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- W2019704267 abstract "Abstract Heterocycle‐containing cyclic peptides are promising scaffolds for the pharmaceutical industry but their chemical synthesis is very challenging. A new universal method has been devised to prepare these compounds by using a set of engineered marine‐derived enzymes and substrates obtained from a family of ribosomally produced and post‐translationally modified peptides called the cyanobactins. The substrate precursor peptide is engineered to have a non‐native protease cleavage site that can be rapidly cleaved. The other enzymes used are heterocyclases that convert Cys or Cys/Ser/Thr into their corresponding azolines. A macrocycle is formed using a macrocyclase enzyme, followed by oxidation of the azolines to azoles with a specific oxidase. The work is exemplified by the production of 17 macrocycles containing 6–9 residues representing 11 out of the 20 canonical amino acids." @default.
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- W2019704267 date "2014-10-21" @default.
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- W2019704267 title "An Efficient Method for the In Vitro Production of Azol(in)e-Based Cyclic Peptides" @default.
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- W2019704267 doi "https://doi.org/10.1002/anie.201408082" @default.
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