Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019717013> ?p ?o ?g. }
- W2019717013 endingPage "140" @default.
- W2019717013 startingPage "124" @default.
- W2019717013 abstract "Timely removal of oxidatively damaged proteins is critical for cells exposed to oxidative stresses; however, cellular mechanism for clearing oxidized proteins is not clear. Our study reveals a novel type of protein modification that may play a role in targeting oxidized proteins and remove them. In this process, DSS1 (deleted in split hand/split foot 1), an evolutionally conserved small protein, is conjugated to proteins induced by oxidative stresses in vitro and in vivo, implying oxidized proteins are DSS1 clients. A subsequent ubiquitination targeting DSS1-protein adducts has been observed, suggesting the client proteins are degraded through the ubiquitin-proteasome pathway. The DSS1 attachment to its clients is evidenced to be an enzymatic process modulated by an unidentified ATPase. We name this novel protein modification as DSSylation, in which DSS1 plays as a modifier, whose attachment may render target proteins a signature leading to their subsequent ubiquitination, thereby recruits proteasome to degrade them." @default.
- W2019717013 created "2016-06-24" @default.
- W2019717013 creator A5003236713 @default.
- W2019717013 creator A5029143160 @default.
- W2019717013 creator A5031887553 @default.
- W2019717013 creator A5035230648 @default.
- W2019717013 creator A5042688349 @default.
- W2019717013 creator A5042776973 @default.
- W2019717013 creator A5043349619 @default.
- W2019717013 creator A5052350642 @default.
- W2019717013 creator A5055714044 @default.
- W2019717013 creator A5064970788 @default.
- W2019717013 creator A5065828916 @default.
- W2019717013 creator A5067365392 @default.
- W2019717013 creator A5076209858 @default.
- W2019717013 creator A5081988869 @default.
- W2019717013 date "2014-02-01" @default.
- W2019717013 modified "2023-09-25" @default.
- W2019717013 title "DSSylation, a novel protein modification targets proteins induced by oxidative stress, and facilitates their degradation in cells" @default.
- W2019717013 cites W1485416082 @default.
- W2019717013 cites W1503901149 @default.
- W2019717013 cites W1534171724 @default.
- W2019717013 cites W1597643123 @default.
- W2019717013 cites W1936380547 @default.
- W2019717013 cites W1949298472 @default.
- W2019717013 cites W1961774825 @default.
- W2019717013 cites W1968229731 @default.
- W2019717013 cites W1968704764 @default.
- W2019717013 cites W1969505359 @default.
- W2019717013 cites W1980064429 @default.
- W2019717013 cites W1980745735 @default.
- W2019717013 cites W1981465641 @default.
- W2019717013 cites W1985031521 @default.
- W2019717013 cites W1985591678 @default.
- W2019717013 cites W1987206830 @default.
- W2019717013 cites W1988746802 @default.
- W2019717013 cites W2000292506 @default.
- W2019717013 cites W2004283265 @default.
- W2019717013 cites W2007157911 @default.
- W2019717013 cites W2008128102 @default.
- W2019717013 cites W2011272179 @default.
- W2019717013 cites W2012296420 @default.
- W2019717013 cites W2013429682 @default.
- W2019717013 cites W2015881243 @default.
- W2019717013 cites W2019496322 @default.
- W2019717013 cites W2020120461 @default.
- W2019717013 cites W2021919397 @default.
- W2019717013 cites W2025106485 @default.
- W2019717013 cites W2032996948 @default.
- W2019717013 cites W2033839927 @default.
- W2019717013 cites W2038878016 @default.
- W2019717013 cites W2041973951 @default.
- W2019717013 cites W2044695362 @default.
- W2019717013 cites W2045144602 @default.
- W2019717013 cites W2047937380 @default.
- W2019717013 cites W2047983287 @default.
- W2019717013 cites W2048897966 @default.
- W2019717013 cites W2048966030 @default.
- W2019717013 cites W2049569756 @default.
- W2019717013 cites W2053450572 @default.
- W2019717013 cites W2056867819 @default.
- W2019717013 cites W2058302603 @default.
- W2019717013 cites W2064380972 @default.
- W2019717013 cites W2069309708 @default.
- W2019717013 cites W2075862048 @default.
- W2019717013 cites W2076834744 @default.
- W2019717013 cites W2084034209 @default.
- W2019717013 cites W2093525687 @default.
- W2019717013 cites W2103573935 @default.
- W2019717013 cites W2111250240 @default.
- W2019717013 cites W2115414474 @default.
- W2019717013 cites W2120772351 @default.
- W2019717013 cites W2123781000 @default.
- W2019717013 cites W2124098523 @default.
- W2019717013 cites W2132270233 @default.
- W2019717013 cites W2138057005 @default.
- W2019717013 cites W2141819645 @default.
- W2019717013 cites W2143500687 @default.
- W2019717013 cites W2147993424 @default.
- W2019717013 cites W2150418491 @default.
- W2019717013 cites W2162695817 @default.
- W2019717013 cites W2166987747 @default.
- W2019717013 cites W2170773702 @default.
- W2019717013 cites W2171108478 @default.
- W2019717013 cites W2177092266 @default.
- W2019717013 doi "https://doi.org/10.1007/s13238-013-0018-8" @default.
- W2019717013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3956975" @default.
- W2019717013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24515614" @default.
- W2019717013 hasPublicationYear "2014" @default.
- W2019717013 type Work @default.
- W2019717013 sameAs 2019717013 @default.
- W2019717013 citedByCount "9" @default.
- W2019717013 countsByYear W20197170132014 @default.
- W2019717013 countsByYear W20197170132018 @default.
- W2019717013 countsByYear W20197170132020 @default.
- W2019717013 countsByYear W20197170132021 @default.
- W2019717013 countsByYear W20197170132023 @default.
- W2019717013 crossrefType "journal-article" @default.