Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019804531> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2019804531 endingPage "426" @default.
- W2019804531 startingPage "421" @default.
- W2019804531 abstract "DINCH (diisononylcyclohexane-1,2-dicarboxylate) was introduced into the world market in 2002 as a non-aromatic plasticizer and phthalate substitute. We analyzed 300 urine samples (24 h voids) of the German Environmental Specimen Bank (ESB for Human tissues, ESB Hum) for specific DINCH metabolites by on-line HPLC–MS/MS with isotope dilution quantification. Urine samples of the ESB Hum were from the years 1999, 2003, 2006, 2009 and 2012, chosen to investigate the appearance and a possible trend of DINCH exposure since its market introduction. No DINCH metabolites were detected in the 1999 and 2003 samples. From 2006 on, the percentage of samples with DINCH metabolites above the LOQ increased significantly over the years (7% in 2006, 43% in 2009 and 98% in 2012). The cyclohexane-1,2-dicarboxylic acid-mono(hydroxy-isononyl) ester (OH-MINCH) was the predominant metabolite. Median (and 95th percentile) concentrations (in μg/l) increased from <LOQ (0.09) in 2006, to <LOQ (1.02) in 2009 to 0.39 (2.09) in 2012. All oxidized DINCH metabolites (OH-MINCH, cx-MINCH, oxo-MINCH) correlated strongly among each other (ρ > 0.75, p < 0.001). The median (95th percentile) DINCH intake in 2012 was calculated to be 0.14 (1.07) μg/kg body weight/day which is considerably below daily intakes currently deemed tolerable. DINCH is regarded to have a preferred toxicological profile over certain anti-androgenic phthalates. The continuation of DINCH measurements in the ESB Hum and other human biomonitoring studies like the German Environmental Survey (GerES) allows tracking the development of DINCH body burdens, the distribution of exposure levels and daily intakes, providing basic data for future toxicological assessment and further epidemiological studies." @default.
- W2019804531 created "2016-06-24" @default.
- W2019804531 creator A5016414214 @default.
- W2019804531 creator A5028210790 @default.
- W2019804531 creator A5056067006 @default.
- W2019804531 creator A5070626446 @default.
- W2019804531 creator A5079258290 @default.
- W2019804531 date "2014-03-01" @default.
- W2019804531 modified "2023-10-01" @default.
- W2019804531 title "Entering markets and bodies: Increasing levels of the novel plasticizer Hexamoll® DINCH® in 24h urine samples from the German Environmental Specimen Bank" @default.
- W2019804531 cites W1979232857 @default.
- W2019804531 cites W1989093319 @default.
- W2019804531 cites W2004929493 @default.
- W2019804531 cites W2015800331 @default.
- W2019804531 cites W2031467473 @default.
- W2019804531 cites W2035560219 @default.
- W2019804531 cites W2066683636 @default.
- W2019804531 cites W2068800606 @default.
- W2019804531 cites W2073276604 @default.
- W2019804531 cites W2074909265 @default.
- W2019804531 cites W2077775303 @default.
- W2019804531 cites W2162966347 @default.
- W2019804531 cites W2163417923 @default.
- W2019804531 cites W2171408177 @default.
- W2019804531 cites W2400270442 @default.
- W2019804531 doi "https://doi.org/10.1016/j.ijheh.2013.08.004" @default.
- W2019804531 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24029725" @default.
- W2019804531 hasPublicationYear "2014" @default.
- W2019804531 type Work @default.
- W2019804531 sameAs 2019804531 @default.
- W2019804531 citedByCount "90" @default.
- W2019804531 countsByYear W20198045312014 @default.
- W2019804531 countsByYear W20198045312015 @default.
- W2019804531 countsByYear W20198045312016 @default.
- W2019804531 countsByYear W20198045312017 @default.
- W2019804531 countsByYear W20198045312018 @default.
- W2019804531 countsByYear W20198045312019 @default.
- W2019804531 countsByYear W20198045312020 @default.
- W2019804531 countsByYear W20198045312021 @default.
- W2019804531 countsByYear W20198045312022 @default.
- W2019804531 countsByYear W20198045312023 @default.
- W2019804531 crossrefType "journal-article" @default.
- W2019804531 hasAuthorship W2019804531A5016414214 @default.
- W2019804531 hasAuthorship W2019804531A5028210790 @default.
- W2019804531 hasAuthorship W2019804531A5056067006 @default.
- W2019804531 hasAuthorship W2019804531A5070626446 @default.
- W2019804531 hasAuthorship W2019804531A5079258290 @default.
- W2019804531 hasConcept C107872376 @default.
- W2019804531 hasConcept C109051061 @default.
- W2019804531 hasConcept C142362112 @default.
- W2019804531 hasConcept C178790620 @default.
- W2019804531 hasConcept C185592680 @default.
- W2019804531 hasConcept C23161992 @default.
- W2019804531 hasConcept C2777477808 @default.
- W2019804531 hasConcept C2780026642 @default.
- W2019804531 hasConcept C2781005124 @default.
- W2019804531 hasConcept C31903555 @default.
- W2019804531 hasConcept C52119013 @default.
- W2019804531 hasConcept C554144382 @default.
- W2019804531 hasConcept C55493867 @default.
- W2019804531 hasConceptScore W2019804531C107872376 @default.
- W2019804531 hasConceptScore W2019804531C109051061 @default.
- W2019804531 hasConceptScore W2019804531C142362112 @default.
- W2019804531 hasConceptScore W2019804531C178790620 @default.
- W2019804531 hasConceptScore W2019804531C185592680 @default.
- W2019804531 hasConceptScore W2019804531C23161992 @default.
- W2019804531 hasConceptScore W2019804531C2777477808 @default.
- W2019804531 hasConceptScore W2019804531C2780026642 @default.
- W2019804531 hasConceptScore W2019804531C2781005124 @default.
- W2019804531 hasConceptScore W2019804531C31903555 @default.
- W2019804531 hasConceptScore W2019804531C52119013 @default.
- W2019804531 hasConceptScore W2019804531C554144382 @default.
- W2019804531 hasConceptScore W2019804531C55493867 @default.
- W2019804531 hasIssue "2-3" @default.
- W2019804531 hasLocation W20198045311 @default.
- W2019804531 hasLocation W20198045312 @default.
- W2019804531 hasOpenAccess W2019804531 @default.
- W2019804531 hasPrimaryLocation W20198045311 @default.
- W2019804531 hasRelatedWork W1971820910 @default.
- W2019804531 hasRelatedWork W2018702281 @default.
- W2019804531 hasRelatedWork W2027270348 @default.
- W2019804531 hasRelatedWork W2041748192 @default.
- W2019804531 hasRelatedWork W2055722759 @default.
- W2019804531 hasRelatedWork W2090043726 @default.
- W2019804531 hasRelatedWork W2500547273 @default.
- W2019804531 hasRelatedWork W2777341500 @default.
- W2019804531 hasRelatedWork W3016322244 @default.
- W2019804531 hasRelatedWork W3081260119 @default.
- W2019804531 hasVolume "217" @default.
- W2019804531 isParatext "false" @default.
- W2019804531 isRetracted "false" @default.
- W2019804531 magId "2019804531" @default.
- W2019804531 workType "article" @default.