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• W2019756871 startingPage "218" @default.
• W2019756871 abstract "In leeches, two pairs of reciprocally inhibitory heart interneurons that form the core oscillators of the pattern-generating network for heartbeat possess both high- and low-threshold (HVA and LVA) Ca channels. LVA Ca current has two kinetically distinct components (one rapidly activating/inactivating, I CaF , and another slowly activating/inactivating, I CaS ) that mediate graded transmission, generate plateau potentials driving burst formation, and modulate spike-mediated transmission between heart interneurons. Here we used different stimulating protocols and inorganic Ca channel blockers to separate the effects of I CaF and I CaS on graded synaptic transmission and determine their interaction and relative efficacy. Ca 2+ entering by I CaF channels is more efficacious in mediating release than that entering by I CaS channels. The rate of Ca 2+ entry by LVA Ca channels appears to be as critical as the amount of delivered Ca 2+ for synaptic transmission. LVA Ca currents and associated graded transmission were selectively blocked by 1 mM Ni 2+ , leaving spike-mediated transmission unaffected. Nevertheless, 1 mM Ni 2+ affected homosynaptic enhancement of spike-mediated transmission that depends on background Ca 2+ provided by LVA Ca channels. Ca 2+ provided by both I CaF and I CaS depletes a common pool of readily releasable synaptic vesicles. The balance between availability of vesicles and Ca 2+ concentration and its time course determine the strength of inhibitory transmission between heart interneurons. We argue that Ca 2+ from multichannel domains arising from I CaF channels, clustered near but not directly associated with the release trigger, and Ca 2+ radially diffusing from generally distributed I CaS channels interact at common release sites to mediate graded transmission." @default.
• W2019756871 created "2016-06-24" @default.
• W2019756871 creator A5042846824 @default.
• W2019756871 creator A5054058033 @default.
• W2019756871 date "2006-07-01" @default.
• W2019756871 modified "2023-09-29" @default.
• W2019756871 title "Graded Inhibitory Synaptic Transmission Between Leech Interneurons: Assessing the Roles of Two Kinetically Distinct Low-Threshold Ca Currents" @default.
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• W2019756871 doi "https://doi.org/10.1152/jn.01093.2005" @default.
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