FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019710414> ?p ?o ?g. }

• W2019710414 endingPage "244" @default.
• W2019710414 startingPage "239" @default.
• W2019710414 abstract "We have recently reported that midazolam, a benzodiazepine receptor agonist that is also a short acting anesthetic and analgesic drug, can produce analgesia and decrease morphine tolerance and dependence in the rat by interacting with the opioidergic system. This study was designed to investigate the chronic effect of midazolam and/or morphine on the levels of dynorphin(1–13) in the pituitary gland, different brain regions, spinal cord and peripheral tissues of the rat. Four sets of animals were used: (I) saline-saline; (II) midazolam (0.03, 0.3 or 3.0 mg/kg, body wt., i.p.)-saline; (III) saline-morphine (10.0 mg/kg, body wt., s.c.); and (IV) midazolam-morphine (0.03, 0.3 or 3.0 mg/kg midazolam+10.0 mg/kg morphine) groups. The first saline or midazolam injection was given i.p. and after 30 min, the second injection of saline or morphine was given s.c. daily for 11 days. Animals were sacrificed on the 11th day, 60 min after the last injection and dynorphin(1–13) was measured in indicated tissues by radioimmunoassay method. The midazolam treated animals showed a significant decrease in dynorphin(1–13) levels in the cortex, cerebellum, cervical region of spinal cord, heart and adrenals, and a significant increase in the hypothalamus, striatum and lumbar region of the spinal cord. The morphine treated animals showed a significant decrease in dynorphin(1–13) levels in the pituitary gland, hypothalamus, hippocampus, striatum, cerebellum, pons, medulla, kidneys, adrenals and spleen, and a significant increase only in the lumbar region of the spinal cord. When both drugs were injected together there was no effect on pituitary gland, kidneys and spleen. These drugs antagonize each other's effect on dynorphin(1–13) in the hypothalamus, striatum, cerebellum, pons, medulla and heart. However, the midazolam-morphine combination significantly increases dynorphin(1–13) levels in the hippocampus, cortex, midbrain, cervical and lumbar regions of the spinal cord, and adrenals. These results suggest the involvement of dynorphin(1–13) in the inhibition of morphine-induced tolerance and dependence by midazolam in the rat. These results may also help us in understanding the intrinsic mechanisms involved in narcotic tolerance and dependence. © 1997 Elsevier Science B.V. All rights reserved." @default.
• W2019710414 created "2016-06-24" @default.
• W2019710414 creator A5007678356 @default.
• W2019710414 creator A5072259478 @default.
• W2019710414 date "1997-04-01" @default.
• W2019710414 modified "2023-10-11" @default.
• W2019710414 title "Effect of chronic treatment with morphine, midazolam and both together on dynorphin(1–13) levels in the rat" @default.
• W2019710414 cites W1969458188 @default.
• W2019710414 cites W1972321263 @default.
• W2019710414 cites W1979116564 @default.
• W2019710414 cites W1986769090 @default.
• W2019710414 cites W1989755623 @default.
• W2019710414 cites W2000161846 @default.
• W2019710414 cites W2010531200 @default.
• W2019710414 cites W2021298703 @default.
• W2019710414 cites W2023676520 @default.
• W2019710414 cites W2029699230 @default.
• W2019710414 cites W2032533982 @default.
• W2019710414 cites W2039340001 @default.
• W2019710414 cites W2044296337 @default.
• W2019710414 cites W2058409135 @default.
• W2019710414 cites W2061298010 @default.
• W2019710414 cites W2072195316 @default.
• W2019710414 cites W2072757678 @default.
• W2019710414 cites W2093410190 @default.
• W2019710414 cites W2093933161 @default.
• W2019710414 cites W2149659974 @default.
• W2019710414 cites W4232534952 @default.
• W2019710414 cites W2012957395 @default.
• W2019710414 doi "https://doi.org/10.1016/s0006-8993(97)00084-x" @default.
• W2019710414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9134981" @default.
• W2019710414 hasPublicationYear "1997" @default.
• W2019710414 type Work @default.
• W2019710414 sameAs 2019710414 @default.
• W2019710414 citedByCount "37" @default.
• W2019710414 countsByYear W20197104142013 @default.
• W2019710414 countsByYear W20197104142016 @default.
• W2019710414 countsByYear W20197104142017 @default.
• W2019710414 countsByYear W20197104142019 @default.
• W2019710414 countsByYear W20197104142021 @default.
• W2019710414 crossrefType "journal-article" @default.
• W2019710414 hasAuthorship W2019710414A5007678356 @default.
• W2019710414 hasAuthorship W2019710414A5072259478 @default.
• W2019710414 hasConcept C126322002 @default.
• W2019710414 hasConcept C134018914 @default.
• W2019710414 hasConcept C151077648 @default.
• W2019710414 hasConcept C170493617 @default.
• W2019710414 hasConcept C185592680 @default.
• W2019710414 hasConcept C2776814716 @default.
• W2019710414 hasConcept C2777003273 @default.
• W2019710414 hasConcept C2777389121 @default.
• W2019710414 hasConcept C2777397205 @default.
• W2019710414 hasConcept C2778000748 @default.
• W2019710414 hasConcept C2781063702 @default.
• W2019710414 hasConcept C42219234 @default.
• W2019710414 hasConcept C71924100 @default.
• W2019710414 hasConcept C88016717 @default.
• W2019710414 hasConceptScore W2019710414C126322002 @default.
• W2019710414 hasConceptScore W2019710414C134018914 @default.
• W2019710414 hasConceptScore W2019710414C151077648 @default.
• W2019710414 hasConceptScore W2019710414C170493617 @default.
• W2019710414 hasConceptScore W2019710414C185592680 @default.
• W2019710414 hasConceptScore W2019710414C2776814716 @default.
• W2019710414 hasConceptScore W2019710414C2777003273 @default.
• W2019710414 hasConceptScore W2019710414C2777389121 @default.
• W2019710414 hasConceptScore W2019710414C2777397205 @default.
• W2019710414 hasConceptScore W2019710414C2778000748 @default.
• W2019710414 hasConceptScore W2019710414C2781063702 @default.
• W2019710414 hasConceptScore W2019710414C42219234 @default.
• W2019710414 hasConceptScore W2019710414C71924100 @default.
• W2019710414 hasConceptScore W2019710414C88016717 @default.
• W2019710414 hasIssue "1-2" @default.
• W2019710414 hasLocation W20197104141 @default.
• W2019710414 hasLocation W20197104142 @default.
• W2019710414 hasOpenAccess W2019710414 @default.
• W2019710414 hasPrimaryLocation W20197104141 @default.
• W2019710414 hasRelatedWork W1976466188 @default.
• W2019710414 hasRelatedWork W1987801079 @default.
• W2019710414 hasRelatedWork W2014608892 @default.
• W2019710414 hasRelatedWork W2032284020 @default.
• W2019710414 hasRelatedWork W2071531876 @default.
• W2019710414 hasRelatedWork W2075201109 @default.
• W2019710414 hasRelatedWork W2255441518 @default.
• W2019710414 hasRelatedWork W2375378931 @default.
• W2019710414 hasRelatedWork W3030170170 @default.
• W2019710414 hasRelatedWork W953704126 @default.
• W2019710414 hasVolume "754" @default.
• W2019710414 isParatext "false" @default.
• W2019710414 isRetracted "false" @default.
• W2019710414 magId "2019710414" @default.
• W2019710414 workType "article" @default.