FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019791978> ?p ?o ?g. }

• W2019791978 endingPage "9601" @default.
• W2019791978 startingPage "9592" @default.
• W2019791978 abstract "Alterations in GABA A receptor (GABA A R) expression and function, similar to those we described previously during pregnancy in the mouse dentate gyrus, may also occur in other brain regions. Here we show, using immunohistochemical techniques, a decreased δ subunit-containing GABA A R (δGABA A R) expression in the dentate gyrus, hippocampal CA1 region, thalamus, and striatum but not in the cerebral cortex. In the face of the highly elevated neurosteroid levels during pregnancy, which can act on δGABA A Rs, it may be beneficial to decrease the number of neurosteroid-sensitive receptors to maintain a steady-state level of neuronal excitability throughout pregnancy. Consistent with this hypothesis, the synaptic input/output (I/O) relationship in the dentate gyrus molecular layer in response to lateral perforant path stimulation was shifted to the left in hippocampal slices from pregnant compared with virgin mice. The addition of allopregnanolone, at levels comparable with those found during pregnancy (100 n m ), shifted the I/O curves in pregnant mice back to virgin levels. There was a decreased threshold to induce epileptiform local field potentials in slices from pregnant mice compared with virgin, but allopregnanolone reverted the threshold for inducing epileptiform activity to virgin levels. According to these data, neuronal excitability is increased in pregnant mice in the absence of allopregnanolone attributable to brain region-specific downregulation of δGABA A R expression. In brain regions, such as the cortex, that do not exhibit alterations in δGABA A R expression, there were no changes in the I/O relationship during pregnancy. Similarly, no changes in network excitability were detected in pregnant Gabrd −/− mice that lack δGABA A Rs, suggesting that changes in neuronal excitability during pregnancy are attributable to alterations in the expression of these receptors. Our findings indicate that alterations in δGABA A R expression during pregnancy result in brain region-specific increases in neuronal excitability that are restored by the high levels of allopregnanolone under normal conditions but under pathological conditions may result in neurological and psychiatric disorders associated with pregnancy and postpartum." @default.
• W2019791978 created "2016-06-24" @default.
• W2019791978 creator A5013705674 @default.
• W2019791978 creator A5017700541 @default.
• W2019791978 creator A5023589964 @default.
• W2019791978 creator A5086237037 @default.
• W2019791978 date "2009-07-29" @default.
• W2019791978 modified "2023-10-15" @default.
• W2019791978 title "Excitability Changes Related to GABA_AReceptor Plasticity during Pregnancy" @default.
• W2019791978 cites W1488634403 @default.
• W2019791978 cites W1569823139 @default.
• W2019791978 cites W1647312149 @default.
• W2019791978 cites W1973557149 @default.
• W2019791978 cites W1977373024 @default.
• W2019791978 cites W1980471589 @default.
• W2019791978 cites W1986368719 @default.
• W2019791978 cites W1994775090 @default.
• W2019791978 cites W1996622763 @default.
• W2019791978 cites W1998872047 @default.
• W2019791978 cites W2000951268 @default.
• W2019791978 cites W2004546008 @default.
• W2019791978 cites W2016321438 @default.
• W2019791978 cites W2019043248 @default.
• W2019791978 cites W2020420256 @default.
• W2019791978 cites W2032679733 @default.
• W2019791978 cites W2034812041 @default.
• W2019791978 cites W2052415888 @default.
• W2019791978 cites W2070510853 @default.
• W2019791978 cites W2072316582 @default.
• W2019791978 cites W2074113629 @default.
• W2019791978 cites W2085460027 @default.
• W2019791978 cites W2088143216 @default.
• W2019791978 cites W2090257440 @default.
• W2019791978 cites W2110887671 @default.
• W2019791978 cites W2141150770 @default.
• W2019791978 cites W2141861222 @default.
• W2019791978 cites W2144241466 @default.
• W2019791978 cites W4245117662 @default.
• W2019791978 cites W4293872195 @default.
• W2019791978 doi "https://doi.org/10.1523/jneurosci.2162-09.2009" @default.
• W2019791978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2875247" @default.
• W2019791978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19641122" @default.
• W2019791978 hasPublicationYear "2009" @default.
• W2019791978 type Work @default.
• W2019791978 sameAs 2019791978 @default.
• W2019791978 citedByCount "117" @default.
• W2019791978 countsByYear W20197919782012 @default.
• W2019791978 countsByYear W20197919782013 @default.
• W2019791978 countsByYear W20197919782014 @default.
• W2019791978 countsByYear W20197919782015 @default.
• W2019791978 countsByYear W20197919782016 @default.
• W2019791978 countsByYear W20197919782017 @default.
• W2019791978 countsByYear W20197919782018 @default.
• W2019791978 countsByYear W20197919782019 @default.
• W2019791978 countsByYear W20197919782020 @default.
• W2019791978 countsByYear W20197919782021 @default.
• W2019791978 countsByYear W20197919782022 @default.
• W2019791978 countsByYear W20197919782023 @default.
• W2019791978 crossrefType "journal-article" @default.
• W2019791978 hasAuthorship W2019791978A5013705674 @default.
• W2019791978 hasAuthorship W2019791978A5017700541 @default.
• W2019791978 hasAuthorship W2019791978A5023589964 @default.
• W2019791978 hasAuthorship W2019791978A5086237037 @default.
• W2019791978 hasBestOaLocation W20197919781 @default.
• W2019791978 hasConcept C126322002 @default.
• W2019791978 hasConcept C134018914 @default.
• W2019791978 hasConcept C148762608 @default.
• W2019791978 hasConcept C168258287 @default.
• W2019791978 hasConcept C169760540 @default.
• W2019791978 hasConcept C170493617 @default.
• W2019791978 hasConcept C185592680 @default.
• W2019791978 hasConcept C2776464000 @default.
• W2019791978 hasConcept C2778338918 @default.
• W2019791978 hasConcept C2779177108 @default.
• W2019791978 hasConcept C2779246727 @default.
• W2019791978 hasConcept C2781041448 @default.
• W2019791978 hasConcept C2781161787 @default.
• W2019791978 hasConcept C44796713 @default.
• W2019791978 hasConcept C71924100 @default.
• W2019791978 hasConcept C86803240 @default.
• W2019791978 hasConceptScore W2019791978C126322002 @default.
• W2019791978 hasConceptScore W2019791978C134018914 @default.
• W2019791978 hasConceptScore W2019791978C148762608 @default.
• W2019791978 hasConceptScore W2019791978C168258287 @default.
• W2019791978 hasConceptScore W2019791978C169760540 @default.
• W2019791978 hasConceptScore W2019791978C170493617 @default.
• W2019791978 hasConceptScore W2019791978C185592680 @default.
• W2019791978 hasConceptScore W2019791978C2776464000 @default.
• W2019791978 hasConceptScore W2019791978C2778338918 @default.
• W2019791978 hasConceptScore W2019791978C2779177108 @default.
• W2019791978 hasConceptScore W2019791978C2779246727 @default.
• W2019791978 hasConceptScore W2019791978C2781041448 @default.
• W2019791978 hasConceptScore W2019791978C2781161787 @default.
• W2019791978 hasConceptScore W2019791978C44796713 @default.
• W2019791978 hasConceptScore W2019791978C71924100 @default.
• W2019791978 hasConceptScore W2019791978C86803240 @default.
• W2019791978 hasIssue "30" @default.
• W2019791978 hasLocation W20197919781 @default.

• next