Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019785445> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2019785445 endingPage "224" @default.
- W2019785445 startingPage "224" @default.
- W2019785445 abstract "Allograft (H-2DdKd)-induced macrophages (AIM) in C57BL/6 (H-2DbKb) mice exhibit major histocompatibility complex (MHC) haplotype-specific killing of allografts in a macrophage MHC receptor 1 (MMR1; for H-2Dd)- and MMR2 (for H-2Kd)-dependent manner. Recently, we showed HLA-B62 to be a ligand for the human homologue of mouse MMR2. In the present study, we isolated a cDNA encoding the human homologue of mouse MMR1 and found HLA-B44 to be the sole ligand specific for the human MMR1 by using beads that had been conjugated with 80 kinds of HLA proteins. Flow cytometric analyses revealed that HLA-B44-conjugated beads are specifically bound to HEK293T cells expressing human MMR1, that HLA-B44 tetramers are bound to the human MMR1-transfected HEK293T cells with a dissociation constant of 3.0 × 10− 9 M, and that the interaction was completely inhibited by the addition of R15 monoclonal antibody specific for mouse MMR1. The MMR1 cDNA (1537-bp) encoded a 473-amino acid polypeptide and was expressed at least in part in the brain and peripheral blood mononuclear cells (PBMCs) or monocytes, but not in granulocytes or lymphocytes. PBMCs from 7 non-H-2Dd (non-self), but none from 5 H-2Dd (self), in-bred mice expressed mouse MMR1 specific for H-2Dd. In contrast, PBMCs from none of the 16 human volunteers expressed HLA-B44; whereas those from only 3 of these 16 volunteers expressed human MMR1.These results reveal that human MMR1 on monocytes is a novel receptor specific for HLA-B44." @default.
- W2019785445 created "2016-06-24" @default.
- W2019785445 creator A5020742985 @default.
- W2019785445 creator A5021050391 @default.
- W2019785445 creator A5026339055 @default.
- W2019785445 creator A5033678637 @default.
- W2019785445 creator A5063975935 @default.
- W2019785445 creator A5073617142 @default.
- W2019785445 creator A5077146906 @default.
- W2019785445 creator A5082123920 @default.
- W2019785445 creator A5084497296 @default.
- W2019785445 creator A5085850143 @default.
- W2019785445 date "1957-01-01" @default.
- W2019785445 modified "2023-10-16" @default.
- W2019785445 title "Experimental studies on the airborne infection of tuberculosis using P32-labelled bacilli" @default.
- W2019785445 doi "https://doi.org/10.1016/0020-708x(57)90160-6" @default.
- W2019785445 hasPublicationYear "1957" @default.
- W2019785445 type Work @default.
- W2019785445 sameAs 2019785445 @default.
- W2019785445 citedByCount "0" @default.
- W2019785445 crossrefType "journal-article" @default.
- W2019785445 hasAuthorship W2019785445A5020742985 @default.
- W2019785445 hasAuthorship W2019785445A5021050391 @default.
- W2019785445 hasAuthorship W2019785445A5026339055 @default.
- W2019785445 hasAuthorship W2019785445A5033678637 @default.
- W2019785445 hasAuthorship W2019785445A5063975935 @default.
- W2019785445 hasAuthorship W2019785445A5073617142 @default.
- W2019785445 hasAuthorship W2019785445A5077146906 @default.
- W2019785445 hasAuthorship W2019785445A5082123920 @default.
- W2019785445 hasAuthorship W2019785445A5084497296 @default.
- W2019785445 hasAuthorship W2019785445A5085850143 @default.
- W2019785445 hasConcept C104317684 @default.
- W2019785445 hasConcept C137061746 @default.
- W2019785445 hasConcept C147483822 @default.
- W2019785445 hasConcept C153911025 @default.
- W2019785445 hasConcept C159654299 @default.
- W2019785445 hasConcept C170493617 @default.
- W2019785445 hasConcept C174510640 @default.
- W2019785445 hasConcept C187882448 @default.
- W2019785445 hasConcept C188280979 @default.
- W2019785445 hasConcept C195616568 @default.
- W2019785445 hasConcept C202751555 @default.
- W2019785445 hasConcept C203014093 @default.
- W2019785445 hasConcept C207936829 @default.
- W2019785445 hasConcept C54009773 @default.
- W2019785445 hasConcept C542903549 @default.
- W2019785445 hasConcept C55493867 @default.
- W2019785445 hasConcept C86803240 @default.
- W2019785445 hasConceptScore W2019785445C104317684 @default.
- W2019785445 hasConceptScore W2019785445C137061746 @default.
- W2019785445 hasConceptScore W2019785445C147483822 @default.
- W2019785445 hasConceptScore W2019785445C153911025 @default.
- W2019785445 hasConceptScore W2019785445C159654299 @default.
- W2019785445 hasConceptScore W2019785445C170493617 @default.
- W2019785445 hasConceptScore W2019785445C174510640 @default.
- W2019785445 hasConceptScore W2019785445C187882448 @default.
- W2019785445 hasConceptScore W2019785445C188280979 @default.
- W2019785445 hasConceptScore W2019785445C195616568 @default.
- W2019785445 hasConceptScore W2019785445C202751555 @default.
- W2019785445 hasConceptScore W2019785445C203014093 @default.
- W2019785445 hasConceptScore W2019785445C207936829 @default.
- W2019785445 hasConceptScore W2019785445C54009773 @default.
- W2019785445 hasConceptScore W2019785445C542903549 @default.
- W2019785445 hasConceptScore W2019785445C55493867 @default.
- W2019785445 hasConceptScore W2019785445C86803240 @default.
- W2019785445 hasIssue "3-4" @default.
- W2019785445 hasLocation W20197854451 @default.
- W2019785445 hasOpenAccess W2019785445 @default.
- W2019785445 hasPrimaryLocation W20197854451 @default.
- W2019785445 hasRelatedWork W1604248381 @default.
- W2019785445 hasRelatedWork W1996575012 @default.
- W2019785445 hasRelatedWork W1999614011 @default.
- W2019785445 hasRelatedWork W2001280522 @default.
- W2019785445 hasRelatedWork W2039544316 @default.
- W2019785445 hasRelatedWork W2059923545 @default.
- W2019785445 hasRelatedWork W2060246599 @default.
- W2019785445 hasRelatedWork W2162389703 @default.
- W2019785445 hasRelatedWork W2400620861 @default.
- W2019785445 hasRelatedWork W2401891876 @default.
- W2019785445 hasVolume "2" @default.
- W2019785445 isParatext "false" @default.
- W2019785445 isRetracted "false" @default.
- W2019785445 magId "2019785445" @default.
- W2019785445 workType "article" @default.