FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019757429> ?p ?o ?g. }

• W2019757429 endingPage "184" @default.
• W2019757429 startingPage "177" @default.
• W2019757429 abstract "Cholecystokinin (CCK) is a gut hormone that regulates pancreatic endocrine functions via CCK(A) receptors. CCK(4) (Trp-Met-Asp-Phe-NH(2)) has an insulinotropic effect, but is 1,000-fold less potent than CCK(8) in rodents. The in vitro potencies with respect to binding, the biological effects and the selectivity of newly synthesized CCK(4) analogs constructed by computer modelling experiments were investigated in vitro in rat pancreas and brain, INS-1 cells, and guinea pig ileum. Exchanging various amino acids, e.g. Met by either Pro or Nle, and modifying Phe by adding various substituents in different positions led to compounds which were more effective as insulin secretagogues than CCK(4) itself and even show insulinotropic effects comparable with those of CCK(8) (e. g. compounds M1 and M2 being substituted at Phe). Some compounds which possess electron withdrawing groups on the C-terminal Phe and possess a Pro instead of a Met were especially effective. The CCK(A) receptor antagonist L-364,718, but not by the CCK(B) receptor antagonist L-365,260, inhibited the insulinotropic effects. The synthetic CCK(4) compounds were not selective for the endocrine pancreas: e.g. M1 and M2 had binding activity with respect to rat brain homogenates but no activity with respect to contraction of the guinea pig ileum. The data indicate that some of the newly synthesized CCK tetrapeptides exhibit a high affinity for the CCK receptor of beta-cells and have an insulinotropic effect much higher than CCK(4)." @default.
• W2019757429 created "2016-06-24" @default.
• W2019757429 creator A5032866850 @default.
• W2019757429 creator A5034111326 @default.
• W2019757429 date "2000-01-01" @default.
• W2019757429 modified "2023-09-25" @default.
• W2019757429 title "Biological Effects of Newly Synthesized Cholecystokinin Analogs" @default.
• W2019757429 cites W129489573 @default.
• W2019757429 cites W1502195451 @default.
• W2019757429 cites W1907739346 @default.
• W2019757429 cites W1944103599 @default.
• W2019757429 cites W1963988260 @default.
• W2019757429 cites W1964387344 @default.
• W2019757429 cites W1973847770 @default.
• W2019757429 cites W1974330785 @default.
• W2019757429 cites W1978790290 @default.
• W2019757429 cites W1979046104 @default.
• W2019757429 cites W1979100850 @default.
• W2019757429 cites W1980338241 @default.
• W2019757429 cites W1988646125 @default.
• W2019757429 cites W1991714764 @default.
• W2019757429 cites W2023687924 @default.
• W2019757429 cites W2027513761 @default.
• W2019757429 cites W2031077718 @default.
• W2019757429 cites W2040595653 @default.
• W2019757429 cites W2045991343 @default.
• W2019757429 cites W2063720970 @default.
• W2019757429 cites W2071188574 @default.
• W2019757429 cites W2078128058 @default.
• W2019757429 cites W2080827424 @default.
• W2019757429 cites W2081004928 @default.
• W2019757429 cites W2084290953 @default.
• W2019757429 cites W2085361292 @default.
• W2019757429 cites W2099077569 @default.
• W2019757429 cites W2138199172 @default.
• W2019757429 cites W2153029682 @default.
• W2019757429 cites W2155524113 @default.
• W2019757429 cites W2157865424 @default.
• W2019757429 cites W2209036429 @default.
• W2019757429 cites W2408093208 @default.
• W2019757429 cites W2414109702 @default.
• W2019757429 cites W2686433753 @default.
• W2019757429 cites W2006002238 @default.
• W2019757429 doi "https://doi.org/10.1159/000023564" @default.
• W2019757429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11044801" @default.
• W2019757429 hasPublicationYear "2000" @default.
• W2019757429 type Work @default.
• W2019757429 sameAs 2019757429 @default.
• W2019757429 citedByCount "0" @default.
• W2019757429 crossrefType "journal-article" @default.
• W2019757429 hasAuthorship W2019757429A5032866850 @default.
• W2019757429 hasAuthorship W2019757429A5034111326 @default.
• W2019757429 hasConcept C103395026 @default.
• W2019757429 hasConcept C116073593 @default.
• W2019757429 hasConcept C126322002 @default.
• W2019757429 hasConcept C134018914 @default.
• W2019757429 hasConcept C170493617 @default.
• W2019757429 hasConcept C185592680 @default.
• W2019757429 hasConcept C202751555 @default.
• W2019757429 hasConcept C2776885963 @default.
• W2019757429 hasConcept C2777226302 @default.
• W2019757429 hasConcept C2777593968 @default.
• W2019757429 hasConcept C2777951760 @default.
• W2019757429 hasConcept C2778764654 @default.
• W2019757429 hasConcept C32110497 @default.
• W2019757429 hasConcept C46699223 @default.
• W2019757429 hasConcept C55493867 @default.
• W2019757429 hasConcept C56191518 @default.
• W2019757429 hasConcept C71315377 @default.
• W2019757429 hasConcept C71924100 @default.
• W2019757429 hasConcept C86803240 @default.
• W2019757429 hasConceptScore W2019757429C103395026 @default.
• W2019757429 hasConceptScore W2019757429C116073593 @default.
• W2019757429 hasConceptScore W2019757429C126322002 @default.
• W2019757429 hasConceptScore W2019757429C134018914 @default.
• W2019757429 hasConceptScore W2019757429C170493617 @default.
• W2019757429 hasConceptScore W2019757429C185592680 @default.
• W2019757429 hasConceptScore W2019757429C202751555 @default.
• W2019757429 hasConceptScore W2019757429C2776885963 @default.
• W2019757429 hasConceptScore W2019757429C2777226302 @default.
• W2019757429 hasConceptScore W2019757429C2777593968 @default.
• W2019757429 hasConceptScore W2019757429C2777951760 @default.
• W2019757429 hasConceptScore W2019757429C2778764654 @default.
• W2019757429 hasConceptScore W2019757429C32110497 @default.
• W2019757429 hasConceptScore W2019757429C46699223 @default.
• W2019757429 hasConceptScore W2019757429C55493867 @default.
• W2019757429 hasConceptScore W2019757429C56191518 @default.
• W2019757429 hasConceptScore W2019757429C71315377 @default.
• W2019757429 hasConceptScore W2019757429C71924100 @default.
• W2019757429 hasConceptScore W2019757429C86803240 @default.
• W2019757429 hasIssue "4" @default.
• W2019757429 hasLocation W20197574291 @default.
• W2019757429 hasLocation W20197574292 @default.
• W2019757429 hasOpenAccess W2019757429 @default.
• W2019757429 hasPrimaryLocation W20197574291 @default.
• W2019757429 hasRelatedWork W1977702912 @default.
• W2019757429 hasRelatedWork W1982594208 @default.
• W2019757429 hasRelatedWork W1993973335 @default.

• next