FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019777747> ?p ?o ?g. }

• W2019777747 endingPage "1492" @default.
• W2019777747 startingPage "1484" @default.
• W2019777747 abstract "Objective: Extreme anemia threatens myocardial oxygen supply by 1) a decline of arterial oxygen content and 2) by a decline of mean aortic pressure (MAP) and thus coronary perfusion pressure. Standard treatment of low arterial oxygen content includes ventilation with pure oxygen and the transfusion of red blood cells. However, it is unknown whether the stabilization of MAP and coronary perfusion pressure with norepinephrine as the sole therapeutic modality may also increase tolerance to extreme anemia and thus improve outcome. Design: Prospective, randomized, controlled study. Setting: Experimental animal laboratory of a university hospital. Subjects: A total of 28 anesthetized, mechanically ventilated pigs. Interventions and Measurements: In the first protocol, 14 anesthetized pigs were hemodiluted by exchange of whole blood for 6% hydroxyethyl starch (200,000:0.5) until the individual critical hemoglobin concentration was reached. For the next 6 hrs, animals were either observed without any further intervention (control group) or their MAP was maintained by adapted infusion of norepinephrine (norepinephrine group). The main outcome variable of this protocol was the 6-hr mortality in both groups. In the second protocol, 14 anesthetized pigs received hemodilution until death. In seven animals, no intervention was performed during the hemodilution procedure, whereas in the other seven animals, MAP was maintained at >60 mm Hg by adapted infusion of norepinephrine. The main outcome variable of this protocol was the maximum exchangeable blood volume until death. Main Results: MAP stabilization with norepinephrine reduced the 6-hr mortality at the critical hemoglobin concentration from 100% to 14%. Maintaining MAP by adapted norepinephrine infusion during the hemodilution procedure allowed for the exchange of 125 (110/126) (median [quartile 1/quartile 3]) mL/kg blood (163% of blood volume) in the norepinephrine group, whereas only 76 (73/91) mL/kg blood (104% of blood volume) could be exchanged in the control group. Conclusions: Application of norepinephrine can be judged a first-line intervention to bridge acute anemia via a stabilization of MAP and coronary perfusion pressure. However, due to the relevant side effects of norepinephrine, its sole long-term use during extreme anemia without concomitant transfusion of erythrocytes is not advised." @default.
• W2019777747 created "2016-06-24" @default.
• W2019777747 creator A5001747202 @default.
• W2019777747 creator A5003136852 @default.
• W2019777747 creator A5004771457 @default.
• W2019777747 creator A5012479888 @default.
• W2019777747 creator A5049650973 @default.
• W2019777747 creator A5057169235 @default.
• W2019777747 creator A5062309216 @default.
• W2019777747 date "2007-06-01" @default.
• W2019777747 modified "2023-09-25" @default.
• W2019777747 title "Norepinephrine increases tolerance to acute anemia*" @default.
• W2019777747 cites W1929398776 @default.
• W2019777747 cites W1998298127 @default.
• W2019777747 cites W2013339541 @default.
• W2019777747 cites W2022280390 @default.
• W2019777747 cites W2031551417 @default.
• W2019777747 cites W2034427990 @default.
• W2019777747 cites W2042672404 @default.
• W2019777747 cites W2043999340 @default.
• W2019777747 cites W2044668180 @default.
• W2019777747 cites W2045122701 @default.
• W2019777747 cites W2046053280 @default.
• W2019777747 cites W2046059415 @default.
• W2019777747 cites W2052409878 @default.
• W2019777747 cites W2059816999 @default.
• W2019777747 cites W2071016207 @default.
• W2019777747 cites W2073379085 @default.
• W2019777747 cites W2075077844 @default.
• W2019777747 cites W2098885024 @default.
• W2019777747 cites W2106763736 @default.
• W2019777747 cites W2107455154 @default.
• W2019777747 cites W2119459514 @default.
• W2019777747 cites W2125108250 @default.
