Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019790163> ?p ?o ?g. }
- W2019790163 endingPage "256" @default.
- W2019790163 startingPage "245" @default.
- W2019790163 abstract "The Sir2 protein mediates gene silencing and repression of recombination at the rDNA repeats in budding yeast. Here we show that Sir2 executes these functions as a component of a nucleolar complex designated RENT (re gulator of n ucleolar silencing and t elophase exit). Net1, a core subunit of this complex, preferentially cross-links to the rDNA repeats, but not to silent DNA regions near telomeres or to active genes, and tethers the RENT complex to rDNA. Net1 is furthermore required for rDNA silencing and nucleolar integrity. During interphase, Net1 and Sir2 colocalize to a subdomain within the nucleolus, but at the end of mitosis a fraction of Sir2 leaves the nucleolus and disperses as foci throughout the nucleus, suggesting that the structure of rDNA silent chromatin changes during the cell cycle. Our findings suggest that a protein complex shown to regulate exit from mitosis is also involved in gene silencing." @default.
- W2019790163 created "2016-06-24" @default.
- W2019790163 creator A5011792309 @default.
- W2019790163 creator A5028945409 @default.
- W2019790163 creator A5033692642 @default.
- W2019790163 creator A5057228307 @default.
- W2019790163 creator A5057386104 @default.
- W2019790163 creator A5066867755 @default.
- W2019790163 creator A5080063862 @default.
- W2019790163 date "1999-04-01" @default.
- W2019790163 modified "2023-10-16" @default.
- W2019790163 title "Net1, a Sir2-Associated Nucleolar Protein Required for rDNA Silencing and Nucleolar Integrity" @default.
- W2019790163 cites W1511582654 @default.
- W2019790163 cites W1528082486 @default.
- W2019790163 cites W1963578989 @default.
- W2019790163 cites W1968112541 @default.
- W2019790163 cites W1968676663 @default.
- W2019790163 cites W1974750330 @default.
- W2019790163 cites W1985914869 @default.
- W2019790163 cites W1994369498 @default.
- W2019790163 cites W2000737623 @default.
- W2019790163 cites W2003798106 @default.
- W2019790163 cites W2005222967 @default.
- W2019790163 cites W2006094963 @default.
- W2019790163 cites W2006901859 @default.
- W2019790163 cites W2008187459 @default.
- W2019790163 cites W2021309301 @default.
- W2019790163 cites W2021432006 @default.
- W2019790163 cites W2026898742 @default.
- W2019790163 cites W2036347938 @default.
- W2019790163 cites W2044347050 @default.
- W2019790163 cites W2049488119 @default.
- W2019790163 cites W2056480485 @default.
- W2019790163 cites W2056550647 @default.
- W2019790163 cites W2056781637 @default.
- W2019790163 cites W2058346978 @default.
- W2019790163 cites W2059594509 @default.
- W2019790163 cites W2060990349 @default.
- W2019790163 cites W2083422545 @default.
- W2019790163 cites W2090951806 @default.
- W2019790163 cites W2094051937 @default.
- W2019790163 cites W2096796564 @default.
- W2019790163 cites W2098812571 @default.
- W2019790163 cites W2107794186 @default.
- W2019790163 cites W2109998847 @default.
- W2019790163 cites W2114217399 @default.
- W2019790163 cites W2136534232 @default.
- W2019790163 cites W2142157138 @default.
- W2019790163 cites W2142682936 @default.
- W2019790163 cites W2149732532 @default.
- W2019790163 cites W2150018728 @default.
- W2019790163 cites W2155488587 @default.
- W2019790163 cites W2163550224 @default.
- W2019790163 cites W2165092208 @default.
- W2019790163 cites W2165512566 @default.
- W2019790163 cites W2169333620 @default.
- W2019790163 cites W2270552653 @default.
- W2019790163 cites W4249640059 @default.
- W2019790163 cites W4251695548 @default.
- W2019790163 doi "https://doi.org/10.1016/s0092-8674(00)80734-5" @default.
- W2019790163 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10219245" @default.
- W2019790163 hasPublicationYear "1999" @default.
- W2019790163 type Work @default.
- W2019790163 sameAs 2019790163 @default.
- W2019790163 citedByCount "354" @default.
- W2019790163 countsByYear W20197901632012 @default.
- W2019790163 countsByYear W20197901632013 @default.
- W2019790163 countsByYear W20197901632014 @default.
- W2019790163 countsByYear W20197901632015 @default.
- W2019790163 countsByYear W20197901632016 @default.
- W2019790163 countsByYear W20197901632017 @default.
- W2019790163 countsByYear W20197901632018 @default.
- W2019790163 countsByYear W20197901632019 @default.
- W2019790163 countsByYear W20197901632020 @default.
- W2019790163 countsByYear W20197901632021 @default.
- W2019790163 countsByYear W20197901632022 @default.
- W2019790163 countsByYear W20197901632023 @default.
- W2019790163 crossrefType "journal-article" @default.
- W2019790163 hasAuthorship W2019790163A5011792309 @default.
- W2019790163 hasAuthorship W2019790163A5028945409 @default.
- W2019790163 hasAuthorship W2019790163A5033692642 @default.
- W2019790163 hasAuthorship W2019790163A5057228307 @default.
- W2019790163 hasAuthorship W2019790163A5057386104 @default.
- W2019790163 hasAuthorship W2019790163A5066867755 @default.
- W2019790163 hasAuthorship W2019790163A5080063862 @default.
- W2019790163 hasBestOaLocation W20197901631 @default.
- W2019790163 hasConcept C104317684 @default.
- W2019790163 hasConcept C119056186 @default.
- W2019790163 hasConcept C153911025 @default.
- W2019790163 hasConcept C177336024 @default.
- W2019790163 hasConcept C183873130 @default.
- W2019790163 hasConcept C184604658 @default.
- W2019790163 hasConcept C207812311 @default.
- W2019790163 hasConcept C2780723820 @default.
- W2019790163 hasConcept C54355233 @default.
- W2019790163 hasConcept C83640560 @default.
- W2019790163 hasConcept C86803240 @default.
- W2019790163 hasConcept C90132467 @default.