase inhibitors. The mucin 1 (MUC1) heterodimeric protein is aberrantly overexpressed in NSCLC cells and confers a poor prognosis; however, the functional involvement of MUC1 in mutant EGFR signaling is not known. Experimental Design: Targeting the oncogenic MUC1 C-terminal subunit (MUC1-C) in NSCLC cells harboring mutant EGFR was studied for effects on signaling, growth, clonogenic survival, and tumorigenicity. Results: Stable silencing of MUC1-C in H1975/EGFR(L858R/T790M) cells resulted in downregulation of AKT signaling and inhibition of growth, colony formation, and tumorigenicity. Similar findings were obtained when MUC1-C was silenced in gefitinib-resistant PC9GR cells expressing EGFR(delE746_A750/T790M). The results further show that expression of a MUC1-C(CQC→AQA) mutant, which blocks MUC1-C homodimerization, suppresses EGFR(T790M), AKT and MEK→ERK activation, colony formation, and tumorigenicity. In concert with these results, treatment of H1975 and PC9GR cells with GO-203, a cell-penetrating peptide that blocks MUC1-C homodimerization, resulted in inhibition of EGFR, AKT, and MEK→ERK signaling and in loss of survival. Combination studies of GO-203 and afatinib, an irreversible inhibitor of EGFR, further demonstrate that these agents are synergistic in inhibiting growth of NSCLC cells harboring the activating EGFR(T790M) or EGFR(delE746-A750) mutants. Conclusions: These findings indicate that targeting MUC1-C inhibits mutant EGFR signaling and survival, and thus represents a potential approach alone and in combination for the treatment of NSCLCs resistant to EGFR kinase inhibitors. Clin Cancer Res; 20(21); 5423–34. ©2014 AACR." @default.
• W2019688051 created "2016-06-24" @default.
• W2019688051 creator A5010364407 @default.
• W2019688051 creator A5019034689 @default.
• W2019688051 creator A5049199395 @default.
• W2019688051 creator A5049901416 @default.
• W2019688051 creator A5067054634 @default.
• W2019688051 creator A5076506991 @default.
• W2019688051 creator A5076790826 @default.
• W2019688051 date "2014-10-30" @default.
• W2019688051 modified "2023-09-28" @default.
• W2019688051 title "Targeting the Oncogenic MUC1-C Protein Inhibits Mutant EGFR-Mediated Signaling and Survival in Non–Small Cell Lung Cancer Cells" @default.
• W2019688051 cites W1522833171 @default.
• W2019688051 cites W1964978938 @default.
• W2019688051 cites W1967394241 @default.
• W2019688051 cites W1974303565 @default.
• W2019688051 cites W1987384630 @default.
• W2019688051 cites W1989897633 @default.
• W2019688051 cites W1994305679 @default.
• W2019688051 cites W1996344455 @default.
• W2019688051 cites W2002937040 @default.
• W2019688051 cites W2003984225 @default.
• W2019688051 cites W2012204343 @default.
• W2019688051 cites W2012934075 @default.
• W2019688051 cites W2016956014 @default.
• W2019688051 cites W2018578974 @default.
• W2019688051 cites W2021312892 @default.
• W2019688051 cites W2023752535 @default.
• W2019688051 cites W2034102636 @default.
• W2019688051 cites W2034451570 @default.
• W2019688051 cites W2040575339 @default.
• W2019688051 cites W2052953366 @default.
• W2019688051 cites W2060162605 @default.
• W2019688051 cites W2060345044 @default.
• W2019688051 cites W2063391304 @default.
• W2019688051 cites W2067001456 @default.
• W2019688051 cites W2067634655 @default.
• W2019688051 cites W2076370383 @default.
• W2019688051 cites W2077154885 @default.
• W2019688051 cites W2085137844 @default.
• W2019688051 cites W2087955215 @default.
• W2019688051 cites W2096198395 @default.
• W2019688051 cites W2096439168 @default.
• W2019688051 cites W2099775353 @default.
• W2019688051 cites W2107026633 @default.
• W2019688051 cites W2110841878 @default.
• W2019688051 cites W2114857075 @default.
• W2019688051 cites W2130473918 @default.
• W2019688051 cites W2143913849 @default.
• W2019688051 cites W2146426819 @default.
• W2019688051 cites W2151382001 @default.
• W2019688051 cites W2152905269 @default.
• W2019688051 cites W2155228605 @default.
• W2019688051 cites W2160300997 @default.
• W2019688051 cites W2164740289 @default.
• W2019688051 cites W2167210788 @default.
• W2019688051 cites W2168121702 @default.
• W2019688051 cites W2169816570 @default.
• W2019688051 cites W2332183914 @default.
• W2019688051 doi "https://doi.org/10.1158/1078-0432.ccr-13-3168" @default.
• W2019688051 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4219601" @default.
• W2019688051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25189483" @default.
• W2019688051 hasPublicationYear "2014" @default.
• W2019688051 type Work @default.
• W2019688051 sameAs 2019688051 @default.
• W2019688051 citedByCount "57" @default.
• W2019688051 countsByYear W20196880512015 @default.
• W2019688051 countsByYear W20196880512016 @default.
• W2019688051 countsByYear W20196880512017 @default.
• W2019688051 countsByYear W20196880512018 @default.
• W2019688051 countsByYear W20196880512019 @default.
• W2019688051 countsByYear W20196880512020 @default.
• W2019688051 countsByYear W20196880512021 @default.
• W2019688051 countsByYear W20196880512022 @default.
• W2019688051 countsByYear W20196880512023 @default.
• W2019688051 crossrefType "journal-article" @default.
• W2019688051 hasAuthorship W2019688051A5010364407 @default.
• W2019688051 hasAuthorship W2019688051A5019034689 @default.
• W2019688051 hasAuthorship W2019688051A5049199395 @default.
• W2019688051 hasAuthorship W2019688051A5049901416 @default.
• W2019688051 hasAuthorship W2019688051A5067054634 @default.
• W2019688051 hasAuthorship W2019688051A5076506991 @default.
• W2019688051 hasAuthorship W2019688051A5076790826 @default.
• W2019688051 hasBestOaLocation W20196880511 @default.
• W2019688051 hasConcept C121608353 @default.
• W2019688051 hasConcept C126322002 @default.
• W2019688051 hasConcept C185592680 @default.
• W2019688051 hasConcept C2777421810 @default.
• W2019688051 hasConcept C2777506169 @default.
• W2019688051 hasConcept C2777930144 @default.
• W2019688051 hasConcept C2779438470 @default.
• W2019688051 hasConcept C2780580887 @default.
• W2019688051 hasConcept C502942594 @default.
• W2019688051 hasConcept C55493867 @default.
• W2019688051 hasConcept C57074206 @default.
• W2019688051 hasConcept C62112901 @default.
• W2019688051 hasConcept C62478195 @default.
• W2019688051 hasConcept C71924100 @default.

• next