• W2019777747 cites W2132358997 @default.
• W2019777747 cites W2132694135 @default.
• W2019777747 cites W2168010680 @default.
• W2019777747 cites W2174297323 @default.
• W2019777747 cites W2272510615 @default.
• W2019777747 doi "https://doi.org/10.1097/01.ccm.0000265740.62130.1c" @default.
• W2019777747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17452931" @default.
• W2019777747 hasPublicationYear "2007" @default.
• W2019777747 type Work @default.
• W2019777747 sameAs 2019777747 @default.
• W2019777747 citedByCount "30" @default.
• W2019777747 countsByYear W20197777472012 @default.
• W2019777747 countsByYear W20197777472013 @default.
• W2019777747 countsByYear W20197777472014 @default.
• W2019777747 countsByYear W20197777472015 @default.
• W2019777747 countsByYear W20197777472016 @default.
• W2019777747 countsByYear W20197777472017 @default.
• W2019777747 countsByYear W20197777472018 @default.
• W2019777747 countsByYear W20197777472022 @default.
• W2019777747 countsByYear W20197777472023 @default.
• W2019777747 crossrefType "journal-article" @default.
• W2019777747 hasAuthorship W2019777747A5001747202 @default.
• W2019777747 hasAuthorship W2019777747A5003136852 @default.
• W2019777747 hasAuthorship W2019777747A5004771457 @default.
• W2019777747 hasAuthorship W2019777747A5012479888 @default.
• W2019777747 hasAuthorship W2019777747A5049650973 @default.
• W2019777747 hasAuthorship W2019777747A5057169235 @default.
• W2019777747 hasAuthorship W2019777747A5062309216 @default.
• W2019777747 hasConcept C126322002 @default.
• W2019777747 hasConcept C146957229 @default.
• W2019777747 hasConcept C164705383 @default.
• W2019777747 hasConcept C2776452961 @default.
• W2019777747 hasConcept C2777953023 @default.
• W2019777747 hasConcept C2778248108 @default.
• W2019777747 hasConcept C2778514916 @default.
• W2019777747 hasConcept C42219234 @default.
• W2019777747 hasConcept C513476851 @default.
• W2019777747 hasConcept C71924100 @default.
• W2019777747 hasConcept C84393581 @default.
• W2019777747 hasConceptScore W2019777747C126322002 @default.
• W2019777747 hasConceptScore W2019777747C146957229 @default.
• W2019777747 hasConceptScore W2019777747C164705383 @default.
• W2019777747 hasConceptScore W2019777747C2776452961 @default.
• W2019777747 hasConceptScore W2019777747C2777953023 @default.
• W2019777747 hasConceptScore W2019777747C2778248108 @default.
• W2019777747 hasConceptScore W2019777747C2778514916 @default.
• W2019777747 hasConceptScore W2019777747C42219234 @default.
• W2019777747 hasConceptScore W2019777747C513476851 @default.
• W2019777747 hasConceptScore W2019777747C71924100 @default.
• W2019777747 hasConceptScore W2019777747C84393581 @default.
• W2019777747 hasIssue "6" @default.
• W2019777747 hasLocation W20197777471 @default.
• W2019777747 hasLocation W20197777472 @default.
• W2019777747 hasOpenAccess W2019777747 @default.
• W2019777747 hasPrimaryLocation W20197777471 @default.
• W2019777747 hasRelatedWork W2003797084 @default.
• W2019777747 hasRelatedWork W2020073312 @default.
• W2019777747 hasRelatedWork W2029739536 @default.
• W2019777747 hasRelatedWork W2084461439 @default.
• W2019777747 hasRelatedWork W2134900585 @default.
• W2019777747 hasRelatedWork W2188165554 @default.
• W2019777747 hasRelatedWork W2324925659 @default.
• W2019777747 hasRelatedWork W2411372493 @default.
• W2019777747 hasRelatedWork W3030088539 @default.

• next