Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019786727> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2019786727 abstract "When myo-2-[3H]inositol-labeled rabbit platelets were stimulated with 1 X 10(-9)M sn-3-AGEPC (platelet activating factor) for 5 s, the levels of [3H]inositol monophosphate (IP), [3H]inositol diphosphate (IP2), and [3H]inositol triphosphate (IP3) increased about 1.5-, 3-, and 5-fold, respectively. Formation of these inositol polyphosphates was strikingly independent of extracellular Ca2+. Inactive analogs of sn-3-AGEPC, i.e., lysoGEPC and stereoisomer sn-1-AGEPC, did not cause production of any inositol polyphosphate. Pretreatment of platelets with indomethacin (5 microM) had little effect on this phenomenon. On the other hand, a platelet activating factor antagonist, CV-3988, blocked the AGEPC-stimulated production of radioactive IP, IP2, and IP3. Similarly forskolin, an activator of adenylate cyclase, at 5 microM or above completely abolished AGEPC-induced aggregation, [3H]serotonin secretion, and formation of [3H]inositol polyphosphates. In the light of the emerging role of AGEPC in inflammation, hypotension, and other cardiovascular processes, studies with platelets reported here indicate that forskolin could be a useful tool for manipulating AGEPC responses. It is further concluded that AGEPC-induced formation of inositol polyphosphate is an early response specific to AGEPC, mediated via extracellular Ca2+-independent phosphoinositide phosphodiesterase, and could play a role in intracellular Ca2+ mobilization and platelet shape change." @default.
- W2019786727 created "2016-06-24" @default.
- W2019786727 creator A5086783302 @default.
- W2019786727 date "1985-08-01" @default.
- W2019786727 modified "2023-10-18" @default.
- W2019786727 title "Platelet activating factor-stimulated formation of inositol triphosphate in platelets and its regulation by various agents including Ca2+, indomethacin, CV-3988, and forskolin" @default.
- W2019786727 cites W1517662067 @default.
- W2019786727 cites W1543719240 @default.
- W2019786727 cites W1572918988 @default.
- W2019786727 cites W1577793849 @default.
- W2019786727 cites W1893528652 @default.
- W2019786727 cites W1927894522 @default.
- W2019786727 cites W1966336919 @default.
- W2019786727 cites W1971356555 @default.
- W2019786727 cites W1973090655 @default.
- W2019786727 cites W1977784192 @default.
- W2019786727 cites W1997882330 @default.
- W2019786727 cites W2004088054 @default.
- W2019786727 cites W2025881724 @default.
- W2019786727 cites W2045988801 @default.
- W2019786727 cites W2047400649 @default.
- W2019786727 cites W2047613580 @default.
- W2019786727 cites W2049504937 @default.
- W2019786727 cites W2056812477 @default.
- W2019786727 cites W2062023036 @default.
- W2019786727 cites W2068877244 @default.
- W2019786727 cites W2070111917 @default.
- W2019786727 cites W2078595704 @default.
- W2019786727 cites W2083774107 @default.
- W2019786727 cites W2089012764 @default.
- W2019786727 cites W2090276011 @default.
- W2019786727 cites W2162602750 @default.
- W2019786727 cites W2224206397 @default.
- W2019786727 cites W2228280428 @default.
- W2019786727 cites W2314347700 @default.
- W2019786727 cites W2419237941 @default.
- W2019786727 cites W33385424 @default.
- W2019786727 cites W2164671113 @default.
- W2019786727 doi "https://doi.org/10.1016/0003-9861(85)90075-x" @default.
- W2019786727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3875314" @default.
- W2019786727 hasPublicationYear "1985" @default.
- W2019786727 type Work @default.
- W2019786727 sameAs 2019786727 @default.
- W2019786727 citedByCount "40" @default.
- W2019786727 countsByYear W20197867272020 @default.
- W2019786727 crossrefType "journal-article" @default.
- W2019786727 hasAuthorship W2019786727A5086783302 @default.
- W2019786727 hasConcept C126322002 @default.
- W2019786727 hasConcept C134018914 @default.
- W2019786727 hasConcept C163235415 @default.
- W2019786727 hasConcept C170493617 @default.
- W2019786727 hasConcept C185592680 @default.
- W2019786727 hasConcept C2777427919 @default.
- W2019786727 hasConcept C2778618036 @default.
- W2019786727 hasConcept C2779020240 @default.
- W2019786727 hasConcept C2779276759 @default.
- W2019786727 hasConcept C2781387506 @default.
- W2019786727 hasConcept C28406088 @default.
- W2019786727 hasConcept C3018697912 @default.
- W2019786727 hasConcept C55493867 @default.
- W2019786727 hasConcept C71924100 @default.
- W2019786727 hasConcept C79879829 @default.
- W2019786727 hasConcept C86803240 @default.
- W2019786727 hasConcept C89560881 @default.
- W2019786727 hasConceptScore W2019786727C126322002 @default.
- W2019786727 hasConceptScore W2019786727C134018914 @default.
- W2019786727 hasConceptScore W2019786727C163235415 @default.
- W2019786727 hasConceptScore W2019786727C170493617 @default.
- W2019786727 hasConceptScore W2019786727C185592680 @default.
- W2019786727 hasConceptScore W2019786727C2777427919 @default.
- W2019786727 hasConceptScore W2019786727C2778618036 @default.
- W2019786727 hasConceptScore W2019786727C2779020240 @default.
- W2019786727 hasConceptScore W2019786727C2779276759 @default.
- W2019786727 hasConceptScore W2019786727C2781387506 @default.
- W2019786727 hasConceptScore W2019786727C28406088 @default.
- W2019786727 hasConceptScore W2019786727C3018697912 @default.
- W2019786727 hasConceptScore W2019786727C55493867 @default.
- W2019786727 hasConceptScore W2019786727C71924100 @default.
- W2019786727 hasConceptScore W2019786727C79879829 @default.
- W2019786727 hasConceptScore W2019786727C86803240 @default.
- W2019786727 hasConceptScore W2019786727C89560881 @default.
- W2019786727 hasLocation W20197867271 @default.
- W2019786727 hasLocation W20197867272 @default.
- W2019786727 hasOpenAccess W2019786727 @default.
- W2019786727 hasPrimaryLocation W20197867271 @default.
- W2019786727 hasRelatedWork W100332784 @default.
- W2019786727 hasRelatedWork W119987246 @default.
- W2019786727 hasRelatedWork W1977764086 @default.
- W2019786727 hasRelatedWork W1988883697 @default.
- W2019786727 hasRelatedWork W2051640678 @default.
- W2019786727 hasRelatedWork W2053909241 @default.
- W2019786727 hasRelatedWork W2088548584 @default.
- W2019786727 hasRelatedWork W2160452502 @default.
- W2019786727 hasRelatedWork W2175515186 @default.
- W2019786727 hasRelatedWork W256088671 @default.
- W2019786727 isParatext "false" @default.
- W2019786727 isRetracted "false" @default.
- W2019786727 magId "2019786727" @default.
- W2019786727 workType "article" @default.