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- W2019692020 abstract "Previous experiments demonstrated that excitatory amino acids participate in the osmotic regulation of vasopressin secretion, but the specific involvement of N ‐methyl‐ d ‐aspartic acid (NMDA) receptors was not evaluated. This was demonstrated in the present studies. NMDA stimulated vasopressin release from perifused explants of the hypothalamo‐neurohypophyseal system (HNS), and osmotic stimulation of vasopressin release was inhibited by MK‐801 (10 μM) and AP5 (100 μM) NMDA receptor antagonists. The effective concentration of NMDA was dependent upon the Mg 2+ concentration of the perifusate with stimulation observed at 1 μM NMDA in Mg 2+ ‐replete compared with 5 μM in low‐Mg 2+ medium. Previous experiments also demonstrated that estradiol and dihydrotestosterone (DHT) inhibited osmotically stimulated vasopressin secretion, and a nongenomic mechanism of action was suggested by the ability of steroids conjugated to bovine serum albumin to replicate the effect. Experiments were performed to explore the potential role of NMDA receptors in this mechanism. Estradiol (50 pg/ml) and DHT (3 ng/ml) inhibited NMDA stimulated vasopressin release in perifused HNS explants. These results suggest a role of NMDA receptors in the mediation of vasopressin secretion in osmotically stimulated release. Furthermore, estradiol and DHT may exert their inhibitory effect on osmotically stimulated vasopressin release via the NMDA receptor." @default.
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- W2019692020 date "1998-09-01" @default.
- W2019692020 modified "2023-10-15" @default.
- W2019692020 title "<i>N</i>‐Methyl‐d‐Aspartic Acid Stimulation of Vasopressin Release: Role in Osmotic Regulation and Modulation by Gonadal Steriods" @default.
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- W2019692020 doi "https://doi.org/10.1046/j.1365-2826.1998.00257.x" @default.
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