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• W2019692979 abstract "Formaldehyde is a neurotoxic compound that can be endogenously generated in the brain. Because astrocytes play a key role in metabolism and detoxification processes in brain, we have investigated the capacity of these cells to metabolize formaldehyde using primary astrocyte-rich cultures as a model system. Application of formaldehyde to these cultures resulted in the appearance of formate in cells and in a time-, concentration- and temperature-dependent disappearance of formaldehyde from the medium that was accompanied by a matching extracellular accumulation of formate. This formaldehyde-oxidizing capacity of astrocyte cultures is likely to be catalyzed by alcohol dehydrogenase 3 and aldehyde dehydrogenase 2, because the cells of the cultures contain the mRNAs of these formaldehyde-oxidizing enzymes. In addition, exposure to formaldehyde increased both glucose consumption and lactate production by the cells. Both the strong increase in the cellular formate content and the increase in glycolytic flux were only observed after application of formaldehyde to the cells, but not after treatment with exogenous methanol or formate. The accelerated lactate production was not additive to that obtained for azide, a known inhibitor of complex IV of the respiratory chain, and persisted after removal of formaldehyde after a formaldehyde exposure for 1.5 h. These data demonstrate that cultured astrocytes efficiently oxidize formaldehyde to formate, which subsequently enhances glycolytic flux, most likely by inhibition of mitochondrial respiration. © 2012 Wiley Periodicals, Inc." @default.
• W2019692979 created "2016-06-24" @default.
• W2019692979 creator A5005834800 @default.
• W2019692979 creator A5077770397 @default.
• W2019692979 date "2012-01-18" @default.
• W2019692979 modified "2023-10-05" @default.
• W2019692979 title "Formate generated by cellular oxidation of formaldehyde accelerates the glycolytic flux in cultured astrocytes" @default.
• W2019692979 cites W1259543534 @default.
• W2019692979 cites W1485839956 @default.
• W2019692979 cites W1558352148 @default.
• W2019692979 cites W1576215830 @default.
• W2019692979 cites W1579153016 @default.
• W2019692979 cites W1775749144 @default.
• W2019692979 cites W1968418117 @default.
• W2019692979 cites W1969307826 @default.
• W2019692979 cites W1969331218 @default.
• W2019692979 cites W1971722312 @default.
• W2019692979 cites W1972534126 @default.
• W2019692979 cites W1972619806 @default.
• W2019692979 cites W1980624173 @default.
• W2019692979 cites W1984256275 @default.
• W2019692979 cites W1984532830 @default.
• W2019692979 cites W1993149181 @default.
• W2019692979 cites W1993802774 @default.
• W2019692979 cites W1997751808 @default.
• W2019692979 cites W1998329406 @default.
• W2019692979 cites W2000954427 @default.
• W2019692979 cites W2002193250 @default.
• W2019692979 cites W2004357572 @default.
• W2019692979 cites W2008312023 @default.
• W2019692979 cites W2009426085 @default.
• W2019692979 cites W2010861065 @default.
• W2019692979 cites W2012044522 @default.
• W2019692979 cites W2013219946 @default.
• W2019692979 cites W2015527676 @default.
• W2019692979 cites W2015721773 @default.
• W2019692979 cites W2018548861 @default.
• W2019692979 cites W2022260179 @default.
• W2019692979 cites W2027386525 @default.
• W2019692979 cites W2027452448 @default.
• W2019692979 cites W2030843726 @default.
• W2019692979 cites W2031042916 @default.
• W2019692979 cites W2034156554 @default.
• W2019692979 cites W2035512890 @default.
• W2019692979 cites W2036002830 @default.
• W2019692979 cites W2036285113 @default.
• W2019692979 cites W2036443530 @default.
• W2019692979 cites W2036829402 @default.
• W2019692979 cites W2038074753 @default.
• W2019692979 cites W2038863961 @default.
• W2019692979 cites W2040694576 @default.
• W2019692979 cites W2042337953 @default.
• W2019692979 cites W2043074833 @default.
• W2019692979 cites W2050435712 @default.
• W2019692979 cites W2052450238 @default.
• W2019692979 cites W2053756526 @default.
• W2019692979 cites W2055085312 @default.
• W2019692979 cites W2057952010 @default.
• W2019692979 cites W2064127934 @default.
• W2019692979 cites W2064139713 @default.
• W2019692979 cites W2065524010 @default.
• W2019692979 cites W2067055660 @default.
• W2019692979 cites W2073354371 @default.
• W2019692979 cites W2073587565 @default.
• W2019692979 cites W2073744019 @default.
• W2019692979 cites W2077724827 @default.
• W2019692979 cites W2077970611 @default.
• W2019692979 cites W2080847007 @default.
• W2019692979 cites W2082354386 @default.
• W2019692979 cites W2083253912 @default.
• W2019692979 cites W2084712021 @default.
• W2019692979 cites W2086460042 @default.
• W2019692979 cites W2090085965 @default.
• W2019692979 cites W2092495241 @default.
• W2019692979 cites W2095411323 @default.
• W2019692979 cites W2097737969 @default.
• W2019692979 cites W2098086017 @default.
• W2019692979 cites W2100913816 @default.
• W2019692979 cites W2101893734 @default.
• W2019692979 cites W2113402112 @default.
• W2019692979 cites W2145912883 @default.
• W2019692979 cites W2146976930 @default.
• W2019692979 cites W2148611607 @default.
• W2019692979 cites W2149374543 @default.
• W2019692979 cites W2158069974 @default.
• W2019692979 cites W2158681304 @default.
• W2019692979 cites W2163751255 @default.
• W2019692979 cites W2170807667 @default.
• W2019692979 cites W2182822985 @default.
• W2019692979 cites W2222709014 @default.
• W2019692979 cites W2243694838 @default.
• W2019692979 cites W4212766227 @default.
• W2019692979 cites W42922215 @default.
• W2019692979 doi "https://doi.org/10.1002/glia.22292" @default.
• W2019692979 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22258934" @default.
• W2019692979 hasPublicationYear "2012" @default.
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