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- W2019772485 endingPage "696" @default.
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- W2019772485 abstract "This review article describes the pathways and mechanisms of endocytosis and post-endocytic sorting of the EGF receptor (EGFR/ErbB1) and other members of the ErbB family. Growth factor binding to EGFR accelerates its internalization through clathrin-coated pits which is followed by the efficient lysosomal targeting of internalized receptors and results in receptor down-regulation. The role of EGFR interaction with the Grb2 adaptor protein and Cbl ubiquitin ligase, and receptor ubiquitination in the clathrin-dependent internalization and sorting of EGFR in multivesicular endosomes is discussed. Activation and phosphorylation of ErbB2, ErbB3 and ErbB4 also results in their ubiquitination. However, these ErbBs are internalized and targeted to lysosomes less efficiently than EGFR. When overexpressed endocytosis-impaired ErbBs may inhibit the internalization and degradation of EGFR." @default.
- W2019772485 created "2016-06-24" @default.
- W2019772485 creator A5001266319 @default.
- W2019772485 creator A5073726679 @default.
- W2019772485 date "2009-02-01" @default.
- W2019772485 modified "2023-10-12" @default.
- W2019772485 title "Endocytosis and intracellular trafficking of ErbBs" @default.
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