FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019795889> ?p ?o ?g. }

• W2019795889 endingPage "302" @default.
• W2019795889 startingPage "296" @default.
• W2019795889 abstract "Little is known about the biological properties of britanin, which is isolated from the flowers of Inula japonica (Inulae Flos). Based on our previous studies that Inulae Flos had anti-inflammation and anti-asthmatic activities, we tried to find the bioactive compounds from it. In this study, the anti-inflammatory effects of britanin on the inflammatory mediators as well as on nuclear factor (NF)-кB and mitogen-activated protein (MAP) kinase activation were evaluated in RAW 264.7 cells. Britanin inhibited the production of nitric oxide (NO) and prostaglandin E2 (PGE2) along with the expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. In addition, britanin reduced the release of pro-inflammatory cytokines, such as TNF-α, IL-1β, and IL-6. Furthermore, the phosphorylations of MAP kinases (p38 and JNK) in LPS-stimulated RAW 264.7 cells were suppressed by britanin. Moreover, britanin inhibited the NF-κB activation induced by LPS, which was associated with the abrogation of IκBα degradation and subsequent decreases in nuclear p65 levels. This study suggests that the anti-inflammatory activities of britanin might be attributed to the inhibition of iNOS and COX-2 and cytokine expression at least in part, through the attenuation of the phosphorylations of MAP kinases and NF-κB activation via IκBα degradation in macrophages. We conclude that britanin may have potential for the treatment of inflammatory diseases through the down-regulation of MAP kinases and NF-κB mediated activation of macrophages." @default.
• W2019795889 created "2016-06-24" @default.
• W2019795889 creator A5012424400 @default.
• W2019795889 creator A5015360946 @default.
• W2019795889 creator A5020740314 @default.
• W2019795889 creator A5023015473 @default.
• W2019795889 creator A5030819901 @default.
• W2019795889 creator A5047815027 @default.
• W2019795889 creator A5049887641 @default.
• W2019795889 creator A5054654340 @default.
• W2019795889 creator A5056306660 @default.
• W2019795889 creator A5065526777 @default.
• W2019795889 creator A5079374959 @default.
• W2019795889 date "2013-02-01" @default.
• W2019795889 modified "2023-10-06" @default.
• W2019795889 title "Britanin suppresses LPS-induced nitric oxide, PGE2 and cytokine production via NF-κB and MAPK inactivation in RAW 264.7 cells" @default.
• W2019795889 cites W1534551308 @default.
• W2019795889 cites W1966103571 @default.
• W2019795889 cites W1969224465 @default.
• W2019795889 cites W1976157094 @default.
• W2019795889 cites W1984993711 @default.
• W2019795889 cites W1999048147 @default.
• W2019795889 cites W2013138732 @default.
• W2019795889 cites W2020590566 @default.
• W2019795889 cites W2023213266 @default.
• W2019795889 cites W2025590326 @default.
• W2019795889 cites W2034831207 @default.
• W2019795889 cites W2035027020 @default.
• W2019795889 cites W2037445680 @default.
• W2019795889 cites W2042001022 @default.
• W2019795889 cites W2042407426 @default.
• W2019795889 cites W2046634887 @default.
• W2019795889 cites W2049742063 @default.
• W2019795889 cites W2051390158 @default.
• W2019795889 cites W2060630008 @default.
• W2019795889 cites W2066013116 @default.
• W2019795889 cites W2070205695 @default.
• W2019795889 cites W2071211356 @default.
• W2019795889 cites W2073993982 @default.
• W2019795889 cites W2085705777 @default.
• W2019795889 cites W2091037465 @default.
• W2019795889 cites W2118013936 @default.
• W2019795889 cites W2118682325 @default.
• W2019795889 cites W2120275497 @default.
• W2019795889 cites W2124455399 @default.
• W2019795889 cites W2138474332 @default.
• W2019795889 cites W2138992293 @default.
• W2019795889 cites W2141009029 @default.
• W2019795889 cites W2951307034 @default.
• W2019795889 cites W4239251959 @default.
• W2019795889 doi "https://doi.org/10.1016/j.intimp.2012.12.005" @default.
• W2019795889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23270759" @default.
• W2019795889 hasPublicationYear "2013" @default.
• W2019795889 type Work @default.
• W2019795889 sameAs 2019795889 @default.
• W2019795889 citedByCount "63" @default.
• W2019795889 countsByYear W20197958892013 @default.
• W2019795889 countsByYear W20197958892014 @default.
• W2019795889 countsByYear W20197958892015 @default.
• W2019795889 countsByYear W20197958892016 @default.
• W2019795889 countsByYear W20197958892017 @default.
• W2019795889 countsByYear W20197958892018 @default.
• W2019795889 countsByYear W20197958892019 @default.
• W2019795889 countsByYear W20197958892020 @default.
• W2019795889 countsByYear W20197958892021 @default.
• W2019795889 countsByYear W20197958892022 @default.
• W2019795889 countsByYear W20197958892023 @default.
• W2019795889 crossrefType "journal-article" @default.
• W2019795889 hasAuthorship W2019795889A5012424400 @default.
• W2019795889 hasAuthorship W2019795889A5015360946 @default.
• W2019795889 hasAuthorship W2019795889A5020740314 @default.
• W2019795889 hasAuthorship W2019795889A5023015473 @default.
• W2019795889 hasAuthorship W2019795889A5030819901 @default.
• W2019795889 hasAuthorship W2019795889A5047815027 @default.
• W2019795889 hasAuthorship W2019795889A5049887641 @default.
• W2019795889 hasAuthorship W2019795889A5054654340 @default.
• W2019795889 hasAuthorship W2019795889A5056306660 @default.
• W2019795889 hasAuthorship W2019795889A5065526777 @default.
• W2019795889 hasAuthorship W2019795889A5079374959 @default.
• W2019795889 hasConcept C104317684 @default.
• W2019795889 hasConcept C123298856 @default.
• W2019795889 hasConcept C132149769 @default.
• W2019795889 hasConcept C164027704 @default.
• W2019795889 hasConcept C178790620 @default.
• W2019795889 hasConcept C184235292 @default.
• W2019795889 hasConcept C185592680 @default.
• W2019795889 hasConcept C203014093 @default.
• W2019795889 hasConcept C2776914184 @default.
• W2019795889 hasConcept C2777622882 @default.
• W2019795889 hasConcept C2777730290 @default.
• W2019795889 hasConcept C2778690821 @default.
• W2019795889 hasConcept C2778754761 @default.
• W2019795889 hasConcept C2779730028 @default.
• W2019795889 hasConcept C51551487 @default.
• W2019795889 hasConcept C519581460 @default.
• W2019795889 hasConcept C55493867 @default.
• W2019795889 hasConcept C57074206 @default.
• W2019795889 hasConcept C62478195 @default.

• next