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- W2019704003 abstract "Summary Background : The role of azathioprine and methotrexate in inducing and maintaining remission in patients with ulcerative colitis is still controversial. Aim : To evaluate the efficacy and tolerability of these two drugs in a series of patients with steroid‐dependent or steroid‐resistant active ulcerative colitis. Methods : Forty‐two patients were treated with a daily dose of azathioprine (2 mg/kg) and, if intolerant or not responding, with methotrexate (12.5 mg/week intramuscularly), and their efficacy was established by clinical, endoscopic and histological examinations at 6 months. Patients achieving clinical remission continued with treatment and were followed up. Results : Of the 42 patients on azathioprine, 10 experienced early side‐effects requiring withdrawal from treatment, 22 (69%) achieved complete remission, six (19%) achieved improvement and four (12%) obtained no substantial benefit. Methotrexate, administered to eight patients intolerant to and two patients resistant to azathioprine, induced complete remission in six patients (60%) and improvement in four (40%). During follow‐up, a larger number of patients on azathioprine relapsed in comparison with patients on methotrexate [16/28 (57%) vs. 2/10 (20%), respectively; P < 0.05]. Only minor side‐effects wereobserved on both treatments. Conclusions : Azathioprine is effective in patients with steroid‐dependent or steroid‐resistant ulcerative colitis. Methotrexate seems to be a good alternative in patients intolerant to or not responding to azathioprine." @default.
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- W2019704003 date "2002-09-19" @default.
- W2019704003 modified "2023-10-18" @default.
- W2019704003 title "Azathioprine or methotrexate in the treatment of patients with steroid-dependent or steroid-resistant ulcerative colitis: results of an open-label study on efficacy and tolerability in inducing and maintaining remission" @default.
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- W2019704003 doi "https://doi.org/10.1046/j.1365-2036.2002.01340.x" @default.
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