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• W2019746827 abstract "Significance Cellular and molecular mechanisms underlying the assembly of nodes of Ranvier of myelinated axons in the CNS are still only partly understood. Our study shows the influence of intrinsic cues and glial extrinsic factors for nodal protein clustering before myelination on specific hippocampal neuronal subpopulations and extends to electrophysiological understandings and in vivo relevance. Although conduction velocity along axons has long been thought to mostly rely on the insulating properties of myelin, we here show that nodal protein aggregation can increase this speed in the absence of such insulation. These results highlight the role of nodal clusters per se on conduction velocity by uncoupling it from myelination." @default.
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• W2019746827 date "2015-01-05" @default.
• W2019746827 modified "2023-09-30" @default.
• W2019746827 title "Acceleration of conduction velocity linked to clustering of nodal components precedes myelination" @default.
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• W2019746827 doi "https://doi.org/10.1073/pnas.1419099112" @default.
• W2019746827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4311839" @default.
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