Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019718832> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W2019718832 abstract "Inhibin-alpha subunit (Inh-alpha) gene expression is important for granulosa cell (GC) differentiation and prevention of ovarian tumorigenesis. Studies on Inh-alpha regulation have implicated activin and insulin-like growth factor-I (IGF-I) in the mechanisms of expression. Here we present evidence that endogenously produced IGF-I plays an obligatory role in activin-induced Inh-alpha production. Primary cultures of rat GC were incubated with increasing concentrations of various regulatory molecules, and the levels of Inh-alpha protein and its mRNA were measured in conditioned medium and cells, respectively. Recombinant activin A stimulated Inh-alpha expression, and the effects were dose- and time-dependent. The receptor tyrosine kinase inhibitor tyrphostin A23 caused a dose-dependent inhibition of activin-dependent Inh-alpha expression, whereas the inactive isomer, A63, had no effect. The stimulatory effect of activin was also blocked in a dose-dependent manner by added IGF binding protein-4 or -5, and the effects were reversed by IGF-I. Moreover, increasing concentrations of an anti-IGF-I antibody had a similar inhibitory effect on activin-stimulated Inh-alpha expression. Collectively, these results suggest, for the first time, that endogenously produced IGF-I is required for activin stimulation of Inh-alpha expression in cultured rat GC." @default.
- W2019718832 created "2016-06-24" @default.
- W2019718832 creator A5006238723 @default.
- W2019718832 creator A5025124462 @default.
- W2019718832 creator A5040447695 @default.
- W2019718832 creator A5056975051 @default.
- W2019718832 creator A5079927459 @default.
- W2019718832 date "1998-03-01" @default.
- W2019718832 modified "2023-09-23" @default.
- W2019718832 title "Activin-Induced Inhibin α-Subunit Production by Rat Granulosa Cells Requires Endogenous Insulin-Like Growth Factor-I1" @default.
- W2019718832 doi "https://doi.org/10.1095/biolreprod58.3.712" @default.
- W2019718832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9510958" @default.
- W2019718832 hasPublicationYear "1998" @default.
- W2019718832 type Work @default.
- W2019718832 sameAs 2019718832 @default.
- W2019718832 citedByCount "12" @default.
- W2019718832 crossrefType "journal-article" @default.
- W2019718832 hasAuthorship W2019718832A5006238723 @default.
- W2019718832 hasAuthorship W2019718832A5025124462 @default.
- W2019718832 hasAuthorship W2019718832A5040447695 @default.
- W2019718832 hasAuthorship W2019718832A5056975051 @default.
- W2019718832 hasAuthorship W2019718832A5079927459 @default.
- W2019718832 hasBestOaLocation W20197188321 @default.
- W2019718832 hasConcept C104292427 @default.
- W2019718832 hasConcept C104317684 @default.
- W2019718832 hasConcept C111001777 @default.
- W2019718832 hasConcept C118131993 @default.
- W2019718832 hasConcept C126322002 @default.
- W2019718832 hasConcept C134018914 @default.
- W2019718832 hasConcept C159110408 @default.
- W2019718832 hasConcept C170493617 @default.
- W2019718832 hasConcept C22517002 @default.
- W2019718832 hasConcept C2775944032 @default.
- W2019718832 hasConcept C2775960820 @default.
- W2019718832 hasConcept C2778649528 @default.
- W2019718832 hasConcept C2780689927 @default.
- W2019718832 hasConcept C38643226 @default.
- W2019718832 hasConcept C49453240 @default.
- W2019718832 hasConcept C55493867 @default.
- W2019718832 hasConcept C64943373 @default.
- W2019718832 hasConcept C71924100 @default.
- W2019718832 hasConcept C83730767 @default.
- W2019718832 hasConcept C86803240 @default.
- W2019718832 hasConceptScore W2019718832C104292427 @default.
- W2019718832 hasConceptScore W2019718832C104317684 @default.
- W2019718832 hasConceptScore W2019718832C111001777 @default.
- W2019718832 hasConceptScore W2019718832C118131993 @default.
- W2019718832 hasConceptScore W2019718832C126322002 @default.
- W2019718832 hasConceptScore W2019718832C134018914 @default.
- W2019718832 hasConceptScore W2019718832C159110408 @default.
- W2019718832 hasConceptScore W2019718832C170493617 @default.
- W2019718832 hasConceptScore W2019718832C22517002 @default.
- W2019718832 hasConceptScore W2019718832C2775944032 @default.
- W2019718832 hasConceptScore W2019718832C2775960820 @default.
- W2019718832 hasConceptScore W2019718832C2778649528 @default.
- W2019718832 hasConceptScore W2019718832C2780689927 @default.
- W2019718832 hasConceptScore W2019718832C38643226 @default.
- W2019718832 hasConceptScore W2019718832C49453240 @default.
- W2019718832 hasConceptScore W2019718832C55493867 @default.
- W2019718832 hasConceptScore W2019718832C64943373 @default.
- W2019718832 hasConceptScore W2019718832C71924100 @default.
- W2019718832 hasConceptScore W2019718832C83730767 @default.
- W2019718832 hasConceptScore W2019718832C86803240 @default.
- W2019718832 hasLocation W20197188321 @default.
- W2019718832 hasLocation W20197188322 @default.
- W2019718832 hasOpenAccess W2019718832 @default.
- W2019718832 hasPrimaryLocation W20197188321 @default.
- W2019718832 hasRelatedWork W1977963838 @default.
- W2019718832 hasRelatedWork W1982317451 @default.
- W2019718832 hasRelatedWork W1989210846 @default.
- W2019718832 hasRelatedWork W1995347296 @default.
- W2019718832 hasRelatedWork W1997395577 @default.
- W2019718832 hasRelatedWork W1997889278 @default.
- W2019718832 hasRelatedWork W1999096385 @default.
- W2019718832 hasRelatedWork W2002281751 @default.
- W2019718832 hasRelatedWork W2126532023 @default.
- W2019718832 hasRelatedWork W2156844778 @default.
- W2019718832 isParatext "false" @default.
- W2019718832 isRetracted "false" @default.
- W2019718832 magId "2019718832" @default.
- W2019718832 workType "article" @default.