FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019716616> ?p ?o ?g. }

• W2019716616 abstract "Many attempts have been made at developing biomarkers for stroke. Although successful to some degree,1–3 none have been sufficiently robust to be used in clinical practice. Thus, there is still a great need for more in-depth studies of the biology of human stroke to understand its pathogenesis better. This should make it possible to develop blood tests for stroke and transient ischemic attacks (TIAs) to guide treatment and ultimately improve outcomes.The traditional approach to develop stroke biomarkers has been to select candidate markers based on known pathobiology. The majority of markers that have been evaluated are proteins that are measured in patients at various times before or after stroke. The rationale for this approach is that brain injury releases molecules into blood that can be measured as evidence of brain injury; or that other cells and organs release molecules that either cause or contribute to a stroke, or are a response to the stroke. These approaches have been handicapped because they require a guess at the most reliable biomarker.Our group took a different approach to the problem by assessing the immune system after stroke.4,5 The rationale for this approach is shown in Figure 1. The expression of genes in leukocytes is influenced by many factors associated with ischemic stroke. Leukocytes interact with blood clots, platelets, atherosclerotic plaque, and injured brain endothelial cells via adhesion molecules.5 In addition, leukocytes detect circulating cytokines, chemokines, and hormones. Each has the potential to modulate RNA expression in leukocytes.Figure 1. Schematic of interactions between circulating leukocytes and factors involved in ischemic stroke, including blood clots, platelets, atherosclerotic plaque, and damaged endothelial cells. Each factor can influence expression of leukocyte RNA. This figure is reproduced from an article by Sharp et al.5To provide proof-of-principle that …" @default.
• W2019716616 created "2016-06-24" @default.
• W2019716616 creator A5021502220 @default.
• W2019716616 creator A5088465643 @default.
• W2019716616 date "2013-05-24" @default.
• W2019716616 modified "2023-09-28" @default.
• W2019716616 title "Whole Genome Expression of Cellular Response to Stroke" @default.
• W2019716616 cites W1966610668 @default.
• W2019716616 cites W1971102747 @default.
• W2019716616 cites W1988902477 @default.
• W2019716616 cites W2007489644 @default.
• W2019716616 cites W2038198389 @default.
• W2019716616 cites W2041981464 @default.
• W2019716616 cites W2042359907 @default.
• W2019716616 cites W2044647551 @default.
• W2019716616 cites W2049373941 @default.
• W2019716616 cites W2052723568 @default.
• W2019716616 cites W2064996657 @default.
• W2019716616 cites W2081341956 @default.
• W2019716616 cites W2099744219 @default.
• W2019716616 cites W2106301720 @default.
• W2019716616 cites W2116146198 @default.
• W2019716616 cites W2117071256 @default.
• W2019716616 cites W2128049611 @default.
• W2019716616 cites W2132190410 @default.
• W2019716616 cites W2161758522 @default.
• W2019716616 cites W2169952667 @default.
• W2019716616 cites W2411319754 @default.
• W2019716616 doi "https://doi.org/10.1161/strokeaha.112.679357" @default.
• W2019716616 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3888808" @default.
• W2019716616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23709718" @default.
• W2019716616 hasPublicationYear "2013" @default.
• W2019716616 type Work @default.
• W2019716616 sameAs 2019716616 @default.
• W2019716616 citedByCount "17" @default.
• W2019716616 countsByYear W20197166162013 @default.
• W2019716616 countsByYear W20197166162014 @default.
• W2019716616 countsByYear W20197166162015 @default.
• W2019716616 countsByYear W20197166162016 @default.
• W2019716616 countsByYear W20197166162017 @default.
• W2019716616 countsByYear W20197166162018 @default.
• W2019716616 countsByYear W20197166162019 @default.
• W2019716616 crossrefType "journal-article" @default.
• W2019716616 hasAuthorship W2019716616A5021502220 @default.
• W2019716616 hasAuthorship W2019716616A5088465643 @default.
• W2019716616 hasBestOaLocation W20197166161 @default.
• W2019716616 hasConcept C127413603 @default.
• W2019716616 hasConcept C13373296 @default.
• W2019716616 hasConcept C169760540 @default.
• W2019716616 hasConcept C203014093 @default.
• W2019716616 hasConcept C2780640218 @default.
• W2019716616 hasConcept C2780645631 @default.
• W2019716616 hasConcept C2780942790 @default.
• W2019716616 hasConcept C2781197716 @default.
• W2019716616 hasConcept C55493867 @default.
• W2019716616 hasConcept C60644358 @default.
• W2019716616 hasConcept C71924100 @default.
• W2019716616 hasConcept C78519656 @default.
• W2019716616 hasConcept C86803240 @default.
• W2019716616 hasConcept C8891405 @default.
• W2019716616 hasConceptScore W2019716616C127413603 @default.
• W2019716616 hasConceptScore W2019716616C13373296 @default.
• W2019716616 hasConceptScore W2019716616C169760540 @default.
• W2019716616 hasConceptScore W2019716616C203014093 @default.
• W2019716616 hasConceptScore W2019716616C2780640218 @default.
• W2019716616 hasConceptScore W2019716616C2780645631 @default.
• W2019716616 hasConceptScore W2019716616C2780942790 @default.
• W2019716616 hasConceptScore W2019716616C2781197716 @default.
• W2019716616 hasConceptScore W2019716616C55493867 @default.
• W2019716616 hasConceptScore W2019716616C60644358 @default.
• W2019716616 hasConceptScore W2019716616C71924100 @default.
• W2019716616 hasConceptScore W2019716616C78519656 @default.
• W2019716616 hasConceptScore W2019716616C86803240 @default.
• W2019716616 hasConceptScore W2019716616C8891405 @default.
• W2019716616 hasLocation W20197166161 @default.
• W2019716616 hasLocation W20197166162 @default.
• W2019716616 hasLocation W20197166163 @default.
• W2019716616 hasLocation W20197166164 @default.
• W2019716616 hasOpenAccess W2019716616 @default.
• W2019716616 hasPrimaryLocation W20197166161 @default.
• W2019716616 hasRelatedWork W1967978968 @default.
• W2019716616 hasRelatedWork W1996490160 @default.
• W2019716616 hasRelatedWork W2041981464 @default.
• W2019716616 hasRelatedWork W2044647551 @default.
• W2019716616 hasRelatedWork W2046869253 @default.
• W2019716616 hasRelatedWork W2049373941 @default.
• W2019716616 hasRelatedWork W2099744219 @default.
• W2019716616 hasRelatedWork W2116146198 @default.
• W2019716616 hasRelatedWork W2118200665 @default.
• W2019716616 hasRelatedWork W2285219937 @default.
• W2019716616 hasRelatedWork W2321577496 @default.
• W2019716616 hasRelatedWork W2557356722 @default.
• W2019716616 hasRelatedWork W2594241500 @default.
• W2019716616 hasRelatedWork W2763569355 @default.
• W2019716616 hasRelatedWork W2986246817 @default.
• W2019716616 hasRelatedWork W3011780979 @default.
• W2019716616 hasRelatedWork W3086236876 @default.
• W2019716616 hasRelatedWork W3089816867 @default.
• W2019716616 hasRelatedWork W3092560172 @default.
• W2019716616 hasRelatedWork W3128361695 @default.

• next