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- W2019772287 abstract "In an effort to develop alternatives to hydroxamate-based matrix metalloproteinase inhibitors (MPIs), we have utilized the drug discovery program LUDI enhanced with the structural coordinates of a bioinorganic model complex. This method has yielded the first pyrone-based MPIs. The inhibitors demonstrate nanomolar potency against MMP-3 and are selective for MMP-3 over MMP-2 and MMP-1. We postulate that the potency and unusual selectivity profile of these MPI is attributable to the pyrone chelating group." @default.
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- W2019772287 date "2005-09-22" @default.
- W2019772287 modified "2023-10-03" @default.
- W2019772287 title "Potent, Selective Pyrone-Based Inhibitors of Stromelysin-1" @default.
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- W2019772287 doi "https://doi.org/10.1021/ja054558o" @default.
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