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- W2019741729 abstract "The integrase protein of bacteriophage λ (Int) catalyzes site-specific recombination between λ phage and Escherichia coli genomes. Int is a tyrosine recombinase that binds to DNA core sites via a C-terminal catalytic domain and to a collection of arm DNA sites, distant from the site of recombination, via its N-terminal domain. The arm sites, in conjunction with accessory DNA-bending proteins, provide a means of regulating the efficiency and directionality of Int-catalyzed recombination. Recent crystal structures of λ Int tetramers bound to synaptic and Holliday junction intermediates, together with new biochemical data, suggest a mechanism for the allosteric control of the recombination reaction through arm DNA binding interactions." @default.
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- W2019741729 date "2006-02-01" @default.
- W2019741729 modified "2023-09-29" @default.
- W2019741729 title "DNA arms do the legwork to ensure the directionality of λ site-specific recombination" @default.
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- W2019741729 doi "https://doi.org/10.1016/j.sbi.2005.12.003" @default.
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