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• W2019688531 endingPage "23" @default.
• W2019688531 startingPage "14" @default.
• W2019688531 abstract "The Notch proteins encompass a family of transmembrane receptors that have been highly conserved through evolution as mediators of cell fate, and are comprised of 4 members in mammals (Notch1 to Notch4). Following intra cellular processing of the full-length protein, Notch is expressed at the cell surface as a heterodimeric receptor. Engagement by ligand results in a 2-step cleavage of the Notch heterodimer, releasing the intracellular domain of Notch and allowing translocation to the nucleus. The intracellular domain of Notch interacts with the DNA-binding factor, CSL, resulting in transactivation at various promoters, in particular those of various basic helix-loop-helix factors of the HES (Hairy and Enhancer of Split) and HRT families (Hairy-Related Transcription factor). Recent findings implicate Notch as playing a critical and non-redundant role in vascular development and maintenance. This article briefly reviews vessel development and Notch signaling and highlights studies that examine Notch functions such as proliferation, cell survival, migration, adhesion, and mesenchymal transformation in the vasculature. Human diseases caused by Notch pathway members are also discussed." @default.
• W2019688531 created "2016-06-24" @default.
• W2019688531 creator A5083812935 @default.
• W2019688531 date "2005-01-01" @default.
• W2019688531 modified "2023-09-25" @default.
• W2019688531 title "The role of notch in modeling and maintaining the vasculature" @default.
• W2019688531 cites W1495287184 @default.
• W2019688531 cites W1507499648 @default.
• W2019688531 cites W157586078 @default.
• W2019688531 cites W1643497640 @default.
• W2019688531 cites W1679229092 @default.
• W2019688531 cites W1796060835 @default.
• W2019688531 cites W1844115570 @default.
• W2019688531 cites W1956254370 @default.
• W2019688531 cites W1964461246 @default.
• W2019688531 cites W1964560807 @default.
• W2019688531 cites W1965963514 @default.
• W2019688531 cites W1968068296 @default.
• W2019688531 cites W1968614642 @default.
• W2019688531 cites W1971187999 @default.
• W2019688531 cites W1971728441 @default.
• W2019688531 cites W1972063476 @default.
• W2019688531 cites W1974185766 @default.
• W2019688531 cites W1975236596 @default.
• W2019688531 cites W1976305272 @default.
• W2019688531 cites W1977474446 @default.
• W2019688531 cites W1982412998 @default.
• W2019688531 cites W1983867285 @default.
• W2019688531 cites W1985782363 @default.
• W2019688531 cites W1985920188 @default.
• W2019688531 cites W1986155425 @default.
• W2019688531 cites W1988368236 @default.
• W2019688531 cites W1989292359 @default.
• W2019688531 cites W1991506501 @default.
• W2019688531 cites W1992959024 @default.
• W2019688531 cites W2005349546 @default.
• W2019688531 cites W2005971799 @default.
• W2019688531 cites W2011838341 @default.
• W2019688531 cites W2013480667 @default.
• W2019688531 cites W2017719081 @default.
• W2019688531 cites W2019281801 @default.
• W2019688531 cites W2022892939 @default.
• W2019688531 cites W2023188066 @default.
• W2019688531 cites W2023205404 @default.
• W2019688531 cites W2026827095 @default.
• W2019688531 cites W2028817453 @default.
• W2019688531 cites W2030367654 @default.
• W2019688531 cites W2036311400 @default.
• W2019688531 cites W2039260492 @default.
• W2019688531 cites W2039922719 @default.
• W2019688531 cites W2050787789 @default.
• W2019688531 cites W2051319925 @default.
• W2019688531 cites W2053938092 @default.
• W2019688531 cites W2058734213 @default.
• W2019688531 cites W2061634271 @default.
• W2019688531 cites W2066551239 @default.
• W2019688531 cites W2068620822 @default.
• W2019688531 cites W2069441085 @default.
• W2019688531 cites W2071196711 @default.
• W2019688531 cites W2074575987 @default.
• W2019688531 cites W2078497756 @default.
• W2019688531 cites W2078767245 @default.
• W2019688531 cites W2082133442 @default.
• W2019688531 cites W2083800064 @default.
• W2019688531 cites W2084260830 @default.
• W2019688531 cites W2085300891 @default.
• W2019688531 cites W2085682228 @default.
• W2019688531 cites W2089808577 @default.
• W2019688531 cites W2090883050 @default.
• W2019688531 cites W2091574626 @default.
• W2019688531 cites W2092034939 @default.
• W2019688531 cites W2096481282 @default.
• W2019688531 cites W2097466570 @default.
• W2019688531 cites W2098722719 @default.
• W2019688531 cites W2101542976 @default.
• W2019688531 cites W2103267380 @default.
• W2019688531 cites W2105029970 @default.
• W2019688531 cites W2108491220 @default.
• W2019688531 cites W2109179142 @default.
• W2019688531 cites W2110066617 @default.
• W2019688531 cites W2116087542 @default.
• W2019688531 cites W2118702666 @default.
• W2019688531 cites W2126659307 @default.
• W2019688531 cites W2131655610 @default.
• W2019688531 cites W2132815970 @default.
• W2019688531 cites W2133391255 @default.
• W2019688531 cites W2133469704 @default.
• W2019688531 cites W2145832243 @default.
• W2019688531 cites W2146445411 @default.
• W2019688531 cites W2146660065 @default.
• W2019688531 cites W2153287135 @default.
• W2019688531 cites W2153360321 @default.
• W2019688531 cites W2157244334 @default.
• W2019688531 cites W2157340896 @default.
• W2019688531 cites W2157893542 @default.
• W2019688531 cites W2157951377 @default.
• W2019688531 cites W2158509547 @default.
• W2019688531 cites W2160066279 @default.

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