FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019768085> ?p ?o ?g. }

• W2019768085 endingPage "648" @default.
• W2019768085 startingPage "643" @default.
• W2019768085 abstract "Kava (Piper methysticum) is a plant-based medicine, which has been previously shown to reduce anxiety. To date, however, no placebo-controlled trial assessing kava in the treatment of generalized anxiety disorder (GAD) has been completed. A total of 75 participants with GAD and no comorbid mood disorder were enrolled in a 6-week double-blind trial of an aqueous extract of kava (120/240 mg of kavalactones per day depending on response) versus placebo. γ-Aminobutyric acid (GABA) and noradrenaline transporter polymorphisms were also analyzed as potential pharmacogenetic markers of response. Reduction in anxiety was measured using the Hamilton Anxiety Rating Scale (HAMA) as the primary outcome. Intention-to-treat analysis was performed on 58 participants who met inclusion criteria after an initial 1 week placebo run-in phase. Results revealed a significant reduction in anxiety for the kava group compared with the placebo group with a moderate effect size (P = 0.046, Cohen d = 0.62). Among participants with moderate to severe Diagnostic and Statistical Manual of Mental Disorders-diagnosed GAD, this effect was larger (P = 0.02; d = 0.82). At conclusion of the controlled phase, 26% of the kava group were classified as remitted (HAMA ≤ 7) compared with 6% of the placebo group (P = 0.04). Within the kava group, GABA transporter polymorphisms rs2601126 (P = 0.021) and rs2697153 (P = 0.046) were associated with HAMA reduction. Kava was well tolerated, and aside from more headaches reported in the kava group (P = 0.05), no other significant differences between groups occurred for any other adverse effects, nor for liver function tests. Standardized kava may be a moderately effective short-term option for the treatment of GAD. Furthermore, specific GABA transporter polymorphisms appear to potentially modify anxiolytic response to kava." @default.
• W2019768085 created "2016-06-24" @default.
• W2019768085 creator A5007196067 @default.
• W2019768085 creator A5013936218 @default.
• W2019768085 creator A5017556300 @default.
• W2019768085 creator A5019675536 @default.
• W2019768085 creator A5044685900 @default.
• W2019768085 creator A5044776763 @default.
• W2019768085 creator A5055172170 @default.
• W2019768085 creator A5069558155 @default.
• W2019768085 creator A5082946700 @default.
• W2019768085 creator A5091303329 @default.
• W2019768085 date "2013-10-01" @default.
• W2019768085 modified "2023-09-23" @default.
• W2019768085 title "Kava in the Treatment of Generalized Anxiety Disorder" @default.
• W2019768085 cites W1553748355 @default.
• W2019768085 cites W1877013367 @default.
• W2019768085 cites W1962774165 @default.
• W2019768085 cites W1981701508 @default.
• W2019768085 cites W1987838528 @default.
• W2019768085 cites W2004990154 @default.
• W2019768085 cites W2006084435 @default.
• W2019768085 cites W2023769271 @default.
• W2019768085 cites W2029899813 @default.
• W2019768085 cites W2035108699 @default.
• W2019768085 cites W2041596130 @default.
• W2019768085 cites W2048520342 @default.
• W2019768085 cites W2049546836 @default.
• W2019768085 cites W2056986534 @default.
• W2019768085 cites W2057740638 @default.
• W2019768085 cites W2066308284 @default.
• W2019768085 cites W2088705310 @default.
• W2019768085 cites W2089786831 @default.
• W2019768085 cites W2091881469 @default.
• W2019768085 cites W2093280242 @default.
• W2019768085 cites W2094862387 @default.
• W2019768085 cites W2103607628 @default.
• W2019768085 cites W2131823335 @default.
• W2019768085 cites W2154973070 @default.
• W2019768085 cites W2160070901 @default.
• W2019768085 cites W2329856663 @default.
• W2019768085 cites W4238079920 @default.
• W2019768085 cites W4256277653 @default.
• W2019768085 doi "https://doi.org/10.1097/jcp.0b013e318291be67" @default.
• W2019768085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23635869" @default.
• W2019768085 hasPublicationYear "2013" @default.
• W2019768085 type Work @default.
• W2019768085 sameAs 2019768085 @default.
• W2019768085 citedByCount "94" @default.
• W2019768085 countsByYear W20197680852014 @default.
• W2019768085 countsByYear W20197680852015 @default.
• W2019768085 countsByYear W20197680852016 @default.
• W2019768085 countsByYear W20197680852017 @default.
• W2019768085 countsByYear W20197680852018 @default.
• W2019768085 countsByYear W20197680852019 @default.
• W2019768085 countsByYear W20197680852020 @default.
• W2019768085 countsByYear W20197680852021 @default.
• W2019768085 countsByYear W20197680852022 @default.
• W2019768085 countsByYear W20197680852023 @default.
• W2019768085 crossrefType "journal-article" @default.
• W2019768085 hasAuthorship W2019768085A5007196067 @default.
• W2019768085 hasAuthorship W2019768085A5013936218 @default.
• W2019768085 hasAuthorship W2019768085A5017556300 @default.
• W2019768085 hasAuthorship W2019768085A5019675536 @default.
• W2019768085 hasAuthorship W2019768085A5044685900 @default.
• W2019768085 hasAuthorship W2019768085A5044776763 @default.
• W2019768085 hasAuthorship W2019768085A5055172170 @default.
• W2019768085 hasAuthorship W2019768085A5069558155 @default.
• W2019768085 hasAuthorship W2019768085A5082946700 @default.
• W2019768085 hasAuthorship W2019768085A5091303329 @default.
• W2019768085 hasConcept C118552586 @default.
• W2019768085 hasConcept C126322002 @default.
• W2019768085 hasConcept C142724271 @default.
• W2019768085 hasConcept C15744967 @default.
• W2019768085 hasConcept C170493617 @default.
• W2019768085 hasConcept C204787440 @default.
• W2019768085 hasConcept C27081682 @default.
• W2019768085 hasConcept C2776910463 @default.
• W2019768085 hasConcept C2778173252 @default.
• W2019768085 hasConcept C2779911313 @default.
• W2019768085 hasConcept C558461103 @default.
• W2019768085 hasConcept C71924100 @default.
• W2019768085 hasConcept C90924648 @default.
• W2019768085 hasConceptScore W2019768085C118552586 @default.
• W2019768085 hasConceptScore W2019768085C126322002 @default.
• W2019768085 hasConceptScore W2019768085C142724271 @default.
• W2019768085 hasConceptScore W2019768085C15744967 @default.
• W2019768085 hasConceptScore W2019768085C170493617 @default.
• W2019768085 hasConceptScore W2019768085C204787440 @default.
• W2019768085 hasConceptScore W2019768085C27081682 @default.
• W2019768085 hasConceptScore W2019768085C2776910463 @default.
• W2019768085 hasConceptScore W2019768085C2778173252 @default.
• W2019768085 hasConceptScore W2019768085C2779911313 @default.
• W2019768085 hasConceptScore W2019768085C558461103 @default.
• W2019768085 hasConceptScore W2019768085C71924100 @default.
• W2019768085 hasConceptScore W2019768085C90924648 @default.
• W2019768085 hasIssue "5" @default.
• W2019768085 hasLocation W20197680851 @default.

• next