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- W2019803606 abstract "Antibody 21D8 catalyzes the solvent-sensitive decarboxylation of 3-carboxybenzisoxazoles. The crystal structure of chimeric Fab 21D8 with and without hapten at 1.61 Å and 2.10 Å, respectively, together with computational analysis, shows how a melange of polar and non-polar sites are exploited to achieve both substrate binding and acceleration of a reaction normally facilitated by purely aprotic dipolar media. The striking similarity of the decarboxylase and a series of unrelated esterase antibodies also highlights the chemical versatility of structurally conserved anion binding sites and the relatively subtle changes involved in fine-tuning the immunoglobulin pocket for recognition of different ligands and catalysis of different reactions." @default.
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- W2019803606 date "2000-10-01" @default.
- W2019803606 modified "2023-10-17" @default.
- W2019803606 title "Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8 1 1Edited by D. Rees" @default.
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- W2019803606 doi "https://doi.org/10.1006/jmbi.2000.4503" @default.
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