FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019762775> ?p ?o ?g. }

• W2019762775 endingPage "1324" @default.
• W2019762775 startingPage "1317" @default.
• W2019762775 abstract "1. Certain compounds (e.g., the immunomodulator tilorone and congeners) are able to induce lysosomal storage of sulphated glycosaminoglycans (GAG), thus, producing cytological and biochemical alterations reminiscent of the inherited mucopolysaccharidoses. The drug-induced GAG storage has been studied in cultured fibroblasts of several species and in rats, and it is likely to occur also in humans. 2. The cytological hallmarks of GAG storage are enlarged lysosomes congested with material that is intensely stained by cationic dyes. With respect to fixation techniques, one has to keep in mind that the GAGs are highly water-soluble and are leached during conventional fixation and tissue processing. Biochemically, the elevation of GAG contents in tissues and cultured fibroblasts is due to storage of dermatan sulphate, predominantly. 3. The molecular structure of the potent inducers of GAG storage is characterized by a planar tricyclic aromatic ring system that is symmetrically substituted with two side chains of 4-5 sigma bond length, each carrying a protonizable nitrogen atom. The lysosomal storage of GAG is accompanied by lysosomal accumulation of the inducing drug, with the molar ratio of drug to GAG-disaccharide unit amounting to > 1:1. The reversibility of GAG storage is rather slow. 4. The pathogenic mechanisms underlying the drug side effects are discussed and the following hypothesis is put forward: The compounds in question are lysosomotropic weak bases. They get trapped in the acidic lysosomes and accumulate highly there. Physicochemical data suggest that the drugs form complexes with the sulphated GAGs, particularly with dermatan sulphate: The positively charged nitrogen atoms of the drug side chains interact with the negative charges of sulphate and carboxy groups of the GAGs, thereby crosslinking at least two GAG helices. Moreover, the interlinking drug molecules form parallel stacks resulting from interaction of the aromatic pi-electrons of the planar ring systems. This further stabilizes the complexes. The GAGs within the complexes are thought to be resistant to the degrading lysosomal enzymes. 5. Drug-induced GAG storage has not been directly demonstrated in man. Yet, clinical reports on keratopathy and basophilic cytoplasmic inclusions in blood lymphocytes of tilorone-treated patients suggest that this drug side effect may also occur in man." @default.
• W2019762775 created "2016-06-24" @default.
• W2019762775 creator A5064815553 @default.
• W2019762775 creator A5080561724 @default.
• W2019762775 creator A5091664271 @default.
• W2019762775 date "1996-12-01" @default.
• W2019762775 modified "2023-10-18" @default.
• W2019762775 title "Drug-induced lysosomal storage of sulphated glycosaminoglycans" @default.
• W2019762775 cites W10640494 @default.
• W2019762775 cites W1160821720 @default.
• W2019762775 cites W1558789523 @default.
• W2019762775 cites W1950519844 @default.
• W2019762775 cites W1965040183 @default.
• W2019762775 cites W1979050767 @default.
• W2019762775 cites W1979094327 @default.
• W2019762775 cites W1979599145 @default.
• W2019762775 cites W1982843733 @default.
• W2019762775 cites W1984654098 @default.
• W2019762775 cites W1986181566 @default.
• W2019762775 cites W1986847719 @default.
• W2019762775 cites W1990540278 @default.
• W2019762775 cites W1992645166 @default.
• W2019762775 cites W1998571985 @default.
• W2019762775 cites W1999824699 @default.
• W2019762775 cites W2000172237 @default.
• W2019762775 cites W2014092532 @default.
• W2019762775 cites W2027760703 @default.
• W2019762775 cites W2035467252 @default.
• W2019762775 cites W2053329304 @default.
• W2019762775 cites W2055635996 @default.
• W2019762775 cites W2056362847 @default.
• W2019762775 cites W2058003671 @default.
• W2019762775 cites W2059208362 @default.
• W2019762775 cites W2061536310 @default.
• W2019762775 cites W2065710740 @default.
• W2019762775 cites W2070163884 @default.
• W2019762775 cites W2074629637 @default.
• W2019762775 cites W2141514409 @default.
• W2019762775 cites W2167948410 @default.
• W2019762775 cites W218360407 @default.
• W2019762775 cites W2326494703 @default.
• W2019762775 cites W2328701583 @default.
• W2019762775 cites W2328998534 @default.
• W2019762775 cites W2329614367 @default.
• W2019762775 cites W2334436350 @default.
• W2019762775 cites W2405898690 @default.
• W2019762775 cites W2418607675 @default.
• W2019762775 cites W4251144546 @default.
• W2019762775 cites W4376596386 @default.
• W2019762775 cites W2012110046 @default.
• W2019762775 doi "https://doi.org/10.1016/s0306-3623(96)00150-4" @default.
• W2019762775 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9304401" @default.
• W2019762775 hasPublicationYear "1996" @default.
• W2019762775 type Work @default.
• W2019762775 sameAs 2019762775 @default.
• W2019762775 citedByCount "18" @default.
• W2019762775 countsByYear W20197627752012 @default.
• W2019762775 countsByYear W20197627752013 @default.
• W2019762775 countsByYear W20197627752015 @default.
• W2019762775 countsByYear W20197627752020 @default.
• W2019762775 countsByYear W20197627752023 @default.
• W2019762775 crossrefType "journal-article" @default.
• W2019762775 hasAuthorship W2019762775A5064815553 @default.
• W2019762775 hasAuthorship W2019762775A5080561724 @default.
• W2019762775 hasAuthorship W2019762775A5091664271 @default.
• W2019762775 hasConcept C12554922 @default.
• W2019762775 hasConcept C153074725 @default.
• W2019762775 hasConcept C185592680 @default.
• W2019762775 hasConcept C2778041096 @default.
• W2019762775 hasConcept C2778066728 @default.
• W2019762775 hasConcept C55493867 @default.
• W2019762775 hasConcept C86803240 @default.
• W2019762775 hasConcept C95444343 @default.
• W2019762775 hasConceptScore W2019762775C12554922 @default.
• W2019762775 hasConceptScore W2019762775C153074725 @default.
• W2019762775 hasConceptScore W2019762775C185592680 @default.
• W2019762775 hasConceptScore W2019762775C2778041096 @default.
• W2019762775 hasConceptScore W2019762775C2778066728 @default.
• W2019762775 hasConceptScore W2019762775C55493867 @default.
• W2019762775 hasConceptScore W2019762775C86803240 @default.
• W2019762775 hasConceptScore W2019762775C95444343 @default.
• W2019762775 hasIssue "8" @default.
• W2019762775 hasLocation W20197627751 @default.
• W2019762775 hasLocation W20197627752 @default.
• W2019762775 hasOpenAccess W2019762775 @default.
• W2019762775 hasPrimaryLocation W20197627751 @default.
• W2019762775 hasRelatedWork W1987032391 @default.
• W2019762775 hasRelatedWork W2016880296 @default.
• W2019762775 hasRelatedWork W2044864133 @default.
• W2019762775 hasRelatedWork W2414975270 @default.
• W2019762775 hasRelatedWork W2759760669 @default.
• W2019762775 hasRelatedWork W2951747690 @default.
• W2019762775 hasRelatedWork W2963757465 @default.
• W2019762775 hasRelatedWork W3134059847 @default.
• W2019762775 hasRelatedWork W4285275743 @default.
• W2019762775 hasRelatedWork W55321852 @default.
• W2019762775 hasVolume "27" @default.
• W2019762775 isParatext "false" @default.

• next