FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019802635> ?p ?o ?g. }

• W2019802635 endingPage "1395" @default.
• W2019802635 startingPage "1388" @default.
• W2019802635 abstract "To determine whether opioid receptors (ORs) are involved in the delayed cardioprotection of ischemic preconditioning (IP), the effect of severe metabolic inhibition (MI) with a glucose-free buffer that contained sodium cyanide and 2-deoxy-D-glucose on the viability of isolated rat ventricular myocytes was first determined 20 hours after preconditioning with a sublethal metabolic inhibition (MIP) with a glucose-free buffer that contained 2-deoxy-D-glucose and lactate for 30 minutes in the presence of OR antagonists. With the use of trypan blue exclusion as an index of cell viability, severe MI killed >60% of the cells and the value increased significantly after MIP. In the presence of 5x10(-6) mol/L nor-binaltorphimine (nor-BNI), a selective kappa-OR antagonist, but not 5x10(-6) mol/L CTOP, a selective mu-OR antagonist, or 5x10(-6) mol/L naltrindole, a selective delta-OR antagonist, the cardioprotection of MIP was significantly attenuated. To verify the role of kappa-OR, we studied the effects of severe MI after pretreatment with the kappa-OR agonist U50,488H (UP) for 30 minutes. U50,488H at 3x10(-6) to 1x10(-4) mol/L increased cell viability concentration-dependently with an EC50 of 3.311x10(-6) mol/L. In the presence of 5x10(-6) nor-BNI, the cardioprotection of UP (3x10(-5) mol/L) was blocked. A time course study showed that UP-induced cardioprotection occurred in 2 windows: the first occurred approximately 1 hour later and the other occurred 16 to 20 hours later. Additional studies on cell contraction and intracellular Ca2+ ([Ca2+]i) revealed that both UP and MIP attenuated the inhibitory effects of severe MI on contractility and electrically induced [Ca2+]i transient in single ventricular myocytes. On blockade of protein kinase C, the delayed cardioprotections of UP and MIP were significantly attenuated. In conclusion, the results of the present study have provided evidence that kappa-OR mediates the cardioprotection of MIP, which may involve protein kinase C and [Ca2+]i." @default.
• W2019802635 created "2016-06-24" @default.
• W2019802635 creator A5042099352 @default.
• W2019802635 creator A5052685127 @default.
• W2019802635 creator A5089439923 @default.
• W2019802635 date "1999-06-25" @default.
• W2019802635 modified "2023-10-03" @default.
• W2019802635 title "Cardioprotection of Preconditioning by Metabolic Inhibition in the Rat Ventricular Myocyte" @default.
• W2019802635 cites W1487575673 @default.
• W2019802635 cites W1567601758 @default.
• W2019802635 cites W1971585967 @default.
• W2019802635 cites W1973783497 @default.
• W2019802635 cites W1983537876 @default.
• W2019802635 cites W1985059368 @default.
• W2019802635 cites W1985624231 @default.
• W2019802635 cites W1988359241 @default.
• W2019802635 cites W198847974 @default.
• W2019802635 cites W1992333528 @default.
• W2019802635 cites W1994171099 @default.
• W2019802635 cites W2003873419 @default.
• W2019802635 cites W2007398567 @default.
• W2019802635 cites W2010349791 @default.
• W2019802635 cites W2011366397 @default.
• W2019802635 cites W2019975211 @default.
• W2019802635 cites W2022229886 @default.
• W2019802635 cites W2024978043 @default.
• W2019802635 cites W2029300781 @default.
• W2019802635 cites W2040552456 @default.
• W2019802635 cites W2042777933 @default.
• W2019802635 cites W2043023167 @default.
• W2019802635 cites W2057824614 @default.
• W2019802635 cites W2067836358 @default.
• W2019802635 cites W2069518581 @default.
• W2019802635 cites W2083633281 @default.
• W2019802635 cites W2086286943 @default.
• W2019802635 cites W2093084635 @default.
• W2019802635 cites W2113162630 @default.
• W2019802635 cites W2164271771 @default.
• W2019802635 cites W2188628473 @default.
• W2019802635 cites W4211113649 @default.
• W2019802635 cites W4244194928 @default.
• W2019802635 cites W4250184701 @default.
• W2019802635 doi "https://doi.org/10.1161/01.res.84.12.1388" @default.
• W2019802635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10381890" @default.
• W2019802635 hasPublicationYear "1999" @default.
• W2019802635 type Work @default.
• W2019802635 sameAs 2019802635 @default.
• W2019802635 citedByCount "119" @default.
• W2019802635 countsByYear W20198026352012 @default.
• W2019802635 countsByYear W20198026352013 @default.
• W2019802635 countsByYear W20198026352014 @default.
• W2019802635 countsByYear W20198026352015 @default.
• W2019802635 countsByYear W20198026352016 @default.
• W2019802635 countsByYear W20198026352018 @default.
• W2019802635 countsByYear W20198026352023 @default.
• W2019802635 crossrefType "journal-article" @default.
• W2019802635 hasAuthorship W2019802635A5042099352 @default.
• W2019802635 hasAuthorship W2019802635A5052685127 @default.
• W2019802635 hasAuthorship W2019802635A5089439923 @default.
• W2019802635 hasBestOaLocation W20198026351 @default.
• W2019802635 hasConcept C126322002 @default.
• W2019802635 hasConcept C134018914 @default.
• W2019802635 hasConcept C170493617 @default.
• W2019802635 hasConcept C185592680 @default.
• W2019802635 hasConcept C190283241 @default.
• W2019802635 hasConcept C2776885963 @default.
• W2019802635 hasConcept C2777953665 @default.
• W2019802635 hasConcept C2778122271 @default.
• W2019802635 hasConcept C2778938600 @default.
• W2019802635 hasConcept C2779311647 @default.
• W2019802635 hasConcept C2779676291 @default.
• W2019802635 hasConcept C2780070996 @default.
• W2019802635 hasConcept C53227056 @default.
• W2019802635 hasConcept C541997718 @default.
• W2019802635 hasConcept C55493867 @default.
• W2019802635 hasConcept C71924100 @default.
• W2019802635 hasConcept C98274493 @default.
• W2019802635 hasConceptScore W2019802635C126322002 @default.
• W2019802635 hasConceptScore W2019802635C134018914 @default.
• W2019802635 hasConceptScore W2019802635C170493617 @default.
• W2019802635 hasConceptScore W2019802635C185592680 @default.
• W2019802635 hasConceptScore W2019802635C190283241 @default.
• W2019802635 hasConceptScore W2019802635C2776885963 @default.
• W2019802635 hasConceptScore W2019802635C2777953665 @default.
• W2019802635 hasConceptScore W2019802635C2778122271 @default.
• W2019802635 hasConceptScore W2019802635C2778938600 @default.
• W2019802635 hasConceptScore W2019802635C2779311647 @default.
• W2019802635 hasConceptScore W2019802635C2779676291 @default.
• W2019802635 hasConceptScore W2019802635C2780070996 @default.
• W2019802635 hasConceptScore W2019802635C53227056 @default.
• W2019802635 hasConceptScore W2019802635C541997718 @default.
• W2019802635 hasConceptScore W2019802635C55493867 @default.
• W2019802635 hasConceptScore W2019802635C71924100 @default.
• W2019802635 hasConceptScore W2019802635C98274493 @default.
• W2019802635 hasIssue "12" @default.
• W2019802635 hasLocation W20198026351 @default.
• W2019802635 hasLocation W20198026352 @default.
• W2019802635 hasOpenAccess W2019802635 @default.

• next