FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019817334> ?p ?o ?g. }

• W2019817334 endingPage "402" @default.
• W2019817334 startingPage "388" @default.
• W2019817334 abstract "Kalirin is a multifunctional protein identified by its interaction with peptidylglycine α-amidating monooxygenase, an enzyme essential for neuropeptide biosynthesis. Several forms of Kalirin exist, all containing spectrin-like repeats, a Dbl homology (DH) domain, and an adjacent pleckstrin homology (PH) domain; several different COOH-termini provide additional DH/PH domains and a putative protein kinase. Kalirin binds Rac1 and affects cytoskeletal organization, neuropeptide secretion, and iNOS activity. By in situ hybridization, the highest levels of Kalirin mRNA were found in the cerebral cortex, hippocampal formation, and Purkinje cells, with high levels also in thalamus, caudate putamen, septal nucleus, nucleus accumbens, amygdala, and anterior olfactory nucleus. Low levels of Kalirin mRNA were detected in the paraventricular, supraoptic, and reticular thalamic nuclei and in the ventromedial hypothalamic nucleus. Brain areas with high levels of Kalirin mRNA showed strong Kalirin-like immunoreactivity. Pyramidal neurons with strongly staining soma and long dendrites were observed primarily in layer 5 of the cerebral cortex. In the hippocampus, a uniform distribution of neurons with fine dendritic staining was observed in the pyramidal cell layer, in the granule cell layer, and in the hilar cells of the dentate gyrus as well as in isolated interneurons. Cerebellar Purkinje neurons exhibited intense staining in the soma and in extensive dendritic arbors extending to the surface of the molecular layer. During embryonic development, Trio, the Drosophila orthologue of Kalirin, plays an essential role in axon guidance; localization of Kalirin to the somatodendritic region of adult neurons provides the basis for future studies of regulation and function. J. Comp. Neurol. 429:388–402, 2001. © 2000 Wiley-Liss, Inc." @default.
• W2019817334 created "2016-06-24" @default.
• W2019817334 creator A5011997610 @default.
• W2019817334 creator A5013747215 @default.
• W2019817334 creator A5015706491 @default.
• W2019817334 creator A5019440310 @default.
• W2019817334 date "2000-01-01" @default.
• W2019817334 modified "2023-10-16" @default.
• W2019817334 title "Expression of Kalirin, a neuronal GDP/GTP exchange factor of the Trio family, in the central nervous system of the adult rat" @default.
• W2019817334 cites W102608180 @default.
• W2019817334 cites W1525734429 @default.
• W2019817334 cites W1532490237 @default.
• W2019817334 cites W1780117238 @default.
• W2019817334 cites W1940310886 @default.
• W2019817334 cites W1966732663 @default.
• W2019817334 cites W1969611022 @default.
• W2019817334 cites W1969780780 @default.
• W2019817334 cites W1970911352 @default.
• W2019817334 cites W1973535514 @default.
• W2019817334 cites W1980117659 @default.
• W2019817334 cites W1980821707 @default.
• W2019817334 cites W1982228241 @default.
• W2019817334 cites W2000572114 @default.
• W2019817334 cites W2006143986 @default.
• W2019817334 cites W2007058877 @default.
• W2019817334 cites W2008776698 @default.
• W2019817334 cites W2014090388 @default.
• W2019817334 cites W2020108403 @default.
• W2019817334 cites W2021374902 @default.
• W2019817334 cites W2029240910 @default.
• W2019817334 cites W2033300413 @default.
• W2019817334 cites W2035203219 @default.
• W2019817334 cites W2037089067 @default.
• W2019817334 cites W2041845866 @default.
• W2019817334 cites W2048887608 @default.
• W2019817334 cites W2059124316 @default.
• W2019817334 cites W2066123272 @default.
• W2019817334 cites W2067541328 @default.
• W2019817334 cites W2067871786 @default.
• W2019817334 cites W2077706363 @default.
• W2019817334 cites W2090417724 @default.
• W2019817334 cites W2095502762 @default.
• W2019817334 cites W2096472685 @default.
• W2019817334 cites W2096791952 @default.
• W2019817334 cites W2102226249 @default.
• W2019817334 cites W2115549514 @default.
• W2019817334 cites W2130196728 @default.
• W2019817334 cites W2148646831 @default.
• W2019817334 cites W2151760871 @default.
• W2019817334 cites W2161767563 @default.
• W2019817334 cites W2165892338 @default.
• W2019817334 cites W2320259697 @default.
• W2019817334 cites W6484253 @default.
• W2019817334 doi "https://doi.org/10.1002/1096-9861(20010115)429:3<388::aid-cne3>3.0.co;2-i" @default.
• W2019817334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11116227" @default.
• W2019817334 hasPublicationYear "2000" @default.
• W2019817334 type Work @default.
• W2019817334 sameAs 2019817334 @default.
• W2019817334 citedByCount "57" @default.
• W2019817334 countsByYear W20198173342012 @default.
• W2019817334 countsByYear W20198173342013 @default.
• W2019817334 countsByYear W20198173342014 @default.
• W2019817334 countsByYear W20198173342015 @default.
• W2019817334 countsByYear W20198173342016 @default.
• W2019817334 countsByYear W20198173342017 @default.
• W2019817334 countsByYear W20198173342018 @default.
• W2019817334 countsByYear W20198173342019 @default.
• W2019817334 countsByYear W20198173342020 @default.
• W2019817334 countsByYear W20198173342021 @default.
• W2019817334 countsByYear W20198173342023 @default.
• W2019817334 crossrefType "journal-article" @default.
• W2019817334 hasAuthorship W2019817334A5011997610 @default.
• W2019817334 hasAuthorship W2019817334A5013747215 @default.
• W2019817334 hasAuthorship W2019817334A5015706491 @default.
• W2019817334 hasAuthorship W2019817334A5019440310 @default.
• W2019817334 hasConcept C185592680 @default.
• W2019817334 hasConcept C49658373 @default.
• W2019817334 hasConcept C62478195 @default.
• W2019817334 hasConcept C86803240 @default.
• W2019817334 hasConcept C95444343 @default.
• W2019817334 hasConceptScore W2019817334C185592680 @default.
• W2019817334 hasConceptScore W2019817334C49658373 @default.
• W2019817334 hasConceptScore W2019817334C62478195 @default.
• W2019817334 hasConceptScore W2019817334C86803240 @default.
• W2019817334 hasConceptScore W2019817334C95444343 @default.
• W2019817334 hasIssue "3" @default.
• W2019817334 hasLocation W20198173341 @default.
• W2019817334 hasOpenAccess W2019817334 @default.
• W2019817334 hasPrimaryLocation W20198173341 @default.
• W2019817334 hasRelatedWork W1970788474 @default.
• W2019817334 hasRelatedWork W1985953812 @default.
• W2019817334 hasRelatedWork W2017729700 @default.
• W2019817334 hasRelatedWork W2026279251 @default.
• W2019817334 hasRelatedWork W2041907420 @default.
• W2019817334 hasRelatedWork W2053644475 @default.
• W2019817334 hasRelatedWork W2062685108 @default.
• W2019817334 hasRelatedWork W2102487598 @default.
• W2019817334 hasRelatedWork W2108863061 @default.

• next