Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019707049> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2019707049 endingPage "126" @default.
- W2019707049 startingPage "121" @default.
- W2019707049 abstract "A novel peroxisome proliferator-activated receptor γ (PPARγ) agonist, KR-62980, was determined by liquid–liquid extraction with ethyl acetate and liquid chromatography–tandem mass spectrometry (LC/MS/MS) in rat plasma. In order to evaluate the pharmacokinetics of KR-62980, a reliable, selective and sensitive high-performance liquid chromatographic method with electrospray ionization tandem mass spectrometry was developed for the quantification of KR-62980 in rat plasma. KR-62980 and imipramine (IS) were separated on Hypersil GOLD C18 column with a mixture of acetonitrile–ammonium formate (10 mM) (80:20, v/v) as mobile phase. The ion transitions monitored were m/z 437.2 → 114.2 for KR-62980, m/z 281.3 → 86.1 for imipramine in multiple reaction monitoring (MRM) mode. The percent recoveries of KR-62980 and imipramine were 90.1 and 98.4% from rat plasma, respectively. The linear dynamic range extended from 0.01 to 10 μg/ml with a correlation coefficient (R2) greater than 0.99 and the lower limit of quantification was 0.01 μg/ml. The mean of intra- and inter-assay precisions was 2.1 and 9.3%. The method was validated and successfully applied to the pharmacokinetic study of KR-62980 in rat." @default.
- W2019707049 created "2016-06-24" @default.
- W2019707049 creator A5002548095 @default.
- W2019707049 creator A5014699929 @default.
- W2019707049 creator A5017021374 @default.
- W2019707049 creator A5040250492 @default.
- W2019707049 creator A5043397420 @default.
- W2019707049 creator A5080792622 @default.
- W2019707049 creator A5090407572 @default.
- W2019707049 date "2011-01-01" @default.
- W2019707049 modified "2023-09-23" @default.
- W2019707049 title "Determination of a peroxisome proliferator-activated receptor γ agonist, 1-(trans-methylimino-N-oxy)-6-(2-morpholinoethoxy-3-phenyl-1H-indene-2-carboxylic acid ethyl ester (KR-62980) in rat plasma by liquid chromatography–tandem mass spectrometry" @default.
- W2019707049 cites W1967739345 @default.
- W2019707049 cites W1975798356 @default.
- W2019707049 cites W1979575164 @default.
- W2019707049 cites W1982077060 @default.
- W2019707049 cites W1990147104 @default.
- W2019707049 cites W1993557752 @default.
- W2019707049 cites W2000821877 @default.
- W2019707049 cites W2010353238 @default.
- W2019707049 cites W2024583384 @default.
- W2019707049 cites W2024937953 @default.
- W2019707049 cites W2052884304 @default.
- W2019707049 cites W2054727930 @default.
- W2019707049 cites W2099067020 @default.
- W2019707049 cites W2113432838 @default.
- W2019707049 cites W2117533325 @default.
- W2019707049 cites W2121496639 @default.
- W2019707049 cites W2135173562 @default.
- W2019707049 cites W2167485774 @default.
- W2019707049 doi "https://doi.org/10.1016/j.jpba.2010.07.033" @default.
- W2019707049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20729023" @default.
- W2019707049 hasPublicationYear "2011" @default.
- W2019707049 type Work @default.
- W2019707049 sameAs 2019707049 @default.
- W2019707049 citedByCount "5" @default.
- W2019707049 countsByYear W20197070492012 @default.
- W2019707049 countsByYear W20197070492013 @default.
- W2019707049 countsByYear W20197070492014 @default.
- W2019707049 countsByYear W20197070492023 @default.
- W2019707049 crossrefType "journal-article" @default.
- W2019707049 hasAuthorship W2019707049A5002548095 @default.
- W2019707049 hasAuthorship W2019707049A5014699929 @default.
- W2019707049 hasAuthorship W2019707049A5017021374 @default.
- W2019707049 hasAuthorship W2019707049A5040250492 @default.
- W2019707049 hasAuthorship W2019707049A5043397420 @default.
- W2019707049 hasAuthorship W2019707049A5080792622 @default.
- W2019707049 hasAuthorship W2019707049A5090407572 @default.
- W2019707049 hasConcept C112705442 @default.
- W2019707049 hasConcept C119128265 @default.
- W2019707049 hasConcept C126322002 @default.
- W2019707049 hasConcept C162356407 @default.
- W2019707049 hasConcept C185592680 @default.
- W2019707049 hasConcept C2775986502 @default.
- W2019707049 hasConcept C31827203 @default.
- W2019707049 hasConcept C40684141 @default.
- W2019707049 hasConcept C43617362 @default.
- W2019707049 hasConcept C64489805 @default.
- W2019707049 hasConcept C71043704 @default.
- W2019707049 hasConcept C71924100 @default.
- W2019707049 hasConceptScore W2019707049C112705442 @default.
- W2019707049 hasConceptScore W2019707049C119128265 @default.
- W2019707049 hasConceptScore W2019707049C126322002 @default.
- W2019707049 hasConceptScore W2019707049C162356407 @default.
- W2019707049 hasConceptScore W2019707049C185592680 @default.
- W2019707049 hasConceptScore W2019707049C2775986502 @default.
- W2019707049 hasConceptScore W2019707049C31827203 @default.
- W2019707049 hasConceptScore W2019707049C40684141 @default.
- W2019707049 hasConceptScore W2019707049C43617362 @default.
- W2019707049 hasConceptScore W2019707049C64489805 @default.
- W2019707049 hasConceptScore W2019707049C71043704 @default.
- W2019707049 hasConceptScore W2019707049C71924100 @default.
- W2019707049 hasIssue "1" @default.
- W2019707049 hasLocation W20197070491 @default.
- W2019707049 hasLocation W20197070492 @default.
- W2019707049 hasOpenAccess W2019707049 @default.
- W2019707049 hasPrimaryLocation W20197070491 @default.
- W2019707049 hasRelatedWork W1277187992 @default.
- W2019707049 hasRelatedWork W1998081199 @default.
- W2019707049 hasRelatedWork W2008493283 @default.
- W2019707049 hasRelatedWork W2029274763 @default.
- W2019707049 hasRelatedWork W2062375825 @default.
- W2019707049 hasRelatedWork W2082766191 @default.
- W2019707049 hasRelatedWork W2200897360 @default.
- W2019707049 hasRelatedWork W2391046669 @default.
- W2019707049 hasRelatedWork W2811030537 @default.
- W2019707049 hasRelatedWork W4238213830 @default.
- W2019707049 hasVolume "54" @default.
- W2019707049 isParatext "false" @default.
- W2019707049 isRetracted "false" @default.
- W2019707049 magId "2019707049" @default.
- W2019707049 workType "article" @default.