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- W2019756974 abstract "Chronic systolic heart failure (CHF) is a cardinal clinical manifestation of Chagas cardiomyopathy. It affects 2–4% of a general, unselected community-based population, up to 76% of patients referred to a tertiary referral center [ [1] Bestetti R.B. Theodoropoulos T.A.D. Cardinalli-Neto A. Cury P.M. Treatment of chronic systolic heart failure secondary to Chagas' heart disease in the current era of heart failure therapy. Am Heart J. 2008; 156: 422-430 Abstract Full Text Full Text PDF PubMed Scopus (36) Google Scholar ], and is the leading cause of CHF in areas where the disease is endemic [ [2] Bocchi E.A. Braga F.G. Ferreira S.M. et al. III Brazilian guidelines on chronic heart failure. Arq Bras Cardiol. 2009; 93: 3-70 PubMed Google Scholar ]. The underlying myocardial lesions in patients with Chagas cardiomyopathy with CHF is the association of confluent foci of fibrosis and disseminated mononuclear cell infiltrate [ [3] Rossi M.A. Ramos S.G. Bestetti R.B. Chagas' heart disease: clinical–pathological correlation. Front Biosci. 2003; 8: e94-e109 Crossref PubMed Scopus (41) Google Scholar ], which accelerates the remodeling process and makes the prognosis worse than that observed in patients with non-Chagas disease CHF [ 4 Bertolino N.D. Villafanha D.F. Cardinalli-Neto A. et al. Prognostic impact of Chagas' disease in patients awaiting heart transplantation. J Heart Lung Transplant. 2010; 29: 449-453 Abstract Full Text Full Text PDF PubMed Scopus (38) Google Scholar , 5 Freitas H.F.G. Chizzola P.R. Paes A.T. Lima A.C. Mansur A.J. Risk stratification in a Brazilian hospital-based cohort of 1220 outpatients with heart failure: role of Chagas' heart disease. Int J Cardiol. 2005; 102: 239-247 Abstract Full Text Full Text PDF PubMed Scopus (151) Google Scholar ]." @default.
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- W2019756974 date "2011-10-01" @default.
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- W2019756974 title "Chronic renal impairment in patients with Chagas cardiomyopathy with chronic systolic heart failure: Prevalence and prognostic significance" @default.
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- W2019756974 doi "https://doi.org/10.1016/j.ijcard.2011.07.060" @default.
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