FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019751406> ?p ?o ?g. }

• W2019751406 abstract "Vertebrates are constantly exposed to pathogens, and the adaptive immunity has most likely evolved to control and clear such infectious agents. CD4(+) T cells are the major players in the adaptive immune response to pathogens. Following recognition of pathogen-derived antigens naïve CD4(+) T cells differentiate into effectors which then control pathogen replication either directly by killing pathogen-infected cells or by assisting with generation of cytotoxic T lymphocytes (CTLs) or pathogen-specific antibodies. Pathogen-specific effector CD4(+) T cells are highly heterogeneous in terms of cytokines they produce. Three major subtypes of effector CD4(+) T cells have been identified: T-helper 1 (Th1) cells producing IFN-γ and TNF-α, Th2 cells producing IL-4 and IL-10, and Th17 cells producing IL-17. How this heterogeneity is maintained and what regulates changes in effector T cell composition during chronic infections remains poorly understood. In this review we discuss recent advances in our understanding of CD4(+) T cell differentiation in response to microbial infections. We propose that a change in the phenotype of pathogen-specific effector CD4(+) T cells during chronic infections, for example, from Th1 to Th2 response as observed in Mycobactrium avium ssp. paratuberculosis (MAP) infection of ruminants, can be achieved by conversion of T cells from one effector subset to another (cellular plasticity) or due to differences in kinetics (differentiation, proliferation, death) of different effector T cell subsets (population plasticity). We also shortly review mathematical models aimed at describing CD4(+) T cell differentiation and outline areas for future experimental and theoretical research." @default.
• W2019751406 created "2016-06-24" @default.
• W2019751406 creator A5009256033 @default.
• W2019751406 creator A5028479958 @default.
• W2019751406 creator A5051500900 @default.
• W2019751406 creator A5053252368 @default.
• W2019751406 date "2013-01-01" @default.
• W2019751406 modified "2023-10-03" @default.
• W2019751406 title "Cellular and population plasticity of helper CD4+ T cell responses" @default.
• W2019751406 cites W1516875724 @default.
• W2019751406 cites W1546749202 @default.
• W2019751406 cites W1591146540 @default.
• W2019751406 cites W1605146278 @default.
• W2019751406 cites W1702064063 @default.
• W2019751406 cites W1777738032 @default.
• W2019751406 cites W179285875 @default.
• W2019751406 cites W1845629018 @default.
• W2019751406 cites W1942668068 @default.
• W2019751406 cites W1966353262 @default.
• W2019751406 cites W1973548013 @default.
• W2019751406 cites W1979514172 @default.
• W2019751406 cites W1979782245 @default.
• W2019751406 cites W1981941131 @default.
• W2019751406 cites W1995519355 @default.
• W2019751406 cites W2001392251 @default.
• W2019751406 cites W2002987322 @default.
• W2019751406 cites W2006338259 @default.
• W2019751406 cites W2010293066 @default.
• W2019751406 cites W2011754426 @default.
• W2019751406 cites W2011882192 @default.
• W2019751406 cites W2013495037 @default.
• W2019751406 cites W2014392153 @default.
• W2019751406 cites W2019951158 @default.
• W2019751406 cites W2020122130 @default.
• W2019751406 cites W2020304403 @default.
• W2019751406 cites W2023809975 @default.
• W2019751406 cites W2024524568 @default.
• W2019751406 cites W2026690665 @default.
• W2019751406 cites W2027964903 @default.
• W2019751406 cites W2029819700 @default.
• W2019751406 cites W2033539827 @default.
• W2019751406 cites W2041320451 @default.
• W2019751406 cites W2041924570 @default.
• W2019751406 cites W2042342001 @default.
• W2019751406 cites W2042784167 @default.
• W2019751406 cites W2043776488 @default.
• W2019751406 cites W2044163622 @default.
• W2019751406 cites W2049976069 @default.
• W2019751406 cites W2052873213 @default.
• W2019751406 cites W2052998574 @default.
• W2019751406 cites W2054344840 @default.
• W2019751406 cites W2064304633 @default.
• W2019751406 cites W2065638217 @default.
• W2019751406 cites W2066738380 @default.
• W2019751406 cites W2066931725 @default.
• W2019751406 cites W2068046103 @default.
• W2019751406 cites W2068122289 @default.
• W2019751406 cites W2068253536 @default.
• W2019751406 cites W2070791475 @default.
• W2019751406 cites W2072492970 @default.
• W2019751406 cites W2074067501 @default.
• W2019751406 cites W2075097313 @default.
• W2019751406 cites W2079460879 @default.
• W2019751406 cites W2080721009 @default.
• W2019751406 cites W2081360252 @default.
• W2019751406 cites W2082615963 @default.
• W2019751406 cites W2085540206 @default.
• W2019751406 cites W2087000674 @default.
• W2019751406 cites W2088121552 @default.
• W2019751406 cites W2090727611 @default.
• W2019751406 cites W2091451666 @default.
• W2019751406 cites W2091570353 @default.
• W2019751406 cites W2092345398 @default.
• W2019751406 cites W2095094617 @default.
• W2019751406 cites W2099899075 @default.
• W2019751406 cites W2099918076 @default.
• W2019751406 cites W2107235439 @default.
• W2019751406 cites W2107307935 @default.
• W2019751406 cites W2109383738 @default.
• W2019751406 cites W2110491264 @default.
• W2019751406 cites W2114355189 @default.
• W2019751406 cites W2117449032 @default.
• W2019751406 cites W2123642439 @default.
• W2019751406 cites W2130253814 @default.
• W2019751406 cites W2134342374 @default.
• W2019751406 cites W2141649011 @default.
• W2019751406 cites W2142017607 @default.
• W2019751406 cites W2144185816 @default.
• W2019751406 cites W2145735900 @default.
• W2019751406 cites W2150492554 @default.
• W2019751406 cites W2155500723 @default.
• W2019751406 cites W2155779547 @default.
• W2019751406 cites W2158882856 @default.
• W2019751406 cites W2160196028 @default.
• W2019751406 cites W2162819001 @default.
• W2019751406 cites W2165975386 @default.
• W2019751406 cites W2166013628 @default.
• W2019751406 cites W2167288071 @default.
• W2019751406 cites W2172466148 @default.
• W2019751406 cites W2414393341 @default.

• next