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• W2019801096 abstract "Objective Alpha-fetoprotein (AFP) is not a useful tumor marker for diagnosis of small hepatocellular carcinoma (HCC). There is over-expression of insulin-like growth factor (IGF)-II in HCC tissue. This study investigates the diagnostic application of IGF-II in small HCC. Material and methods Serum levels of IGF-II and AFP were determined in 41 patients with small cirrhotic HCC (≤3 cm), 41 sex- and age-matched patients with cirrhosis alone (LC), and 41 healthy adults. The optimal cut-off values for diagnosing HCC were determined with receiver operating characteristics (ROC) curve. Results Both IGF-II and AFP levels in HCC were higher than those in LC patients or controls (each p=0.0001). The IGF-II levels in LC patients were lower than those in controls (p=0.001). In HCC patients, multivariate analysis indicated that that both IGF-II (odds ratio, 4.54; 95% confidence interval, 2.15–9.55; p=0.0001) and AFP (odds ratio, 1.05; 95% confidence interval, 1.01–1.08; p=0.003) were found to be associated with an increased risk of presence of HCC. The optimal cut-off values of IGF-II (4.1 mg/g prealbumin) and AFP (50 ng/ml) were determined with ROC curves. The sensitivity, specificity, and diagnostic accuracy values for IGF-II were 63%, 90%, and 70%, respectively. Those for AFP were 44%, 95%, and 70%, respectively. Determination of both markers in parallel significantly increase the diagnostic accuracy (88%) and sensitivity (80%), with a high specificity (90%). Conclusions Serum IGF-II level can be used as an independent serologic marker or a complementary tumor marker to AFP for diagnosis of small HCC." @default.
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• W2019801096 date "2005-01-01" @default.
• W2019801096 modified "2023-10-04" @default.
• W2019801096 title "Serum insulin-like growth factor-II as a serologic marker of small hepatocellular carcinoma" @default.
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• W2019801096 doi "https://doi.org/10.1080/00365520410009311" @default.
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