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- W2019755330 endingPage "390" @default.
- W2019755330 startingPage "377" @default.
- W2019755330 abstract "Buprenorphine, a long-acting opioid with both agonist and antagonist properties, binds to mu-opioid (OP(3)), kappa-opioid (OP(2)), delta-opioid (OP(1)), and nociceptin (ORL-1) receptors. Its actions at these receptors have not been completely characterized, although buprenorphine is generally regarded as a mu-opioid receptor partial agonist and a kappa-opioid receptor antagonist. Its pharmacology is further complicated by an active metabolite, norbuprenorphine. Although buprenorphine can be used as an analgesic agent, it is of greater importance in the treatment of opioid abuse. Because of its partial agonist activity at mu-opioid receptors and its long half-life, buprenorphine has proven to be an excellent alternative to methadone for either maintenance therapy or detoxification of the opioid addict. Although buprenorphine may ultimately prove to be superior to methadone in the maintenance of the pregnant addict, its effects on the developing fetus must be carefully evaluated." @default.
- W2019755330 created "2016-06-24" @default.
- W2019755330 creator A5005304236 @default.
- W2019755330 date "2006-06-07" @default.
- W2019755330 modified "2023-10-14" @default.
- W2019755330 title "Buprenorphine: An Analgesic with an Expanding Role in the Treatment of Opioid Addiction" @default.
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