FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019758497> ?p ?o ?g. }

• W2019758497 endingPage "811" @default.
• W2019758497 startingPage "802" @default.
• W2019758497 abstract "Abstract We aimed to setup a noninvasive and well‐controlled methodology for evaluation of the cerebrovascular response in mice (C57BL/6J; 12 weeks). Therefore we applied a normo‐, hypo‐, and hyperventilation paradigm combined with arterial spin labeling and monitoring of the expired CO 2 (expCO 2 ) ( n = 7) or arterial pCO 2 (apCO 2 ) ( n = 12). Reducing the tidal volume by 25% and the respiratory rate by 20% resulted in hypercapnia (apCO 2 from 33 ± 6 mmHg to 64 ± 16 mmHg). Increasing the respiratory rate by 25% and the tidal volume by 20% decreased apCO 2 to 22 ± 5 mmHg. Cerebral blood flow (CBF) was 82 ± 21, 163 ± 41 and 64 ± 18 mL/100 g/min during normo, hypo‐, and hyperventilation, respectively (midbrain). The correlation of apCO 2 and CBF levels resulted in a cerebrovascular response of 2.7 ± 0.3, 2.1 ± 0.3, 2.1 ± 0.3, and 3.7 ± 0.5 mL/100 g/min/mmHg for midbrain, cortex, hippocampus and thalamus, respectively. As expCO 2 levels were correlated with apCO 2 ( r 2 = 0.86; n = 4) and CBF ( r 2 = 0.67) a cerebrovascular response based on simultaneously recorded CBF and expCO 2 levels could be derived (3.3 ± 0.5, 2.5 ± 0.4, 3.0 ± 0.4, and 4.5 ± 0.6 mL/100 g/min/mmHg; order as above). A cross‐over experiment resulted in similar responses. In conclusion, this protocol allows evaluating basal CBF and cerebrovascular response in mice under well‐controlled conditions by simply changing ventilator settings and correlating CBF with apCO 2 and/or simultaneously obtained expCO 2 . Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc." @default.
• W2019758497 created "2016-06-24" @default.
• W2019758497 creator A5004293803 @default.
• W2019758497 creator A5034384200 @default.
• W2019758497 creator A5035825547 @default.
• W2019758497 creator A5040864692 @default.
• W2019758497 creator A5062397535 @default.
• W2019758497 creator A5076198690 @default.
• W2019758497 creator A5080540409 @default.
• W2019758497 date "2011-07-11" @default.
• W2019758497 modified "2023-10-10" @default.
• W2019758497 title "Response of mouse brain perfusion to hypo- and hyperventilation measured by arterial spin labeling" @default.
• W2019758497 cites W1966930409 @default.
• W2019758497 cites W1976099054 @default.
• W2019758497 cites W1989575676 @default.
• W2019758497 cites W1990544721 @default.
• W2019758497 cites W1992477463 @default.
• W2019758497 cites W1994192509 @default.
• W2019758497 cites W1996498530 @default.
• W2019758497 cites W1998128958 @default.
• W2019758497 cites W2009224600 @default.
• W2019758497 cites W2013650284 @default.
• W2019758497 cites W2021496866 @default.
• W2019758497 cites W2021975189 @default.
• W2019758497 cites W2022879757 @default.
• W2019758497 cites W2031516169 @default.
• W2019758497 cites W2043811549 @default.
• W2019758497 cites W2049007669 @default.
• W2019758497 cites W2062741155 @default.
• W2019758497 cites W2068237805 @default.
• W2019758497 cites W2069848438 @default.
• W2019758497 cites W2071767826 @default.
• W2019758497 cites W2074334688 @default.
• W2019758497 cites W2080349548 @default.
• W2019758497 cites W2083633501 @default.
• W2019758497 cites W2086553401 @default.
• W2019758497 cites W2090004399 @default.
• W2019758497 cites W2093325269 @default.
• W2019758497 cites W2102674375 @default.
• W2019758497 cites W2104483710 @default.
• W2019758497 cites W2120043086 @default.
• W2019758497 cites W2132516831 @default.
• W2019758497 cites W2152346792 @default.
• W2019758497 cites W2161380588 @default.
• W2019758497 cites W2162294352 @default.
• W2019758497 cites W2168534558 @default.
• W2019758497 cites W2168542458 @default.
• W2019758497 cites W2170363172 @default.
• W2019758497 cites W4233867216 @default.
• W2019758497 doi "https://doi.org/10.1002/mrm.23060" @default.
• W2019758497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21748794" @default.
• W2019758497 hasPublicationYear "2011" @default.
• W2019758497 type Work @default.
• W2019758497 sameAs 2019758497 @default.
• W2019758497 citedByCount "10" @default.
• W2019758497 countsByYear W20197584972014 @default.
• W2019758497 countsByYear W20197584972015 @default.
• W2019758497 countsByYear W20197584972016 @default.
• W2019758497 countsByYear W20197584972018 @default.
• W2019758497 countsByYear W20197584972019 @default.
• W2019758497 countsByYear W20197584972020 @default.
• W2019758497 countsByYear W20197584972021 @default.
• W2019758497 countsByYear W20197584972023 @default.
• W2019758497 crossrefType "journal-article" @default.
• W2019758497 hasAuthorship W2019758497A5004293803 @default.
• W2019758497 hasAuthorship W2019758497A5034384200 @default.
• W2019758497 hasAuthorship W2019758497A5035825547 @default.
• W2019758497 hasAuthorship W2019758497A5040864692 @default.
• W2019758497 hasAuthorship W2019758497A5062397535 @default.
• W2019758497 hasAuthorship W2019758497A5076198690 @default.
• W2019758497 hasAuthorship W2019758497A5080540409 @default.
• W2019758497 hasBestOaLocation W20197584971 @default.
• W2019758497 hasConcept C126322002 @default.
• W2019758497 hasConcept C126838900 @default.
• W2019758497 hasConcept C146957229 @default.
• W2019758497 hasConcept C157767197 @default.
• W2019758497 hasConcept C164705383 @default.
• W2019758497 hasConcept C185592680 @default.
• W2019758497 hasConcept C2777037550 @default.
• W2019758497 hasConcept C2777257755 @default.
• W2019758497 hasConcept C2777449187 @default.
• W2019758497 hasConcept C2777953023 @default.
• W2019758497 hasConcept C2778866228 @default.
• W2019758497 hasConcept C2779246727 @default.
• W2019758497 hasConcept C3018723549 @default.
• W2019758497 hasConcept C42219234 @default.
• W2019758497 hasConcept C534529494 @default.
• W2019758497 hasConcept C71924100 @default.
• W2019758497 hasConcept C8213797 @default.
• W2019758497 hasConcept C84393581 @default.
• W2019758497 hasConceptScore W2019758497C126322002 @default.
• W2019758497 hasConceptScore W2019758497C126838900 @default.
• W2019758497 hasConceptScore W2019758497C146957229 @default.
• W2019758497 hasConceptScore W2019758497C157767197 @default.
• W2019758497 hasConceptScore W2019758497C164705383 @default.
• W2019758497 hasConceptScore W2019758497C185592680 @default.
• W2019758497 hasConceptScore W2019758497C2777037550 @default.
• W2019758497 hasConceptScore W2019758497C2777257755 @default.

• next