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• W2019689969 abstract "Abstract Background Peripheral T‐cell lymphomas (PTCL) are very rare in children and this has prevented assessment of best treatment and prognosis. Procedure Registry‐based experience in England, Scotland and Wales over a 20‐year period was studied to address these shortfalls. Anaplastic large cell lymphoma and mycosis fungoides were excluded due to recent publications describing UK experience with these disorders. Results Twenty‐five cases were identified, comprising 1.6% of non‐Hodgkin lymphoma (NHL) registrations; 17 (68%) children with PTCL‐unspecified (PTCL‐u), 3 (12%) with angiocentric PTCL, 3 (12%) with angioimmunoblastic PTCL, and 2 (8%) with subcutaneous panniculitis‐like T‐cell lymphoma. Eighteen children were male, with a male/female ratio of 2.6:1. Median age was 7 (range 1–14) years. Eleven children (44%) died and actuarial survival was 76% at 1 year, 64% at 3 years and 59% at 5 years. Treatments given were subdivided between group T (regimens for T NHL or acute lymphoblastic leukaemia) or group B (regimens for B NHL). Amongst the 17 children with PTCL‐u, 9/12 children in group T survived compared with 1/5 group B. Conclusions The Children's Cancer and Leukaemia Group recommendation that children with PTCL‐u receive group T therapy is supported by this series. The numbers of children with other types of PTCL were too small to allow conclusions on best therapy. Pediatr Blood Cancer 2008;50:784–787. © 2007 Wiley‐Liss, Inc." @default.
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• W2019689969 date "2007-11-16" @default.
• W2019689969 modified "2023-10-18" @default.
• W2019689969 title "Peripheral T-cell lymphoma in childhood: Population-based experience in the United Kingdom over 20 years" @default.
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• W2019689969 doi "https://doi.org/10.1002/pbc.21293" @default.
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